3'-deoxyguanosine : A 3'-deoxyribonucleoside having guanine as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 135440068 |
| CHEMBL ID | 73502 |
| CHEBI ID | 39874 |
| SCHEMBL ID | 98906 |
| MeSH ID | M0451753 |
| Synonym |
|---|
| CHEMBL73502 , |
| 3'-deoxyguanosine |
| 2-amino-9-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1h-purin-6-one |
| 9-(3-deoxy-beta-d-ribofuranosyl)guanine |
| 3dg , |
| DB03609 |
| 3-deoxyguanosine |
| bdbm50144937 |
| 2-amino-9-((2r,3r,5s)-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one |
| 3608-58-0 |
| 2-amino-9-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one |
| guanosine, 3'-deoxy- |
| SCHEMBL98906 |
| 2-amino-9-((2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1h-purin-6(9h)-one |
| AKOS024260269 |
| guanine, 9-(3-deoxy-.beta.-d-erythro-pentofuranosyl)- |
| AC-32252 |
| DS-7383 |
| 9-((2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-imino-2,3-dihydro-1h-purin-6(9h)-one |
| 2-amino-9-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-purin-6-one |
| 3'-deoxy-guanosine |
| 3'-dg |
| 2-amino-9-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6h-purin-6-one |
| CHEBI:39874 |
| E78150 |
| Q27453726 |
| 9-(3-deoxypentofuranosyl)-2-imino-3,9-dihydro-2h-purin-6-ol |
| DTXSID80957487 |
| PD017579 |
| Role | Description |
|---|---|
| EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor | A DNA polymerase inhibitor that interferes with the action of a RNA-directed RNA polymerase (EC 2.7.7.48). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| 3'-deoxyribonucleoside | |
| guanosines | Any purine ribonucleoside that is a derivative of guanosine. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| RNA-directed RNA polymerase | IC50 (µMol) | 0.6000 | 0.0190 | 2.5279 | 8.8000 | AID86858 | |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | EC50 (µMol) | 50.0000 | 0.0026 | 0.5334 | 1.2020 | AID86857 |
| RNA-directed RNA polymerase | EC50 (µMol) | 50.0000 | 0.0018 | 0.2348 | 2.8000 | AID86857 | |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID246380 | Effective concentration against hepatitis C virus RNA replication in a subgenomic bicistronic replicon in HBI10A cells | 2005 | Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4 | Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication. |
| AID248115 | Inhibitory concentration against hepatitis C virus NS5B-mediated RNA synthesis in HBI10A cells | 2005 | Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4 | Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication. |
| AID658631 | Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10 | Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations. |
| AID86858 | Inhibition HCV NS5B-mediated RNA synthesis | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9 | Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. |
| AID86857 | Inhibition HCV RNA replication | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9 | Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||