Compounds > 2,3,3',4,4',5-hexachlorobiphenyl
Page last updated: 2024-09-22

2,3,3',4,4',5-hexachlorobiphenyl

Cross-References

ID SourceID
PubMed CID38019
CHEMBL ID136496
CHEBI ID81522
SCHEMBL ID2279549
MeSH IDM0232156

Synonyms (26)

Synonym
2,3,3',4,4',5-hexachlorobiphenyl
1,1'-biphenyl, 2,3,3',4,4',5-hexachloro-
3,4,2',3',4',5'-hexachlorobiphenyl
2,3,4,5,3',4'-hexachlorobiphenyl
pcb 156
brn 2468827
cb 156
2,3,3',4,4',5-hexachloro-1,1'-biphenyl
38380-08-4
chebi:81522 ,
CHEMBL136496 ,
2,3,4,5,3',4'-hexachloro-biphenyl
1,2,3,4-tetrachloro-5-(3,4-dichlorophenyl)benzene
C18120
bdbm50408343
unii-4d6049m2oc
4d6049m2oc ,
AKOS015903523
DTXSID0052706 ,
SCHEMBL2279549
LCXMEXLGMKFLQO-UHFFFAOYSA-N
pcb no. 156 10 microg/ml in isooctane
pcb no. 156
2,3,3',4,4',5-hexachlorobiphenyl, 99%, vial of 100 mg, bz# 156, analytical standard
Q27155442
dtxcid9031301

Drug Classes (3)

ClassDescription
dichlorobenzeneAny member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
tetrachlorobenzeneAny member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
hexachlorobiphenylAny polychlorobiphenyl with molecular formula C12H4Cl6.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 1A1Rattus norvegicus (Norway rat)EC50 (µMol)7.09580.00152.205710.0000AID39064
Aryl hydrocarbon receptorHomo sapiens (human)EC50 (µMol)7.09580.00151.976910.0000AID39064
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
blood vessel developmentAryl hydrocarbon receptorHomo sapiens (human)
regulation of adaptive immune responseAryl hydrocarbon receptorHomo sapiens (human)
negative regulation of T cell mediated immune response to tumor cellAryl hydrocarbon receptorHomo sapiens (human)
regulation of DNA-templated transcriptionAryl hydrocarbon receptorHomo sapiens (human)
regulation of transcription by RNA polymerase IIAryl hydrocarbon receptorHomo sapiens (human)
xenobiotic metabolic processAryl hydrocarbon receptorHomo sapiens (human)
apoptotic processAryl hydrocarbon receptorHomo sapiens (human)
response to xenobiotic stimulusAryl hydrocarbon receptorHomo sapiens (human)
response to toxic substanceAryl hydrocarbon receptorHomo sapiens (human)
regulation of gene expressionAryl hydrocarbon receptorHomo sapiens (human)
cAMP-mediated signalingAryl hydrocarbon receptorHomo sapiens (human)
intracellular receptor signaling pathwayAryl hydrocarbon receptorHomo sapiens (human)
regulation of B cell proliferationAryl hydrocarbon receptorHomo sapiens (human)
circadian regulation of gene expressionAryl hydrocarbon receptorHomo sapiens (human)
negative regulation of DNA-templated transcriptionAryl hydrocarbon receptorHomo sapiens (human)
positive regulation of DNA-templated transcriptionAryl hydrocarbon receptorHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIAryl hydrocarbon receptorHomo sapiens (human)
negative regulation of inflammatory responseAryl hydrocarbon receptorHomo sapiens (human)
cellular response to molecule of bacterial originAryl hydrocarbon receptorHomo sapiens (human)
cellular response to cAMPAryl hydrocarbon receptorHomo sapiens (human)
cellular response to forskolinAryl hydrocarbon receptorHomo sapiens (human)
cellular response to 2,3,7,8-tetrachlorodibenzodioxineAryl hydrocarbon receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Processvia Protein(s)Taxonomy
nuclear receptor activityAryl hydrocarbon receptorHomo sapiens (human)
transcription cis-regulatory region bindingAryl hydrocarbon receptorHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificAryl hydrocarbon receptorHomo sapiens (human)
cis-regulatory region sequence-specific DNA bindingAryl hydrocarbon receptorHomo sapiens (human)
TFIID-class transcription factor complex bindingAryl hydrocarbon receptorHomo sapiens (human)
transcription coactivator bindingAryl hydrocarbon receptorHomo sapiens (human)
DNA bindingAryl hydrocarbon receptorHomo sapiens (human)
DNA-binding transcription factor activityAryl hydrocarbon receptorHomo sapiens (human)
nuclear receptor activityAryl hydrocarbon receptorHomo sapiens (human)
protein bindingAryl hydrocarbon receptorHomo sapiens (human)
TBP-class protein bindingAryl hydrocarbon receptorHomo sapiens (human)
protein homodimerization activityAryl hydrocarbon receptorHomo sapiens (human)
protein heterodimerization activityAryl hydrocarbon receptorHomo sapiens (human)
Hsp90 protein bindingAryl hydrocarbon receptorHomo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingAryl hydrocarbon receptorHomo sapiens (human)
E-box bindingAryl hydrocarbon receptorHomo sapiens (human)
sequence-specific double-stranded DNA bindingAryl hydrocarbon receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (10)

