3,4-(dichloro)-5-hydroxy-2(5h)-furanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,4-(dichloro)-5-hydroxy-2(5H)-furanone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	91487
CHEMBL ID	1173058
SCHEMBL ID	1010785
MeSH ID	M0184155

Synonyms (34)

Synonym
nsc179787
2(5h)-furanone,4-dichloro-5-hydroxy-
766-40-5
nsc-179787
CHEMBL1173058
STK802150
3,4-dichloro-5-hydroxyfuran-2(5h)-one
3,4-dichloro-2-hydroxy-2h-furan-5-one
AKOS000121238
3,4-dichloro-5-hydroxy-2(5h)-furanone
3,4-dichloro-5-hydroxy-5h-furan-2-one
LU34940000
niosh/lu3494000
2(5h)-furanone, 3,4-dichloro-5-hydroxy-
BBL011015
ccris 3407
einecs 212-166-3
nsc 179787
3,4-(dichloro)-5-hydroxy-2(5h)-furanone
AM804336
SCHEMBL1010785
mucochlorsaure
FT-0698947
mfcd00272415
mucochloric acid lactone
DTXSID20273936
BCP15691
CS-0037410
AS-31848
EN300-21576
A922870
SB61342
2(5h)-furanone, 3,4-dichloro-5-hydroxy-; crotonic acid, 2,3-dichloro-4,4-dihydroxy-, ?-lactone (7ci,8ci); 3,4-dichloro-5-hydroxy-2(5h)-furanone; 5-hydroxy-3,4-dichloro-2-(5h)-furanone; mucochloric acid lactone; nsc 179787
AKOS016843438

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (37)

