Page last updated: 2024-12-08

3'-deoxycytidine 5'-triphosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID153054
CHEMBL ID480328
SCHEMBL ID6715771
MeSH IDM0099586

Synonyms (18)

Synonym
bdbm50333128
3''-deoxy-cytidine-5''-triphosphate
((2s,4r,5r)-5-(4-amino-2-oxopyrimidin-1(2h)-yl)-4-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
3''-dctp
[[(2s,4r,5r)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
3'-dctp
3'-deoxycytidine-5'-triphosphate
3'-deoxy-cytidine-5'-triphosphate
CH1 ,
3'-deoxycytidine 5'-triphosphate
CHEMBL480328 ,
cytidine 5'-(tetrahydrogen triphosphate), 3'-deoxy-
3'-deoxycytidine triphosphate
SCHEMBL6715771
3'-deoxycytidine 5'-(tetrahydrogen triphosphate)
Q27458809
DTXSID70989196
1-[3-deoxy-5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-4-imino-1,4-dihydropyrimidin-2-ol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Model simulations of analog:dNTP molar ratios using IPERGAY dosing suggested that FTC significantly contributes to the protective effect of preexposure prophylaxis (PrEP)."( Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates.
Anderson, PL; Bushman, LR; Castillo-Mancilla, JR; Chen, X; Kiser, JJ; MaWhinney, S; Seifert, SM; Zheng, JH, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 1A2Homo sapiens (human)IC50 (µMol)500.00000.00011.774010.0000AID547088
Cytochrome P450 3A4Homo sapiens (human)IC50 (µMol)500.00000.00011.753610.0000AID547088
RNA-directed RNA polymerase IC50 (µMol)0.77000.01902.52798.8000AID340760
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (38)

Processvia Protein(s)Taxonomy
steroid catabolic processCytochrome P450 1A2Homo sapiens (human)
porphyrin-containing compound metabolic processCytochrome P450 1A2Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 1A2Homo sapiens (human)
cholesterol metabolic processCytochrome P450 1A2Homo sapiens (human)
estrogen metabolic processCytochrome P450 1A2Homo sapiens (human)
toxin biosynthetic processCytochrome P450 1A2Homo sapiens (human)
post-embryonic developmentCytochrome P450 1A2Homo sapiens (human)
alkaloid metabolic processCytochrome P450 1A2Homo sapiens (human)
regulation of gene expressionCytochrome P450 1A2Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 1A2Homo sapiens (human)
dibenzo-p-dioxin metabolic processCytochrome P450 1A2Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 1A2Homo sapiens (human)
lung developmentCytochrome P450 1A2Homo sapiens (human)
methylationCytochrome P450 1A2Homo sapiens (human)
monocarboxylic acid metabolic processCytochrome P450 1A2Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 1A2Homo sapiens (human)
retinol metabolic processCytochrome P450 1A2Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 1A2Homo sapiens (human)
cellular respirationCytochrome P450 1A2Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 1A2Homo sapiens (human)
hydrogen peroxide biosynthetic processCytochrome P450 1A2Homo sapiens (human)
oxidative demethylationCytochrome P450 1A2Homo sapiens (human)
cellular response to cadmium ionCytochrome P450 1A2Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 1A2Homo sapiens (human)
lipid hydroxylationCytochrome P450 3A4Homo sapiens (human)
lipid metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid catabolic processCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid metabolic processCytochrome P450 3A4Homo sapiens (human)
cholesterol metabolic processCytochrome P450 3A4Homo sapiens (human)
androgen metabolic processCytochrome P450 3A4Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A4Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A4Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 3A4Homo sapiens (human)
calcitriol biosynthetic process from calciolCytochrome P450 3A4Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D metabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D catabolic processCytochrome P450 3A4Homo sapiens (human)
retinol metabolic processCytochrome P450 3A4Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A4Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 3A4Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A4Homo sapiens (human)
oxidative demethylationCytochrome P450 3A4Homo sapiens (human)
RNA-templated transcriptionDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
DNA-templated transcription terminationDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
regulation of DNA-templated transcriptionDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
transcription by RNA polymerase IIDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
positive regulation of RNA splicingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (39)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 1A2Homo sapiens (human)
iron ion bindingCytochrome P450 1A2Homo sapiens (human)
protein bindingCytochrome P450 1A2Homo sapiens (human)
electron transfer activityCytochrome P450 1A2Homo sapiens (human)
oxidoreductase activityCytochrome P450 1A2Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 1A2Homo sapiens (human)
enzyme bindingCytochrome P450 1A2Homo sapiens (human)
heme bindingCytochrome P450 1A2Homo sapiens (human)
demethylase activityCytochrome P450 1A2Homo sapiens (human)
caffeine oxidase activityCytochrome P450 1A2Homo sapiens (human)
aromatase activityCytochrome P450 1A2Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 1A2Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 1A2Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityCytochrome P450 1A2Homo sapiens (human)
monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
steroid bindingCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 3A4Homo sapiens (human)
protein bindingCytochrome P450 3A4Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A4Homo sapiens (human)
oxygen bindingCytochrome P450 3A4Homo sapiens (human)
enzyme bindingCytochrome P450 3A4Homo sapiens (human)
heme bindingCytochrome P450 3A4Homo sapiens (human)
vitamin D3 25-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
caffeine oxidase activityCytochrome P450 3A4Homo sapiens (human)
quinine 3-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
aromatase activityCytochrome P450 3A4Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
protein bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
magnesium ion bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
DNA bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
RNA bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
DNA-directed 5'-3' RNA polymerase activityDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
RNA-dependent RNA polymerase activityDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
protein bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
zinc ion bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
hydrolase activityDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
kinase bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
ubiquitin protein ligase bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
microfibril bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
promoter-specific chromatin bindingDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
RNA polymerase II activityDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (10)

Processvia Protein(s)Taxonomy
endoplasmic reticulum membraneCytochrome P450 1A2Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1A2Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1A2Homo sapiens (human)
cytoplasmCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A4Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A4Homo sapiens (human)
nucleolusDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
Prp19 complexDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
nucleusDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
nucleoplasmDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
chromosomeDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
cytoplasmDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
RNA polymerase II, core complexDNA-directed RNA polymerase II subunit RPB1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID547087Inhibition of human RNA polymerase 2 assessed as synthesis of RNA products at 1 uM2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
AID547088Inhibition of human RNA polymerase 22010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
AID547086Inhibition of human RNA polymerase 2 assessed as synthesis of RNA products at 500 uM2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
AID340760Inhibition of HCV NS5B polymerase S282T mutant assessed as blocking of full length RNA product formation by single-nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase.
AID340761Ratio of IC50 for HCV NS5B polymerase S282T mutant to IC50 for HCV NS5B polymerase by single-nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase.
AID340759Inhibition of HCV NS5B polymerase assessed as blocking of full length RNA product formation by single-nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase.
AID340758Inhibition of HCV NS5B polymerase assessed as chain termination of RNA synthesis2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.12 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.12)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational1 (16.67%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]