Compounds > ratjadone
Page last updated: 2024-12-11

ratjadone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ratjadone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6444320
MeSH IDM0391426

Synonyms (14)

Synonym
ratjadon
(2r)-2-[(1e,3z,5r,7e,9e,11r)-11-hydroxy-11-[(2s,4r,5s,6s)-4-hydroxy-5-methyl-6-[(e)-prop-1-enyl]oxan-2-yl]-3,5,7-trimethylundeca-1,3,7,9-tetraenyl]-2,3-dihydropyran-6-one
2h-pyran-2-one, 5,6-dihydro-6-((1e,3z,5r,7e,9e,11r)-11-hydroxy-3,5,7-trimethyl-11-((2s,4r,5s,6s)-tetrahydro-4-hydroxy-5-methyl-6-((1e)-1-propenyl)-2h-pyran-2-yl)-1,3,7,9-undecatetraenyl)-, (6r)-
163564-92-9
ratjadone c (native)
ratjadone a, synthetic
(r)-6-((1e,3z,5r,7e,9e,11r)-11-hydroxy-11-((2s,4r,5s,6s)-4-hydroxy-5-methyl-6-((e)-prop-1-en-1-yl)tetrahydro-2h-pyran-2-yl)-3,5,7-trimethylundeca-1,3,7,9-tetraen-1-yl)-5,6-dihydro-2h-pyran-2-one
2h-pyran-2-one, 5,6-dihydro-6-[(1e,3z,5r,7e,9e,11r)-11-hydroxy-3,5,7-trimethyl-11-[(2s,4r,5s,6s)-tetrahydro-4-hydroxy-5-methyl-6-(1e)-1-propen-1-yl-2h-pyran-2-yl]-1,3,7,9-undecatetraen-1-yl]-, (6r)-
CS-0081658
ratjadone
HY-123177
DTXSID901043876
AKOS040747353
PD128667

Research Excerpts

Overview

Ratjadone C is a natural compound that inhibits the nuclear export of proteins.

ExcerptReferenceRelevance
"Ratjadone C is a natural compound that inhibits the nuclear export of proteins."( Ratjadone C-mediated nuclear accumulation of HDAC4: implications on Runx2-induced osteoblast differentiation of C3H10T1/2 mesenchymal stem cells.
Deepak, V; Jiang, Q; Kang, L; Liu, R; Liu, W; Meng, L; Mu, P; Zeng, X; Zhang, Z, )		2.3

Actions

ExcerptReferenceRelevance
"Ratjadones are able to inhibit the formation of the nuclear export complex composed of the CRM1, RanGTP, and the cargo protein, as shown by two different in vitro assays."( Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.
Elnakady, YA; Gerth, K; Hauser, H; Höfle, G; Kjems, J; Köster, M; Lykke-Andersen, S; Sasse, F; Washausen, P, 2003)		2.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (83.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.82 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		7.0210amino-acid anion
carbonic acid
Carbonic Acid: Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)		2.0410carbon oxoacid;
chalcocarbonic acid		mouse metabolite
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		2.0210L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
thiazoles
[no description available]		2.04101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
alpha-aminopyridine
alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.		5.4720
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0410metal allergen;
nickel group element atom;
platinum group metal atom
transferrin
Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.		2.0210
alkenes
[no description available]		2.0410
leptomycin b
[no description available]		10.9540
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0210cysteiniumfundamental metabolite
callystatin a
callystatin A: structure in first source		2.0410diterpenoid
archazolid a
archazolid A: inhibits vacuolar-type ATPase; isolated from Archangium gephyra; structure in first source		2.0410
archazolid b
archazolid B: structure in first source		2.0410macrolide
ConditionIndicatedRelationship StrengthStudiesTrials
HIV Coinfection
[description not available]		02.110
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).		02.110
Kahler Disease
[description not available]		02.0510
Neoplasms, Bone Marrow
[description not available]		02.0510
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.		02.0510
Bone Marrow Neoplasms
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.		02.0510
Cancer of Ovary
[description not available]		06.8840
Cancer of Pancreas
[description not available]		06.8840
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		06.8840
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		06.8840