callystatin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

callystatin A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5471086
CHEMBL ID	200899
CHEBI ID	80782
SCHEMBL ID	16072414
MeSH ID	M0380045

Synonyms (20)

Synonym
2h-pyran-2-one,9,11,13,15-pentamethyl-12-oxo-1,3,7,9-heptadecatetraenyl)-5,6-dihydro-
189883-16-7
(2r)-2-[(1e,3z,5r,7e,9e,11r,13s,14r,15s)-3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxo-heptadeca-1,3,7,9-tetraenyl]-2,3-dihydropyran-6-one
2h-pyran-2-one, 6-[(1e,3z,5r,7e,9e,11r,13s,14r,15s)-3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxo-1,3,7,9-heptadecatetraenyl]-5,6-dihydro-, (6r)-
callystatin a
nsc-708248
nsc708248
C16891
CHEMBL200899
chebi:80782 ,
(2r)-2-[(1e,3z,5r,7e,9e,11r,13s,14r,15s)-3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxoheptadeca-1,3,7,9-tetraenyl]-2,3-dihydropyran-6-one
2h-pyran-2-one, 6-((1e,3z,5r,7e,9e,11r,13s,14r,15s)-3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxo-1,3,7,9-heptadecatetraenyl)-5,6-dihydro-, (6r)-
unii-zlk7n2r2d6
zlk7n2r2d6 ,
SCHEMBL16072414
Q5023018
DTXSID501029737
(6r)-6-((1e,3z,5r,7e,9e,11r,13s,14r,15s)-3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxo-1,3,7,9-heptadecatetraen-1-yl)-5,6-dihydro-2h-pyran-2-one
2h-pyran-2-one, 6-(3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxo-1,3,7,9-heptadecatetraenyl)-5,6-dihydro-, (6r-(6r(1e,3z,5r,7e,9e,11r,13s,14r,15s)))-
2h-pyran-2-one, 6-((1e,3z,5r,7e,9e,11r,13s,14r,15s)-3-ethyl-14-hydroxy-5,9,11,13,15-pentamethyl-12-oxo-1,3,7,9-heptadecatetraen-1-yl)-5,6-dihydro-, (6r)-

Research Excerpts

Overview

Callystatin A is a prominent member of a class of natural products which display promising growth inhibition of cancer cells in their biological profile.

Excerpt	Reference	Relevance
"Callystatin A is a prominent member of a class of natural products which display promising growth inhibition of cancer cells in their biological profile. "	( The total synthesis of (-)-callystatin A. Burzlaff, A; Chary, KP; Kalesse, M; Kasper, C; Quitschalle, M; Scheper, T, 2003)	2.06

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
diterpenoid	Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID258229	Cytotoxicity against HCT116 human colon cancer cell line	2006	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 16, Issue:2	Leptostatin: a synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (85.71)	29.6817
2010's	3 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.30 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	5.76 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.30)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	2	1	amino-acid anion
carbonic acid Carbonic Acid: Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)	2.04	1	carbon oxoacid; chalcocarbonic acid	mouse metabolite
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	2	1	diatomic iodine	nutrient
thiazoles [no description available]	2.04	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
propadiene [no description available]	2	1	allenes
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.42	2	metal allergen; nickel group element atom; platinum group metal atom
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	7.04	1	titanium group element atom
zirconium Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.	2	1	titanium group element atom
alkenes [no description available]	3.28	6
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	2.01	1	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
leptomycin b [no description available]	7.93	4
valtrate valtrate: Baldrisedon contains 100mg extract of Radix Valerianae mexicanae which contains 50mg valepotriate	2.01	1	fatty acid ester
iridoids Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).	2.01	1
tin [no description available]	2.42	2	carbon group element atom; elemental tin; metal atom	micronutrient
ratjadone ratjadone: structure in first source	2.04	1
scytophycin c scytophycin C: structure in first source	2.01	1	diterpene lactone
apoptolidin apoptolidin: an apoptosis inducer in transformed cells from Nocardiopsis sp.; structure in first source	2.01	1
discodermolide discodermolide: a lactone-bearing polyhydroxylated alkatetraene from the marine sponge Discodermia dissoluta; microtubule-stabilizing agent like taxol	2	1
archazolid a archazolid A: inhibits vacuolar-type ATPase; isolated from Archangium gephyra; structure in first source	2.04	1
archazolid b archazolid B: structure in first source	2.04	1	macrolide
leptomycin a [no description available]	2.04	1

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