1,2,3,4,7,8-hexachlorodibenzofuran profile

## 1,2,3,4,7,8-Hexachlorodibenzofuran: A Potent Environmental Toxin

**1,2,3,4,7,8-hexachlorodibenzofuran (HxCDF)** is a highly toxic and persistent organic pollutant belonging to the **dioxin family**. It's a highly chlorinated derivative of dibenzofuran, a molecule consisting of two benzene rings connected by a furan ring.

**Why is it important for research?**

HxCDF and other dioxins are a critical focus of research for several reasons:

* **Toxicity:** HxCDF is incredibly toxic, classified as a **human carcinogen** by the International Agency for Research on Cancer (IARC). It exhibits various toxic effects on the immune, reproductive, and endocrine systems, leading to developmental and reproductive problems, immune suppression, and cancer.
* **Environmental persistence:** These compounds are **highly persistent** in the environment, meaning they break down very slowly and can accumulate in the food chain, posing a risk to wildlife and humans.
* **Bioaccumulation:** HxCDF can accumulate in fatty tissues, leading to increased concentrations in higher trophic levels, such as humans.
* **Sources:** HxCDF is primarily generated as a byproduct of industrial processes like **waste incineration, chemical production, and metal smelting**.
* **Health effects:** Research on HxCDF focuses on understanding its specific toxic mechanisms, developing methods for its detection and analysis, and identifying effective strategies for its prevention and remediation.

**Research focuses on:**

* **Understanding the mechanisms of HxCDF toxicity:** This involves investigating how it interacts with biological systems and causes cellular damage.
* **Developing analytical methods for HxCDF detection:** Accurate and sensitive analytical methods are essential for monitoring HxCDF levels in environmental samples and biological tissues.
* **Assessing the impact of HxCDF exposure on human health:** Research explores the relationship between HxCDF exposure and various health outcomes, such as cancer, developmental problems, and immune system dysfunction.
* **Developing strategies for HxCDF prevention and remediation:** Research focuses on minimizing HxCDF generation through better industrial practices, developing methods for its removal from contaminated sites, and exploring ways to reduce its accumulation in the environment.

**In summary, 1,2,3,4,7,8-hexachlorodibenzofuran is a highly toxic and persistent pollutant posing significant health risks to humans and the environment. Research on HxCDF aims to understand its toxicity, develop methods for its detection and control, and ultimately reduce its presence in the environment and protect public health.**

ID Source	ID
PubMed CID	51130
CHEMBL ID	342717
CHEBI ID	81509
SCHEMBL ID	2280219
MeSH ID	M0146366

Synonym
1,2,3,4,7,8-hexachlorodibenzofuran
dibenzofuran, 1,2,3,4,7,8-hexachloro-
1,2,3,4,7,8-hxcdf
70648-26-9
hcdf
chebi:81509 ,
CHEMBL342717 ,
1,2,3,4,7,8-hexachloro-dibenzofuran
C18107
pcdf 118
unii-bp4q20nzgy
bp4q20nzgy ,
bdbm50408291
55684-94-1
hexachlorobenzofuran, 1,2,3,4,7,8-
SCHEMBL2280219
LVYBAQIVPKCOEE-UHFFFAOYSA-N
DTXSID6029915
1,2,3,4,7,8-hexachlorobenzofuran
Q27155431
1,2,3,4,7,8-hexa-chlorodibenzofuran
1,2,3,4,7,8-hexachlorodibenzofuran 50 microg/ml in nonane

Excerpt	Reference	Relevance
"2,3,7,8-Tetrachlorodibenzo-p-dixoin 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) are highly toxic members of a class of environmental contaminants, the polychlorinated aromatic hydrocarbons (PCAH), which exhibit a similar and highly characteristic spectrum of toxic effects."	( Relative toxicity and tumor-promoting ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) in hairless mice. Birnbaum, LS; Elwell, MR; Harris, MW; Hébert, CD, 1990)	0.71

Excerpt	Relevance	Reference
" Female hairless mice (HRS/J hr/hr) were treated dermally with the initiator MNNG, then dosed twice weekly for 20 weeks with acetone, TCDD (2."	( Relative toxicity and tumor-promoting ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) in hairless mice. Birnbaum, LS; Elwell, MR; Harris, MW; Hébert, CD, 1990)	0.48

