Compounds > 3'-deoxycytidine
Page last updated: 2024-12-08

3'-deoxycytidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID145986
CHEMBL ID368341
SCHEMBL ID98549
MeSH IDM0451752

Synonyms (18)

Synonym
3'-deoxycytidine
4-amino-1-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
brn 0616742
cytidine, 3'-deoxy-
7057-33-2
CHEMBL368341
4-amino-1-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
AKOS015917945
BRD-K79353080-001-01-5
SCHEMBL98549
J-700358
ZHHOTKZTEUZTHX-SHYZEUOFSA-N
AC-32253
mfcd00079144
4-amino-1-((2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one
DTXSID80990793
1-(3-deoxypentofuranosyl)-4-imino-1,4-dihydropyrimidin-2-ol
F11003
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID43519Inhibit the replication of CCRF-CEM cell line in vitro.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID248115Inhibitory concentration against hepatitis C virus NS5B-mediated RNA synthesis in HBI10A cells2005Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID202613Effective dose to inhibit the replication of S180 cell line in vitro.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID246380Effective concentration against hepatitis C virus RNA replication in a subgenomic bicistronic replicon in HBI10A cells2005Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID98041Effective dose to inhibit the replication of L1210 cell line in vitro.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID152349Effective dose to inhibit the replication of P388 cell line in vitro.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID245967Cytotoxic concentration of compound in human HBI10A cells infected with hepatitis C virus in MTS assay2005Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID658631Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase2012Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.06 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytarabine
[no description available]		1.9710beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
cordycepin
[no description available]		2.01103'-deoxyribonucleoside;
adenosines		antimetabolite;
nucleoside antibiotic
deoxycytidine
[no description available]		7.4320pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
deoxyuridine
[no description available]		2.0110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.0210pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.01101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
2'-o-methylcytidine
[no description available]		3.5520methylcytidine
4'-azidocytidine
4'-azidocytidine: antiviral; structure in first source		3.1710N-glycosyl compound
2'-c-methyladenosine
2'-C-methyladenosine: antiviral		3.1710
boron
Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.		2.0410boron group element atom;
metalloid atom;
nonmetal atom		micronutrient
hcv 796
HCV 796: inhibits HCV RdRp; structure in first source		3.1710
deoxyguanosine
[no description available]		2.0110purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2'-o-methylguanosine
2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.		3.5520methylguanosinemetabolite
3-deoxyguanosine
3'-deoxyguanosine : A 3'-deoxyribonucleoside having guanine as the nucleobase.		3.82303'-deoxyribonucleoside;
guanosines		EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		01.9710
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9710
Sarcoma 180
An experimental sarcoma of mice.		01.9710
Abnormalities, Autosome
[description not available]		02.0210