Assay ID	Title	Year	Journal	Article
AID1394938	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M-phase at 10 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 6.3 to 7.2%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394933	Cell cycle arrest in human A549 cells assessed as accumulation at G1-phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 59.4%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394925	Cytotoxicity against human LoVo cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394935	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M-phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 6.5%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394930	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394953	Effect on Pro-caspase-3 protein expression in human A549 cells at 20 uM after 72 hrs by densitometric analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394932	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394923	Cytotoxicity against p53-/- human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394947	Induction of apoptosis in human A549 cells assessed as necrotic cells at 20 uM after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.6%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394936	Cell cycle arrest in human A549 cells assessed as accumulation at G1-phase at 10 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 75.2 to 76%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394926	Cytotoxicity against human Hep3B cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394922	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394919	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394945	Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 20 uM after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.4%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394937	Cell cycle arrest in human A549 cells assessed as accumulation at S-phase at 10 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 16.8 to 18.5%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394946	Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 20 uM after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.5%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394955	Induction of apoptosis in human A549 cells assessed as caspase-3 cleavage at 20 uM after 72 hrs by Western blot analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394957	Anticlonogenic activity against human A549 cells at 10 uM after 24 to 72 hrs by crystal violet staining based microscopic method	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394934	Cell cycle arrest in human A549 cells assessed as accumulation at S-phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 34.1%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID492425	Antimalarial activity against Plasmodium falciparum	2009	Bioorganic & medicinal chemistry, May-01, Volume: 17, Issue:9	Antimalarials from nature.
AID1394924	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394952	Effect on Bcl-x protein expression in human A549 cells at 20 uM after 72 hrs by densitometric analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394929	Cytotoxicity against human SJSA1 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394927	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394931	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394921	Selectivity index, ratio of IC50 for human BEAS2B cells to IC50 for human A549 cells	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394939	Upregulation of Cyclin-B1 protein expression in human A549 cells at 10 uM after 72 hrs by Western blot analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394941	Cell cycle arrest in human A549 cells assessed as accumulation at G1-phase at 20 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 61.5%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394949	Effect on Bad protein expression in human A549 cells at 20 uM after 72 hrs by densitometric analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394942	Cell cycle arrest in human A549 cells assessed as accumulation at S-phase at 20 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 31.9%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394944	Induction of apoptosis in human A549 cells assessed as live cells at 20 uM after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 98.5%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394950	Effect on Bax protein expression in human A549 cells at 20 uM after 72 hrs by densitometric analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394920	Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394928	Cytotoxicity against human U2OS cells assessed as reduction in cell viability after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394951	Effect on Bcl2 protein expression in human A549 cells at 20 uM after 72 hrs by densitometric analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394954	Effect on cleaved caspase-3 protein expression in human A549 cells at 20 uM after 72 hrs by densitometric analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
AID1394943	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M-phase at 20 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 6.7%)	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (38.46)	18.2507
2000's	5 (38.46)	29.6817
2010's	3 (23.08)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.76 (24.57)
Research Supply Index	2.64 (2.92)
Research Growth Index	4.40 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.76)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.69%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	2.01	1	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	3.14	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	3.14	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
n-vinyl-2-pyrrolidinone N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source	2.17	1	pyrrolidin-2-ones
galantamine Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.	3.14	1	benzazepine alkaloid fundamental parent; benzazepine alkaloid; organic heterotetracyclic compound; tertiary amino compound	antidote to curare poisoning; cholinergic drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant metabolite
plumbagin plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.	3.14	1	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite
cepharanthine cepharanthine: isoquinoline alkaloid from tubers of STEPHANIA; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. cepharanthine : A bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.	3.14	1	bisbenzylisoquinoline alkaloid; isoquinolines
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	1.99	1	dialdehyde	biomarker
helenalin helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.	3.14	1	cyclic ketone; gamma-lactone; organic heterotricyclic compound; secondary alcohol; sesquiterpene lactone	anti-inflammatory agent; antineoplastic agent; metabolite; plant metabolite
