3'-deoxycytidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	145986
CHEMBL ID	368341
SCHEMBL ID	98549
MeSH ID	M0451752

Synonyms (18)

Synonym
3'-deoxycytidine
4-amino-1-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
brn 0616742
cytidine, 3'-deoxy-
7057-33-2
CHEMBL368341
4-amino-1-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
AKOS015917945
BRD-K79353080-001-01-5
SCHEMBL98549
J-700358
ZHHOTKZTEUZTHX-SHYZEUOFSA-N
AC-32253
mfcd00079144
4-amino-1-((2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one
DTXSID80990793
1-(3-deoxypentofuranosyl)-4-imino-1,4-dihydropyrimidin-2-ol
F11003

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID43519	Inhibit the replication of CCRF-CEM cell line in vitro.	1991	Journal of medicinal chemistry, Feb, Volume: 34, Issue:2	Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID248115	Inhibitory concentration against hepatitis C virus NS5B-mediated RNA synthesis in HBI10A cells	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID202613	Effective dose to inhibit the replication of S180 cell line in vitro.	1991	Journal of medicinal chemistry, Feb, Volume: 34, Issue:2	Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID246380	Effective concentration against hepatitis C virus RNA replication in a subgenomic bicistronic replicon in HBI10A cells	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID98041	Effective dose to inhibit the replication of L1210 cell line in vitro.	1991	Journal of medicinal chemistry, Feb, Volume: 34, Issue:2	Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID152349	Effective dose to inhibit the replication of P388 cell line in vitro.	1991	Journal of medicinal chemistry, Feb, Volume: 34, Issue:2	Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
AID245967	Cytotoxic concentration of compound in human HBI10A cells infected with hepatitis C virus in MTS assay	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID658631	Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase	2012	Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10	Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	18.06 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.66 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (18.06)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cytarabine [no description available]	1.97	1	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
cordycepin [no description available]	2.01	1	3'-deoxyribonucleoside; adenosines	antimetabolite; nucleoside antibiotic
deoxycytidine [no description available]	7.43	2	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
deoxyuridine [no description available]	2.01	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
zalcitabine Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.	2.02	1	pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
ribavirin Rebetron: Rebetron is tradename	2.01	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
2'-o-methylcytidine [no description available]	3.55	2	methylcytidine
4'-azidocytidine 4'-azidocytidine: antiviral; structure in first source	3.17	1	N-glycosyl compound
2'-c-methyladenosine 2'-C-methyladenosine: antiviral	3.17	1
boron Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.	2.04	1	boron group element atom; metalloid atom; nonmetal atom	micronutrient
hcv 796 HCV 796: inhibits HCV RdRp; structure in first source	3.17	1
deoxyguanosine [no description available]	2.01	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
2'-o-methylguanosine 2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.	3.55	2	methylguanosine	metabolite
3-deoxyguanosine 3'-deoxyguanosine : A 3'-deoxyribonucleoside having guanine as the nucleobase.	3.82	3	3'-deoxyribonucleoside; guanosines	EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor

Condition	Relationship Strength	Studies
Leukemia L 1210 [description not available]	1.97	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.97	1
Sarcoma 180 An experimental sarcoma of mice.	1.97	1
Abnormalities, Autosome [description not available]	2.02	1

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