Processvia Protein(s)Taxonomy
nucleusAryl hydrocarbon receptorHomo sapiens (human)
nuclear aryl hydrocarbon receptor complexAryl hydrocarbon receptorHomo sapiens (human)
nucleusAryl hydrocarbon receptorHomo sapiens (human)
nucleoplasmAryl hydrocarbon receptorHomo sapiens (human)
cytoplasmAryl hydrocarbon receptorHomo sapiens (human)
cytosolAryl hydrocarbon receptorHomo sapiens (human)
chromatinAryl hydrocarbon receptorHomo sapiens (human)
transcription regulator complexAryl hydrocarbon receptorHomo sapiens (human)
protein-containing complexAryl hydrocarbon receptorHomo sapiens (human)
cytosolic aryl hydrocarbon receptor complexAryl hydrocarbon receptorHomo sapiens (human)
aryl hydrocarbon receptor complexAryl hydrocarbon receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID39064Affinity on cytosolic Aromatic hydrocarbon receptor (Ah)1997Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (33.33)18.2507
2000's0 (0.00)29.6817
2010's5 (33.33)24.3611
2020's5 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
choline[no description available]medium10cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
dibenzofuran[no description available]medium10dibenzofurans;
mancude organic heterotricyclic parent;
polycyclic heteroarene		xenobiotic
imidazole[no description available]medium10imidazole
bw 284 c 51[no description available]medium10
1-methylimidazole[no description available]medium10imidazoles
tacrine[no description available]medium10acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
pentamidine[no description available]medium10aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
physostigmine[no description available]medium10carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
neostigmine bromide[no description available]medium10bromide salt
edrophonium bromide[no description available]medium10
azomycin[no description available]medium10C-nitro compound;
imidazoles		antitubercular agent
2-methylimidazole[no description available]medium10
chlormequat[no description available]medium10quaternary ammonium ionplant growth retardant
3-hydroxyphenyltrimethylammonium[no description available]medium10
1-methyl-2-nitroimidazole[no description available]medium10
2,3,7,8-tetrachlorodibenzodioxine[no description available]medium10polychlorinated dibenzodioxine
2,4,2',4'-tetrachlorobiphenyl[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
butyrylcholine[no description available]medium10acylcholine
octachlorodibenzo-4-dioxin[no description available]medium10polychlorinated dibenzodioxine
butyrylthiocholine[no description available]medium10quaternary ammonium ion
2-chlorodibenzofuran[no description available]medium10
1,2,3,4-tetrachlorodibenzodioxin[no description available]medium10polychlorinated dibenzodioxine
pcb 118[no description available]medium40dichlorobenzene;
pentachlorobiphenyl;
trichlorobenzene
3,4,3',4'-tetrachlorobiphenyl[no description available]medium20dichlorobenzene;
tetrachlorobiphenyl
2,3,3',4,4'-pentachlorobiphenyl[no description available]medium20dichlorobenzene;
pentachlorobiphenyl;
trichlorobenzene
2,3,4,5-tetrachlorobiphenyl[no description available]medium10tetrachlorobenzene;
tetrachlorobiphenyl
1,2,7,8-tetrachlorodibenzo-p-dioxin[no description available]medium10
2,4,5,2',4',5'-hexachlorobiphenyl[no description available]medium30hexachlorobiphenyl
thiocholine[no description available]medium10
2,8-dichlorodibenzo-4-dioxin[no description available]medium10
1,2,3,4,7,8-hexachlorodibenzodioxin[no description available]medium10polychlorinated dibenzodioxine
1,2,4-trichlorodibenzo-1,4-dioxin[no description available]medium10
1,2,3,7,8-pentachlorodibenzo-p-dioxin[no description available]medium20polychlorinated dibenzodioxine
2,3,7,8-tetrabromodibenzo-4-dioxin[no description available]medium10dibenzodioxine;
organobromine compound
2,3,7,8-tetrachlorodibenzofuran[no description available]medium20polychlorinated dibenzofuran
2,3,4,7,8-pentachlorodibenzofuran[no description available]medium20polychlorinated dibenzofuran
1,2,3,7,8-pentachlorodibenzofuran[no description available]medium10polychlorinated dibenzofuran
1,2,3,4,7,8-hexachlorodibenzofuran[no description available]medium10polychlorinated dibenzofuran
2,3,4,4'5-pentachlorobiphenyl[no description available]medium10monochlorobenzenes;
pentachlorobiphenyl;
tetrachlorobenzene
1,3-di-(4-imidazolino-2-methoxyphenoxy)propane[no description available]medium10
3,4,5,3',4'-pentachlorobiphenyl[no description available]medium40pentachlorobiphenyl;
trichlorobenzene
propamidine[no description available]medium10aromatic ether;
guanidines;
polyether		antimicrobial agent;
antiseptic drug