Class	Description
polychlorinated dibenzofuran	A member of the class of benzofurans that is benzofuran in which two or more of the hydrogens have reen replaced by chlorines.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cytochrome P450 1A1	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.2301	0.0015	2.2057	10.0000	AID39064
Aryl hydrocarbon receptor	Homo sapiens (human)	EC50 (µMol)	0.2301	0.0015	1.9769	10.0000	AID39064
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
blood vessel development	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of adaptive immune response	Aryl hydrocarbon receptor	Homo sapiens (human)
negative regulation of T cell mediated immune response to tumor cell	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of DNA-templated transcription	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Aryl hydrocarbon receptor	Homo sapiens (human)
xenobiotic metabolic process	Aryl hydrocarbon receptor	Homo sapiens (human)
apoptotic process	Aryl hydrocarbon receptor	Homo sapiens (human)
response to xenobiotic stimulus	Aryl hydrocarbon receptor	Homo sapiens (human)
response to toxic substance	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of gene expression	Aryl hydrocarbon receptor	Homo sapiens (human)
cAMP-mediated signaling	Aryl hydrocarbon receptor	Homo sapiens (human)
intracellular receptor signaling pathway	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of B cell proliferation	Aryl hydrocarbon receptor	Homo sapiens (human)
circadian regulation of gene expression	Aryl hydrocarbon receptor	Homo sapiens (human)
negative regulation of DNA-templated transcription	Aryl hydrocarbon receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Aryl hydrocarbon receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Aryl hydrocarbon receptor	Homo sapiens (human)
negative regulation of inflammatory response	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to molecule of bacterial origin	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to cAMP	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to forskolin	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine	Aryl hydrocarbon receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nuclear receptor activity	Aryl hydrocarbon receptor	Homo sapiens (human)
transcription cis-regulatory region binding	Aryl hydrocarbon receptor	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Aryl hydrocarbon receptor	Homo sapiens (human)
cis-regulatory region sequence-specific DNA binding	Aryl hydrocarbon receptor	Homo sapiens (human)
TFIID-class transcription factor complex binding	Aryl hydrocarbon receptor	Homo sapiens (human)
transcription coactivator binding	Aryl hydrocarbon receptor	Homo sapiens (human)
DNA binding	Aryl hydrocarbon receptor	Homo sapiens (human)
DNA-binding transcription factor activity	Aryl hydrocarbon receptor	Homo sapiens (human)
nuclear receptor activity	Aryl hydrocarbon receptor	Homo sapiens (human)
protein binding	Aryl hydrocarbon receptor	Homo sapiens (human)
TBP-class protein binding	Aryl hydrocarbon receptor	Homo sapiens (human)
protein homodimerization activity	Aryl hydrocarbon receptor	Homo sapiens (human)
protein heterodimerization activity	Aryl hydrocarbon receptor	Homo sapiens (human)
Hsp90 protein binding	Aryl hydrocarbon receptor	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Aryl hydrocarbon receptor	Homo sapiens (human)
E-box binding	Aryl hydrocarbon receptor	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Aryl hydrocarbon receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Aryl hydrocarbon receptor	Homo sapiens (human)
nuclear aryl hydrocarbon receptor complex	Aryl hydrocarbon receptor	Homo sapiens (human)
nucleus	Aryl hydrocarbon receptor	Homo sapiens (human)
nucleoplasm	Aryl hydrocarbon receptor	Homo sapiens (human)
cytoplasm	Aryl hydrocarbon receptor	Homo sapiens (human)
cytosol	Aryl hydrocarbon receptor	Homo sapiens (human)
chromatin	Aryl hydrocarbon receptor	Homo sapiens (human)
transcription regulator complex	Aryl hydrocarbon receptor	Homo sapiens (human)
protein-containing complex	Aryl hydrocarbon receptor	Homo sapiens (human)
cytosolic aryl hydrocarbon receptor complex	Aryl hydrocarbon receptor	Homo sapiens (human)
