Page last updated: 2024-10-24

sensory perception of taste

Definition

Target type: biologicalprocess

The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. [GOC:ai]

Taste perception, also known as gustation, is a complex biological process that allows us to experience the flavors of food and drink. It begins with the detection of taste molecules, known as tastants, by specialized sensory receptors located on the tongue and palate. These receptors are organized into taste buds, which are small clusters of cells that are embedded in the epithelium of the tongue and palate.

There are five basic taste qualities: sweet, sour, salty, bitter, and umami. Each taste quality is detected by a different type of taste receptor. Sweet receptors are activated by sugars and other sweet-tasting molecules. Sour receptors are activated by acids. Salty receptors are activated by salts, particularly sodium chloride. Bitter receptors are activated by a wide range of compounds, including alkaloids and toxins. Umami receptors are activated by glutamate, an amino acid found in many savory foods.

When a tastant binds to a taste receptor, it triggers a cascade of intracellular signaling events that lead to the release of neurotransmitters. These neurotransmitters transmit the taste signal to sensory neurons that project to the brainstem. From the brainstem, the taste signal is relayed to the thalamus, and finally to the gustatory cortex in the cerebral cortex, where it is processed and interpreted as taste.

The sense of taste is influenced by many other factors, including smell, texture, and temperature. The olfactory system plays a major role in taste perception, as the aroma of food can enhance or diminish its taste. The trigeminal nerve, which carries sensory information from the face, is also involved in taste perception, as it transmits information about the texture and temperature of food.

Taste perception is essential for survival, as it allows us to identify nutritious food and avoid potentially harmful substances. It is also a crucial part of our experience of food, as it contributes to our enjoyment of eating. The sense of taste is highly individual, and people can vary significantly in their sensitivity to different tastes.'
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Proteins (5)

ProteinDefinitionTaxonomy
Inositol 1,4,5-trisphosphate receptor type 3An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573]Homo sapiens (human)
P2X purinoceptor 2A P2X purinoceptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBL9]Homo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 3An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573]Homo sapiens (human)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62873]Homo sapiens (human)
P2X purinoceptor 3A P2X purinoceptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56373]Homo sapiens (human)

Compounds (29)

CompoundDefinitionClassesRoles
pyridoxal phosphatepyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.

Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate
coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid : An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid: a novel antagonist that selectively blocks P2 purinoceptor receptors; a useful tool to study co-transmission in tissues when ATP and coexisting neurotransmitters act in concert
arenesulfonic acid;
azobenzenes;
methylpyridines;
monohydroxypyridine;
organic phosphate;
pyridinecarbaldehyde
purinergic receptor P2X antagonist
suraminsuramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
naphthalenesulfonic acid;
phenylureas;
secondary carboxamide
angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
adenosine diphosphateAdenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate
fundamental metabolite;
human metabolite
diadenosine tetraphosphateP(1),P(4)-bis(5'-adenosyl) tetraphosphate : A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P(1)- and P(4)-positions.diadenosyl tetraphosphateEscherichia coli metabolite;
mouse metabolite
ormetoprimormetoprim: proposed chemotherapeutic agent; minor descriptor (75-84); on-line & Index Medicus search PYRIMIDINES (75-84)dimethoxybenzene
fluorone blackfluorone Black: structure
aminoquinuride
galleingallein : A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.

gallein: do not confuse with gallin; structure
2-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye
fluorochrome;
G-protein-coupled receptor antagonist;
histological dye
5'-adenylyl (beta,gamma-methylene)diphosphonate5'-adenylyl (beta,gamma-methylene)diphosphonate: do not confuse with alpha,beta-methyleneadenosine 5'-triphosphatenucleoside triphosphate analogue
alpha,beta-methyleneadenosine 5'-triphosphatealpha,beta-methyleneadenosine 5'-triphosphate: do not confuse with beta,gamma-methylene ATP; RN given refers to parent cpdnucleoside triphosphate analogue
1-amino-9,10-dioxo-4-(3-sulfamoylanilino)anthracene-2-sulfonic acid1-amino-9,10-dioxo-4-(3-sulfamoylanilino)anthracene-2-sulfonic acid: inhibits PH domain leucine-rich repeat protein phosphatase; structure in first source
inositol 1,4,5-trisphosphateInositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.myo-inositol trisphosphatemouse metabolite
adenosine 5'-o-(3-thiotriphosphate)adenosine 5'-[gamma-thio]triphosphate : A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur.

adenosine 5'-O-(3-thiotriphosphate): RN given refers to cpd with unspecified locant for thio group; see also records for 1-thio & 2-thio-isomers
nucleoside triphosphate analogue
8-azidoadenosine 5'-triphosphate
6-thioinosine-5'-triphosphateorganic molecule
spinorphinspinorphin: heptapeptide which is a potent inhibitor of enkephalin-degrading enzymes from the spinal cord or brain; does not show inhibitory activity toward enkephalin-degrading enzymes from kidney or blood; member of the opioid hemorphin familyoligopeptide
mrs 2219MRS 2219: P2X1 receptor agonist; structure in first source
imd 0354N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide: a cardioprotective agent that inhibits IkappaB kinase beta (IKKbeta); structure in first sourcebenzamides
2-methylthio-atp2-methylthio-ATP: purinergic receptors agonist; relaxes mammalian gut preparations; structure given in first source
adp beta sadenosine 5'-O-(2-thiodiphosphate): partial agonist toward platelet aggregation; see also record for 1-thiodiphosphate cpd
nf023
bafilomycin a1bafilomycin A1 : The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.

bafilomycin A1: from Streptomyces griseus; structure given in first source
cyclic hemiketal;
macrolide antibiotic;
oxanes
apoptosis inducer;
autophagy inhibitor;
bacterial metabolite;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
ferroptosis inhibitor;
fungicide;
potassium ionophore;
toxin
a-317491A-317491: structure in first source
af 3535-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine: a P2X3 and P2X2/3 receptor antagonist; structure in first source
a 803467A 803467: an Nav1.8 sodium channel blocker; structure in first source
archazolid aarchazolid A: inhibits vacuolar-type ATPase; isolated from Archangium gephyra; structure in first source
archazolid barchazolid B: structure in first sourcemacrolide
af-219Gefapixant: a P2X3 receptor antagonist