dc-107 and Leukemia-P388

dc-107 has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for dc-107 and Leukemia-P388

Article	Year
Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin. Bioorganic & medicinal chemistry letters, 2003, Feb-10, Volume: 13, Issue:3 A novel series of C-8 ester derivatives of leinamycin are described. Condensation of N-substituted amino acids or carboxylic acids containing polyether moiety with leinamycin resulted in the C-8 ester derivatives with good antitumor activity in several experimental models. Among these derivatives, compound 4e, which has five ethylene glycol ether units in the C-8 acyl group, showed potent antitumor activity against human tumor xenograft. Combination with the modification of the dithiolanone moiety was applied to these C-8 ester derivatives and some of them also showed good antitumor activity. Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Esters; HeLa Cells; Humans; Lactams; Leukemia P388; Macrolides; Mice; Mice, Nude; Sarcoma 180; Structure-Activity Relationship; Thiazoles; Thiones	2003

Article

Year

Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin.

Bioorganic & medicinal chemistry letters, 2003, Feb-10, Volume: 13, Issue:3

A novel series of C-8 ester derivatives of leinamycin are described. Condensation of N-substituted amino acids or carboxylic acids containing polyether moiety with leinamycin resulted in the C-8 ester derivatives with good antitumor activity in several experimental models. Among these derivatives, compound 4e, which has five ethylene glycol ether units in the C-8 acyl group, showed potent antitumor activity against human tumor xenograft. Combination with the modification of the dithiolanone moiety was applied to these C-8 ester derivatives and some of them also showed good antitumor activity.

Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Esters; HeLa Cells; Humans; Lactams; Leukemia P388; Macrolides; Mice; Mice, Nude; Sarcoma 180; Structure-Activity Relationship; Thiazoles; Thiones

2003