norharman[no description available]medium10beta-carbolines;
mancude organic heterotricyclic parent		fungal metabolite;
marine metabolite
hexamidine[no description available]medium10aromatic ether;
guanidines;
polyether		antimicrobial agent;
antiseptic drug
2-ethylimidazole[no description available]medium10
2-phenylimidazole[no description available]medium10
2-aminoimidazole[no description available]medium10
hexyltrimethylammonium[no description available]medium10
trimethyl(4-oxopentyl)ammonium[no description available]medium10quaternary ammonium ion
2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one[no description available]medium10
beta-carboline-3-carboxylic acid ethyl ester[no description available]medium10beta-carbolines
beta-carboline-3-carboxylic acid methyl ester[no description available]medium10beta-carbolines
1,3-di(4-imidazolinophenoxyl)propane[no description available]medium10
3-ethoxy-beta-carboline[no description available]medium10
tert-butyl beta-carboline-3-carboxylate[no description available]medium10
butamidine[no description available]medium10
3-chlorodibenzofuran[no description available]medium10
1-(4-hydroxybenzyl)imidazole-2-thiol[no description available]medium10
3-propoxy-beta-carboline[no description available]medium10
harman[no description available]medium10harmala alkaloid;
indole alkaloid fundamental parent;
indole alkaloid		anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite
1-Ethyl-9H-pyrido[3,4-b]indole[no description available]medium10harmala alkaloid
sk&f 102698[no description available]medium10
benzofurans[no description available]medium30
pyruvic acid[no description available]medium102-oxo monocarboxylic acidcofactor;
fundamental metabolite
chlorine[no description available]medium10diatomic chlorine;
gas molecular entity		bleaching agent
2,2',3',4,4',5-hexachlorobiphenyl[no description available]medium10polychlorobiphenyl
pcb 180[no description available]medium20polychlorobiphenyl
hexachlorobenzene[no description available]medium10aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
dichlorodiphenyl dichloroethylene[no description available]medium10chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
retinol[no description available]medium10retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
diethylnitrosamine[no description available]medium10nitrosaminecarcinogenic agent;
hepatotoxic agent;
mutagen
2,4-dichlorophenoxyacetic acid[no description available]low00chlorophenoxyacetic acid;
dichlorobenzene		agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin
am 251[no description available]low00amidopiperidine;
carbohydrazide;
dichlorobenzene;
organoiodine compound;
pyrazoles		antidepressant;
antineoplastic agent;
apoptosis inducer;
CB1 receptor antagonist
apraclonidine[no description available]low00dichlorobenzene;
guanidines;
imidazolines		alpha-adrenergic agonist;
antiglaucoma drug;
beta-adrenergic agonist;
diagnostic agent;
ophthalmology drug
bithionol[no description available]low00aryl sulfide;
bridged diphenyl antifungal drug;
bridged diphenyl fungicide;
dichlorobenzene;
organochlorine pesticide;
polyphenol		antifungal agrochemical;
antiplatyhelmintic drug
clenbuterol[no description available]low00amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
dicamba[no description available]low00dichlorobenzene;
methoxybenzoic acid		agrochemical;
environmental contaminant;
herbicide;
synthetic auxin;
xenobiotic
dichlobanil[no description available]low00dichlorobenzene;
nitrile		agrochemical;
cellulose synthesis inhibitor;
environmental contaminant;
herbicide;
xenobiotic
diclofenac[no description available]low00amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
dichlorphenamide[no description available]low00dichlorobenzene;
sulfonamide		antiglaucoma drug;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
ophthalmology drug
diuron[no description available]low003-(3,4-substituted-phenyl)-1,1-dimethylurea;
dichlorobenzene		environmental contaminant;
mitochondrial respiratory-chain inhibitor;
photosystem-II inhibitor;
urea herbicide;
xenobiotic
econazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
ethacrynic acid[no description available]low00aromatic ether;
aromatic ketone;
dichlorobenzene;
monocarboxylic acid		EC 2.5.1.18 (glutathione transferase) inhibitor;
ion transport inhibitor;
loop diuretic
felodipine[no description available]low00dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester		anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent
fipronil[no description available]low00(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
primary amino compound;
pyrazoles;
sulfoxide