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.39	2	diatomic chlorine; gas molecular entity	bleaching agent
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: structure given in first source	3.08	5	butenolide
3-chloro-4-methyl-5-hydroxy-2(5h)-furanone 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone: structure in first source	2.7	3
tetrahydropalmatine [no description available]	3.14	1	an (S)-7,8,13,14-tetrahydroprotoberberine; berberine alkaloid; organic heterotetracyclic compound	adrenergic agent; dopaminergic antagonist; non-narcotic analgesic
lycorine lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.	3.14	1	indolizidine alkaloid	anticoronaviral agent; antimalarial; plant metabolite; protein synthesis inhibitor
pinostrobin [no description available]	3.14	1	monohydroxyflavanone; monomethoxyflavanone	antidote; plant metabolite
cryptolepine cryptolepine: fused indole-quinoline; structure in first source; from CRYPTOLEPIS sanguinolenta. cryptolepine : An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.	3.14	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound	anti-inflammatory agent; antimalarial; antineoplastic agent; cysteine protease inhibitor; plant metabolite
phomenone phomenone: structure	3.14	1	sesquiterpenoid
3-chloro-4-(chloromethyl)-5-hydroxy-2(5h)-furanone 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone: structure given in first source	2.92	4
erlotinib [no description available]	2.17	1	aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound	antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor
diisocyanoadociane diisocyanoadociane: RN given for (1R-(1alpha,2alpha,3abeta,5alpha,5aalpha,8alpha,8aalpha,10abeta,10balpha,10cbeta))-isomer; structure in first source	3.14	1
norcoralydine norcoralydine: neuromuscular blocking agent; RN given refers to (S)-isomer; structure	3.14	1	alkaloid
anisomycin Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.	3.14	1	monohydroxypyrrolidine; organonitrogen heterocyclic antibiotic	anticoronaviral agent; antimicrobial agent; antineoplastic agent; antiparasitic agent; bacterial metabolite; DNA synthesis inhibitor; protein synthesis inhibitor
lupeol [no description available]	3.14	1	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
dentatin dentatin: from Clausena excavata; structure in first source	3.14	1	coumarins	metabolite
hemanthamine [no description available]	3.14	1	alkaloid
racemosol racemosol: from Bauhinia malabarica Roxb; don't confuse with stemanthrene D from STEMONA that was sometimes called racemosol;	3.14	1
mucochloric acid [no description available]	1.98	1
diethyl maleate diethyl maleate : A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.	1.97	1	ethyl ester; maleate ester	glutathione depleting agent
catechin gallate catechin gallate: structure in first source. (+)-catechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-catechin.	3.14	1	flavans; gallate ester; polyphenol	metabolite
acacetin 5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.	3.14	1	dihydroxyflavone; monomethoxyflavone	anticonvulsant; plant metabolite
7,3'-dihydroxy-4'-methoxyisoflavone 7,3'-dihydroxy-4'-methoxyisoflavone: isolated from Astragali radix; structure in first source. calycosin : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position.	3.14	1	4'-methoxyisoflavones; 7-hydroxyisoflavones	antioxidant; metabolite
luteolin-7-glucoside luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	3.14	1	beta-D-glucoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antioxidant; plant metabolite
genistein [no description available]	3.14	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
budlein a budlein A: anti-inflammatory and analgesic sesquiterpene lactone from Viguiera robusta; structure in first source	3.14	1	sesquiterpenoid
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	3.14	1	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
cerulenin Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.	3.14	1	epoxide; monocarboxylic acid amide	antifungal agent; antiinfective agent; antilipemic drug; antimetabolite; antimicrobial agent; fatty acid synthesis inhibitor
clausarin clausarin: isolated from Enkleia siamensis; structure given in first source	3.14	1
iridal iridal: a plant triterpenoid; structure in first source	3.14	1
tazettine tazettine: from Amaryllidaceae	3.14	1	indole alkaloid fundamental parent; indole alkaloid
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	1.98	1	cysteinium	fundamental metabolite
4-hydroxylonchocarpin 4-hydroxylonchocarpin: structure in first source	3.14	1
dolastatin 10 dolastatin 10: from mollusk Dolabella auricularia; contains four amino acids, dolavaline, dolaisoleucine, dolaproine, valine and the primary amine dolaphenine; deo-dolastatin 10 is a new dolastatin 10 chiral derivative with MW of 784. dolastatin 10 : A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization.	3.14	1	1,3-thiazoles; tetrapeptide	animal metabolite; antineoplastic agent; apoptosis inducer; marine metabolite; microtubule-destabilising agent
mer nf5003f stachybotrydial: a pancreatic cholesterol esterase inhibitor; also inhibits fucosyltransferase and sialyltransferase; structure in first source	3.14	1
lepadin f lepadin F: cis-decahydroquinoline alkaloid from the Australian ascidian Aplidium tabascum; structure in first source	3.14	1
2',3,4,4'-tetrahydroxy-5-prenylchalcone [no description available]	3.14	1
3-epioleanolic acid [no description available]	3.14	1	triterpenoid	metabolite
dehydroabietinol dehydroabietinol: Isolated from Hyptis suaveolens; structure in first source	3.14	1	abietane diterpenoid; carbotricyclic compound
neo-kauluamine neo-kauluamine: manzamine alkaloid with potent activity against infectious diseases; structure in first source	3.14	1
eurycomanone [no description available]	3.14	1	cyclic ether; delta-lactone; enone; organic heteropentacyclic compound; pentol; quassinoid; secondary alcohol; secondary alpha-hydroxy ketone; tertiary alcohol	antimalarial; antineoplastic agent; metabolite
pycnidione pycnidione: potentiator of bleomycin; isolated from Gloeotinia; structure in first source	3.14	1

Condition	Relationship Strength	Studies
Carcinoma, Non-Small Cell Lung [description not available]	2.17	1
Cancer of Lung [description not available]	2.17	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.17	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.17	1
Bacterial Disease [description not available]	2.17	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.17	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.01	1
Cocarcinogenesis The combination of two or more different factors in the production of cancer.	2.01	1
Abnormalities, Autosome [description not available]	2.42	2

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