Page last updated: 2024-12-11
ratjadone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
ratjadone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6444320 |
| MeSH ID | M0391426 |
Synonyms (14)
| Synonym |
|---|
| ratjadon |
| (2r)-2-[(1e,3z,5r,7e,9e,11r)-11-hydroxy-11-[(2s,4r,5s,6s)-4-hydroxy-5-methyl-6-[(e)-prop-1-enyl]oxan-2-yl]-3,5,7-trimethylundeca-1,3,7,9-tetraenyl]-2,3-dihydropyran-6-one |
| 2h-pyran-2-one, 5,6-dihydro-6-((1e,3z,5r,7e,9e,11r)-11-hydroxy-3,5,7-trimethyl-11-((2s,4r,5s,6s)-tetrahydro-4-hydroxy-5-methyl-6-((1e)-1-propenyl)-2h-pyran-2-yl)-1,3,7,9-undecatetraenyl)-, (6r)- |
| 163564-92-9 |
| ratjadone c (native) |
| ratjadone a, synthetic |
| (r)-6-((1e,3z,5r,7e,9e,11r)-11-hydroxy-11-((2s,4r,5s,6s)-4-hydroxy-5-methyl-6-((e)-prop-1-en-1-yl)tetrahydro-2h-pyran-2-yl)-3,5,7-trimethylundeca-1,3,7,9-tetraen-1-yl)-5,6-dihydro-2h-pyran-2-one |
| 2h-pyran-2-one, 5,6-dihydro-6-[(1e,3z,5r,7e,9e,11r)-11-hydroxy-3,5,7-trimethyl-11-[(2s,4r,5s,6s)-tetrahydro-4-hydroxy-5-methyl-6-(1e)-1-propen-1-yl-2h-pyran-2-yl]-1,3,7,9-undecatetraen-1-yl]-, (6r)- |
| CS-0081658 |
| ratjadone |
| HY-123177 |
| DTXSID901043876 |
| AKOS040747353 |
| PD128667 |
Research Excerpts
Overview
Ratjadone C is a natural compound that inhibits the nuclear export of proteins.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ratjadone C is a natural compound that inhibits the nuclear export of proteins." | ( Ratjadone C-mediated nuclear accumulation of HDAC4: implications on Runx2-induced osteoblast differentiation of C3H10T1/2 mesenchymal stem cells. Deepak, V; Jiang, Q; Kang, L; Liu, R; Liu, W; Meng, L; Mu, P; Zeng, X; Zhang, Z, ) | 2.3 |
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ratjadones are able to inhibit the formation of the nuclear export complex composed of the CRM1, RanGTP, and the cargo protein, as shown by two different in vitro assays." | ( Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. Elnakady, YA; Gerth, K; Hauser, H; Höfle, G; Kjems, J; Köster, M; Lykke-Andersen, S; Sasse, F; Washausen, P, 2003) | 2.48 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (12)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 16.82
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (16.82) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (7.69%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (92.31%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||