liquid crystal polymer[no description available]low00conazole fungicide;
dichlorobenzene;
organobromine compound;
oxolanes;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
irsogladine[no description available]low00dichlorobenzene
isoconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
ketoconazole[no description available]low00dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
lamotrigine[no description available]low001,2,4-triazines;
dichlorobenzene;
primary arylamine		anticonvulsant;
antidepressant;
antimanic drug;
calcium channel blocker;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
excitatory amino acid antagonist;
geroprotector;
non-narcotic analgesic;
xenobiotic
lorglumide[no description available]low00benzamides;
dicarboxylic acid monoamide;
dichlorobenzene;
glutamic acid derivative
miconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
clorgyline[no description available]low00aromatic ether;
dichlorobenzene;
terminal acetylenic compound;
tertiary amino compound		antidepressant;
EC 1.4.3.4 (monoamine oxidase) inhibitor
4-dichlorobenzene[no description available]low00dichlorobenzeneinsecticide
methazole[no description available]low00dichlorobenzene
propanil[no description available]low00anilide;
dichlorobenzene		herbicide
sulconazole[no description available]low00dichlorobenzene;
imidazoles;
monochlorobenzenes;
organic sulfide
tioconazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
thiophenes
triclosan[no description available]low00aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
2,6-dichlorobenzoic acid[no description available]low00chlorobenzoic acid;
dichlorobenzene		bacterial xenobiotic metabolite
2,5-dichlorobenzoic acid[no description available]low00chlorobenzoic acid;
dichlorobenzene
2,4-dichlorobenzoic acid[no description available]low00chlorobenzoic acid;
dichlorobenzene		bacterial metabolite
2-dichlorobenzene[no description available]low00dichlorobenzenehepatotoxic agent;
metabolite
2,4-dichlorotoluene[no description available]low00dichlorobenzene
dicloran[no description available]low00aromatic fungicide;
dichlorobenzene;
nitroaniline		antifungal agrochemical
triclocarban[no description available]low00dichlorobenzene;
monochlorobenzenes;
phenylureas		antimicrobial agent;
antiseptic drug;
disinfectant;
environmental contaminant;
xenobiotic
dichlorprop[no description available]low00aromatic ether;
dichlorobenzene;
monocarboxylic acid
linuron[no description available]low00dichlorobenzene;
phenylureas		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
chlorfenvinphos[no description available]low00dichlorobenzene;
organic phosphate;
organochlorine acaricide;
organochlorine insecticide;
organophosphate insecticide		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
1,3-dichlorobenzene[no description available]low00dichlorobenzene
2,6-dichloroindophenol[no description available]low00dichlorobenzene;
quinone imine
3,3',4',5-tetrachlorosalicylanilide[no description available]low00dichlorobenzene;
salicylanilides		drug allergen
dichlorobenzyl alcohol[no description available]low00benzyl alcohols;
dichlorobenzene		antiseptic drug
2,6-dichlorobenzamide[no description available]low00benzamides;
dichlorobenzene		herbicide;
marine xenobiotic metabolite
3,4-dichlorophenylurea[no description available]low00dichlorobenzene;
phenylureas		marine xenobiotic metabolite
chloroneb[no description available]low00aromatic fungicide;
dichlorobenzene;
dimethoxybenzene		antifungal agrochemical
dicloxacillin[no description available]low00dichlorobenzene;
penicillin		antibacterial drug
clonidine hydrochloride[no description available]low00dichlorobenzene
lofexidine[no description available]low00aromatic ether;
carboxamidine;
dichlorobenzene;
imidazoles		alpha-adrenergic agonist;
antihypertensive agent
leptophos[no description available]low00bromobenzenes;
dichlorobenzene;
organic phosphonate;
phosphonic ester
pronamide[no description available]low00benzamides;
dichlorobenzene;
terminal acetylenic compound		agrochemical;
herbicide
kc 400[no description available]low00dichlorobenzene;
tetrachlorobiphenyl
prothiophos[no description available]low00dichlorobenzene;
organic thiophosphate;
organosulfur compound		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
2,5-dichlorobiphenyl[no description available]low00dichlorobenzene;
dichlorobiphenyl
3,5-dichlorobiphenyl[no description available]low00dichlorobenzene;
dichlorobiphenyl
enilconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
2,5,2',5'-tetrachlorobiphenyl[no description available]low00dichlorobenzene;
tetrachlorobiphenyl
ticrynafen[no description available]low00aromatic ether;
