dc-107 and Sarcoma-180
dc-107 has been researched along with Sarcoma-180* in 2 studies
Other Studies
2 other study(ies) available for dc-107 and Sarcoma-180
| Article | Year |
|---|---|
Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin.
A novel series of C-8 ester derivatives of leinamycin are described. Condensation of N-substituted amino acids or carboxylic acids containing polyether moiety with leinamycin resulted in the C-8 ester derivatives with good antitumor activity in several experimental models. Among these derivatives, compound 4e, which has five ethylene glycol ether units in the C-8 acyl group, showed potent antitumor activity against human tumor xenograft. Combination with the modification of the dithiolanone moiety was applied to these C-8 ester derivatives and some of them also showed good antitumor activity. Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Esters; HeLa Cells; Humans; Lactams; Leukemia P388; Macrolides; Mice; Mice, Nude; Sarcoma 180; Structure-Activity Relationship; Thiazoles; Thiones | 2003 |
Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Inhibitory Concentration 50; Lactams; Macrolides; Pyrans; Sarcoma 180; Structure-Activity Relationship; Thiazoles; Thiones; Tumor Cells, Cultured | 1999 |