aromatic ketone;
dichlorobenzene;
monocarboxylic acid;
thiophenes		antihypertensive agent;
hepatotoxic agent;
loop diuretic
2-(4-(2,4-dichlorophenoxy)phenoxy)propionic acid[no description available]low00aromatic ether;
dichlorobenzene;
diether;
monocarboxylic acid
lonidamine[no description available]low00dichlorobenzene;
indazoles;
monocarboxylic acid		antineoplastic agent;
antispermatogenic agent;
EC 2.7.1.1 (hexokinase) inhibitor;
geroprotector
vinclozolin[no description available]low00dicarboximide;
dichlorobenzene;
olefinic compound;
oxazolidinone
dichlorfop-methyl[no description available]low00aromatic ether;
dichlorobenzene;
diether;
methyl ester
muzolimine[no description available]low00dichlorobenzene
azaconazole[no description available]low00conazole fungicide;
cyclic ketal;
dichlorobenzene;
dioxolane;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
propiconazole[no description available]low00conazole fungicide;
cyclic ketal;
dichlorobenzene;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
butoconazole[no description available]low00aryl sulfide;
conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes
dichlozolinate[no description available]low00dicarboximide;
dichlorobenzene;
ethyl ester;
oxazolidinone
fenticonazole[no description available]low00aryl sulfide;
dichlorobenzene;
ether;
imidazoles
itraconazole[no description available]low00aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles		EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor
aripiprazole[no description available]low00aromatic ether;
delta-lactam;
dichlorobenzene;
N-alkylpiperazine;
N-arylpiperazine;
quinolone		drug metabolite;
H1-receptor antagonist;
second generation antipsychotic;
serotonergic agonist
tobanum[no description available]low00dichlorobenzene
sertaconazole[no description available]low001-benzothiophenes;
dichlorobenzene;
ether;
imidazoles
hexaconazole[no description available]low00dichlorobenzene;
tertiary alcohol;
triazoles		chelator
sertraline[no description available]low00dichlorobenzene;
secondary amino compound;
tetralins		antidepressant;
serotonin uptake inhibitor
aceclofenac[no description available]low00amino acid;
carboxylic ester;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
fluphenacur[no description available]low00aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organofluorine compound
guanoclor[no description available]low00dichlorobenzene
tridiphane[no description available]low00dichlorobenzene
tetraconazole[no description available]low00dichlorobenzene;
ether;
organofluorine compound;
triazoles
n-(2,4-dichloro-5-(4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1h-1,2,4-triazol-1-yl)phenyl)methanesulfonamide[no description available]low00dichlorobenzene;
organofluorine compound;
sulfonamide;
triazoles		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
fluquinconazole[no description available]low00conazole fungicide;
dichlorobenzene;
organofluorine compound;
quinazolines;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
tolclofos-methyl[no description available]low00dichlorobenzene;
organic thiophosphate		antifungal agrochemical
penconazole[no description available]low00dichlorobenzene;
triazoles
chlorfluazuron[no description available]low00benzoylurea insecticide;
dichlorobenzene;
organochlorine insecticide;
organofluorine insecticide
fenpiclonil[no description available]low00dichlorobenzene;
nitrile;
pyrroles		antifungal agrochemical
teflubenzuron[no description available]low00dichlorobenzene;
difluorobenzene;
N-acylurea		environmental contaminant;
insecticide;
xenobiotic
hexafluoron[no description available]low00aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organochlorine insecticide;
organofluorine insecticide
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol[no description available]low00dichlorobenzene;
hydroxybiphenyls
sr141716[no description available]low00amidopiperidine;
carbohydrazide;
dichlorobenzene;
monochlorobenzenes;
pyrazoles		anti-obesity agent;
appetite depressant;
CB1 receptor antagonist
4,4'-bis(methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl[no description available]low00biphenyls;
dichlorobenzene;
sulfone
4'-hydroxydiclofenac[no description available]low00dichlorobenzene;
monocarboxylic acid;
phenols;
secondary amino compound		allergen;
drug metabolite
zoxamide[no description available]low00alpha-chloroketone;
benzamides;
dichlorobenzene
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone[no description available]low00dichlorobenzene;
differentiation-inducing factor;
monomethoxybenzene;
resorcinols		eukaryotic metabolite;
signalling molecule
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone[no description available]low00dichlorobenzene;
differentiation-inducing factor;
monomethoxybenzene;
resorcinols		eukaryotic metabolite;
signalling molecule
cgp 52432[no description available]low00dichlorobenzene
spirodiclofen[no description available]low00dichlorobenzene;
gamma-lactone;
organochlorine acaricide;
oxaspiro compound
n-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide[no description available]low00anilide fungicide;
aromatic amide;
dichlorobenzene;
monocarboxylic acid amide;
phenols		antifungal agrochemical;
EC 1.14.13.72 (methylsterol monooxygenase) inhibitor;
sterol biosynthesis inhibitor
2-(2,4-dichlorophenoxy)-N-(3-pyridinyl)acetamide[no description available]low00dichlorobenzene
3,5-dichlorotyrosine[no description available]low00chloroamino acid;
dichlorobenzene;
dihalogenated L-tyrosine;
non-proteinogenic L-alpha-amino acid
pd 173955[no description available]low00aryl sulfide;
dichlorobenzene;
methyl sulfide;
pyridopyrimidine		tyrosine kinase inhibitor
mln 4760[no description available]low00dichlorobenzene;
L-histidine derivative;
L-leucine derivative		anti-inflammatory agent;
EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor
olanexidine[no description available]low00dichlorobenzene
2-(2,4-dichlorophenoxy)-N-(2-furanylmethyl)acetamide[no description available]low00dichlorobenzene
2-[[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid butyl ester[no description available]low00dichlorobenzene
2-[[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid ethyl ester[no description available]low00dichlorobenzene
5,6-dichloro-1-ethyl-1,3-dihydro-2h-benzimidazol-2-one[no description available]low00dichlorobenzene
3-[(2,6-dichlorophenyl)methylthio]-4-methyl-5-thiophen-2-yl-1,2,4-triazole[no description available]low00dichlorobenzene
1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)ethanol[no description available]low00dichlorobenzene
N-[2-[5-[(2,4-dichlorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamic acid tert-butyl ester[no description available]low00dichlorobenzene
6-(2,4-dichlorophenyl)-1,5-diazabicyclo[3.1.0]hexane[no description available]low00dichlorobenzene
3-[(2,4-dichlorophenyl)methylthio]-1,2,4-thiadiazol-5-amine[no description available]low00dichlorobenzene
2-(2,4-dichlorophenyl)-3,5-dihydro-1H-pyrazolo[3,4-d]triazol-6-amine[no description available]low00dichlorobenzene
5-[(2,4-dichlorophenoxy)methyl]-N-[1-[(2-fluorophenyl)methyl]-3-pyrazolyl]-2-furancarboxamide[no description available]low00dichlorobenzene
1-[[2-(2,4-dichlorophenoxy)-1-oxoethyl]amino]-3-(4-fluorophenyl)thiourea[no description available]low00dichlorobenzene
[4-[[5-(2,4-dichlorophenyl)-3-isoxazolyl]-oxomethyl]-1-piperazinyl]-(2-furanyl)methanone[no description available]low00dichlorobenzene
5-(2,4-dichlorophenyl)-N-(4-methyl-2-thiazolyl)-2-furancarboxamide[no description available]low00dichlorobenzene
5-(2,5-dichlorophenyl)-N-(2-propyl-5-tetrazolyl)-2-furancarboxamide[no description available]low00dichlorobenzene
4-[2-[(3,4-dichlorophenyl)methylthio]-6-[(methylthio)methyl]-4-pyrimidinyl]morpholine[no description available]low00dichlorobenzene
3-[5-[(3,4-dichlorophenyl)methylthio]-4-ethyl-1,2,4-triazol-3-yl]-1-phenyl-4-pyridazinone[no description available]low00dichlorobenzene
5-[3-[(2,4-dichlorophenyl)methoxy]-2-thiophenyl]-1,2-dihydro-1,2,4-triazole-3-thione[no description available]low00dichlorobenzene
2-(2,4-dichlorophenyl)-5-[2-(methylthio)phenyl]-1,3,4-oxadiazole[no description available]low00dichlorobenzene
4-[2-[(2,4-dichlorophenyl)methylthio]-6-methyl-4-pyrimidinyl]morpholine[no description available]low00dichlorobenzene
4-(2,4-dichlorophenoxy)-N-(3-pyridinyl)butanamide[no description available]low00dichlorobenzene
4-(2,4-dichlorophenoxy)butanoic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester[no description available]low00dichlorobenzene
2-((3-(2,3-dichlorophenoxy)propyl)amino)ethanol[no description available]low00dichlorobenzene
2-(2,4-dichloro-6-methylphenoxy)-N-(2-furanylmethyl)acetamide[no description available]low00dichlorobenzene
4-[3-(2,4-dichlorophenyl)-5-isoxazolyl]-2-pyrimidinamine[no description available]low00dichlorobenzene
yoda 1[no description available]low00aromatic compound;
dichlorobenzene;
organic sulfide;
pyrazines;
thiadiazoles		glycine transporter 2 inhibitor;
piezo1 agonist
3-[[(2,4-dichlorophenyl)methylthio]methyl]-4-propan-2-yl-1H-1,2,4-triazole-5-thione[no description available]low00dichlorobenzene
N-[amino(1-pyrrolidinyl)methylidene]-3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamide[no description available]low00dichlorobenzene
N-[2-(2,4-dichlorophenyl)ethyl]-2-[[5-[1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]thio]acetamide[no description available]low00dichlorobenzene
nnd 502[no description available]low00dichlorobenzene
fenchlorazole-ethyl[no description available]low00dichlorobenzene
omoconazole[no description available]low00dichlorobenzene
u-50488[no description available]low00dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist
vx-745[no description available]low00aryl sulfide;
dichlorobenzene;
difluorobenzene;
pyrimidopyridazine		anti-inflammatory drug;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
5-hydroxydiclofenac[no description available]low00dichlorobenzene;
monocarboxylic acid;
phenols;
secondary amino compound		allergen;
drug metabolite
fipronil sulfone[no description available]low00(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
pyrazoles;
sulfone		marine xenobiotic metabolite
3-(2-chlorophenyl)-N-[5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]-5-methyl-4-isoxazolecarboxamide[no description available]low00dichlorobenzene
3-[2-(2,4-dichlorophenoxy)ethoxy]-6-methyl-2-nitropyridine[no description available]low00dichlorobenzene
5-[(2,4-dichlorophenoxy)methyl]-N-[3,5-dimethyl-1-[(2,3,4,5,6-pentafluorophenyl)methyl]-4-pyrazolyl]-2-furancarboxamide[no description available]low00dichlorobenzene
(3,5-dichloroanilino)thiourea[no description available]low00dichlorobenzene
N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide[no description available]low00D-leucine derivative;
dichlorobenzene;
furoic acid;
glycine derivative;
guanidines;
pyrazolylpiperidine
bosutinib[no description available]low00aminoquinoline;
aromatic ether;
dichlorobenzene;
N-methylpiperazine;
nitrile;
tertiary amino compound		antineoplastic agent;
tyrosine kinase inhibitor
oxiconazole[no description available]low00conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
oxime O-ether		antiinfective agent
guanabenz acetate[no description available]low00dichlorobenzenegeroprotector
guanabenz[no description available]low00dichlorobenzene
N-(3,4-dichlorophenyl)-6-(1-imidazolyl)-3-pyridazinamine[no description available]low00dichlorobenzene
diniconazole[no description available]low00dichlorobenzene;
olefinic compound;
secondary alcohol;
triazoles
chlorproguanil[no description available]low00dichlorobenzene
noviflumuron[no description available]low00aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
organofluorine compound
chir 99021[no description available]low00aminopyridine;
aminopyrimidine;
cyanopyridine;
diamine;
dichlorobenzene;
imidazoles;
secondary amino compound		EC 2.7.11.26 (tau-protein kinase) inhibitor
vilanterol[no description available]low00benzyl alcohols;
dichlorobenzene;
ether;
phenols;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent
gw 842166x[no description available]low00dichlorobenzene
pha 665752[no description available]low00dichlorobenzene;
enamide;
indolones;
N-acylpyrrolidine;
pyrrolecarboxamide;
secondary carboxamide;
sulfone;
tertiary carboxamide		antineoplastic agent;
c-Met tyrosine kinase inhibitor
tafamidis[no description available]low001,3-benzoxazoles;
dichlorobenzene;
monocarboxylic acid		central nervous system drug
fluopicolide[no description available]low00benzamide fungicide;
benzamides;
dichlorobenzene;
monochloropyridine;
organofluorine compound		antifungal agrochemical
gamendazole[no description available]low00alpha,beta-unsaturated monocarboxylic acid;
dichlorobenzene;
indazoles;
olefinic compound;
organofluorine compound		antispermatogenic agent;
eukaryotic translation elongation factor 1alpha 1 inhibitor;
Hsp90 inhibitor;
synthetic oral contraceptive
at 7519[no description available]low00dichlorobenzene;
piperidines;
pyrazoles;
secondary carboxamide		antineoplastic agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
s 1812[no description available]low00dichlorobenzene;
organochlorine insecticide;
organofluorine insecticide
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine[no description available]low00aminopyridine;
aromatic ether;
dichlorobenzene;
organofluorine compound;
pyrazolylpiperidine;
racemate		antineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
2-[(2,4-dichlorophenyl)methylthio]-1-methylimidazole[no description available]low00dichlorobenzene
avilamycin a[no description available]low00benzoate ester;
cyclic acetal;
dichlorobenzene;
oligosaccharide derivative;
ortho ester;
oxaspiro compound;
phenols;
tertiary alpha-hydroxy ketone		antimicrobial agent;
bacterial metabolite
gsk 1016790a[no description available]low001-benzothiophenes;
aromatic primary alcohol;
dichlorobenzene;
N-acylpiperazine;
sulfonamide;
tertiary carboxamide		TRPV4 agonist
poziotinib[no description available]low00acrylamides;
aromatic ether;
dichlorobenzene;
diether;
monofluorobenzenes;
N-acylpiperidine;
quinazolines;
secondary amino compound;
substituted aniline		antineoplastic agent;
apoptosis inducer;
epidermal growth factor receptor antagonist
ixazomib[no description available]low00benzamides;
boronic acids;
dichlorobenzene;
glycine derivative		antineoplastic agent;
apoptosis inducer;
drug metabolite;
orphan drug;
proteasome inhibitor
N-[(2S,3S)-2-[[(3,4-dichlorophenyl)methyl-methylamino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-2-(1-tetrazolyl)acetamide[no description available]low00dichlorobenzene
aripiprazole lauroxil[no description available]low00aromatic ether;
delta-lactam;
dichlorobenzene;
dodecanoate ester;
N-alkylpiperazine;
N-arylpiperazine;
quinolone		H1-receptor antagonist;
prodrug;
second generation antipsychotic;
serotonergic agonist
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea[no description available]low00aminopyrimidine;
dichlorobenzene;
N-alkylpiperazine;
N-arylpiperazine;
phenylureas		antineoplastic agent;
fibroblast growth factor receptor antagonist
chir 98014[no description available]low00aminopyrimidine;
C-nitro compound;
diaminopyridine;
dichlorobenzene;
imidazoles;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
hypoglycemic agent;
tau aggregation inhibitor;
Wnt signalling activator
LimKi 3[no description available]low001,3-thiazoles;
dichlorobenzene;
organofluorine compound;
pyrazoles;
secondary carboxamide		LIM kinase inhibitor
2-(4-chloroanilino)-5-[(2,3-dichlorophenyl)methyl]-4-thiazolone[no description available]low00dichlorobenzene
1,2,4,5-tetrachlorobenzene[no description available]low00tetrachlorobenzene
tetrachlorophthalic anhydride[no description available]low00cyclic dicarboxylic anhydride;
tetrachlorobenzene		allergen;
cross-linking reagent
tecnazene[no description available]low00aromatic fungicide;
C-nitro compound;
tetrachlorobenzene		antifungal agrochemical
1,2,3,4-tetrachlorobenzene[no description available]low00tetrachlorobenzene
1,2,3,5-tetrachlorobenzene[no description available]low00tetrachlorobenzene
3,4,5,6-tetrachlorocatechol[no description available]low00chlorocatechol;
tetrachlorobenzene
tetrachloroisophthalonitrile[no description available]low00aromatic fungicide;
dinitrile;
tetrachlorobenzene		antifungal agrochemical
4,5,6,7-tetrachlorophthalide[no description available]low00gamma-lactone;
organic heterobicyclic compound;
propan-1-ol;
tetrachlorobenzene		antifungal agrochemical;
melanin synthesis inhibitor
2,3,5,6-tetrachlorobiphenyl[no description available]low00tetrachlorobenzene;
tetrachlorobiphenyl
2,3,4,5,3',4',5'-heptachlorobiphenyl[no description available]low00heptachlorobiphenyl;
tetrachlorobenzene;
trichlorobenzene
2,3,5,6-tetrachlorohydroquinone[no description available]low00chlorohydroquinones;
tetrachlorobenzene
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl[no description available]low00biphenyls;
tetrachlorobenzene
3,4,5,3',4',5'-hexachlorobiphenyl[no description available]low00hexachlorobiphenyl;
trichlorobenzene
2,4,6,2',4',6'-hexachlorobiphenyl[no description available]low00hexachlorobiphenyl;
trichlorobenzene
2,3,5,2',3',5'-hexachlorobiphenyl[no description available]low00hexachlorobiphenyl;
trichlorobenzene
2,3,6,2',3',6'-hexachlorobiphenyl[no description available]low00hexachlorobiphenyl
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Liver Injury, Drug-Induced0low10
Body Weight0low10
Chemical and Drug Induced Liver Injury0low10
Chemically-Induced Liver Toxicity0low10
Drug-Induced Acute Liver Injury0low10
Drug-Induced Liver Disease0low10
Drug-Induced Liver Injury0low10
Fatty Liver, Nonalcoholic0low20
Hepatitis, Drug-Induced0low10
Hepatitis, Toxic0low10
Liver Injury, Drug-Induced0low10
Liver Injury, Drug-Induced, Acute0low10
NAFLD0low20
Non-alcoholic Fatty Liver Disease0low20
Nonalcoholic Fatty Liver Disease0low20
Nonalcoholic Steatohepatitis0low20
Pregnancy0low20
Toxic Hepatitis0low10
Weight Gain0low20

Research Highlights

Dosage (2)

ArticleYear
Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption.
Reproductive toxicology (Elmsford, N.Y.), Volume: 107		2022
Toxicity of PCB 156 in the rat liver: an ultrastructural and biochemical study.
Journal of submicroscopic cytology and pathology, Volume: 28, Issue: 1		1996
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Toxic potency of 2,3,3',4,4',5-hexachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat.
Toxicology and applied pharmacology, Volume: 126, Issue: 2		1994
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]