aryl hydrocarbon receptor complex	Aryl hydrocarbon receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID39064	Affinity on cytosolic Aromatic hydrocarbon receptor (Ah)	1997	Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26	Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (44.44)	18.7374
1990's	4 (44.44)	18.2507
2000's	1 (11.11)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (11.11%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
choline [no description available]	1.99	1	0	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
dibenzofuran Dibenzofurans: Compounds that include the structure of dibenzofuran.. dibenzofurans : Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof.. dibenzofuran : A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.	1.99	1	0	dibenzofurans; mancude organic heterotricyclic parent; polycyclic heteroarene	xenobiotic
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	1.99	1	0	imidazole
bw 284 c 51 [no description available]	1.99	1	0
1-methylimidazole 1-methyl-1H-imidazole : A 1H-imidazole having a methyl substituent at the N-1 position.	1.99	1	0	imidazoles
tacrine Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.	1.99	1	0	acridines; aromatic amine	EC 3.1.1.7 (acetylcholinesterase) inhibitor
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	1.99	1	0	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	6.96	1	0	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
physostigmine Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.	1.99	1	0	carbamate ester; indole alkaloid	antidote to curare poisoning; EC 3.1.1.8 (cholinesterase) inhibitor; miotic
neostigmine bromide neostigmine bromide : The bromide salt of neostigmine.	1.99	1	0	bromide salt
edrophonium bromide [no description available]	1.99	1	0
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	1.99	1	0	C-nitro compound; imidazoles	antitubercular agent
2-methylimidazole [no description available]	1.99	1	0
chlormequat Chlormequat: A plant growth regulator that is commonly used on ornamental plants.. chlormequat : A quaternary ammonium ion that is choline in which the hydroxy group has been replaced by a chlorine. Its salts (particularly the chloride salt, known as chlormequat chloride) are used as plant growth retardants.	1.99	1	0	quaternary ammonium ion	plant growth retardant
3-hydroxyphenyltrimethylammonium 3-hydroxyphenyltrimethylammonium: RN given refers to parent cpd; structure	1.99	1	0
1-methyl-2-nitroimidazole [no description available]	1.99	1	0
2,3,7,8-tetrachlorodibenzodioxine Tetrachlorodibenzodioxin: A mixture of isomers.	1.99	1	0	polychlorinated dibenzodioxine
2,4,2',4'-tetrachlorobiphenyl 2,4,2',4'-tetrachlorobiphenyl: structure. 2,2',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.	1.99	1	0	dichlorobenzene; tetrachlorobiphenyl
butyrylcholine butyrylcholine: RN given refers to parent cpd	1.99	1	0	acylcholine
octachlorodibenzo-4-dioxin octachlorodibenzo-4-dioxin: RN given refers to unlabeled parent cpd	1.99	1	0	polychlorinated dibenzodioxine
butyrylthiocholine Butyrylthiocholine: A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity.. butyrylthiocholine : A quaternary ammonium ion obtained by the formal condensation of the carboxy group of butyric acid with the thiol group of thiocholine. It is used as a reagent for determination of butyrylcholinesterase activity.	1.99	1	0	quaternary ammonium ion
2-chlorodibenzofuran 2-chlorodibenzofuran: structure	1.99	1	0
1,2,3,4-tetrachlorodibenzodioxin 1,2,3,4-tetrachlorodibenzodioxin: structure given in first source	1.99	1	0	polychlorinated dibenzodioxine
pcb 118 [no description available]	1.99	1	0	dichlorobenzene; pentachlorobiphenyl; trichlorobenzene
3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl: RN given refers to parent cpd. 3,3',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.	1.99	1	0	dichlorobenzene; tetrachlorobiphenyl
2,3,3',4,4'-pentachlorobiphenyl [no description available]	1.99	1	0	dichlorobenzene; pentachlorobiphenyl; trichlorobenzene
2,3,4,5-tetrachlorobiphenyl tetrachlorobiphenyl : Any polychlorobiphenyl with molecular formula C12H6Cl4.	1.99	1	0	tetrachlorobenzene; tetrachlorobiphenyl
1,2,7,8-tetrachlorodibenzo-p-dioxin 1,2,7,8-tetrachlorodibenzo-p-dioxin: structure in first source	1.99	1	0
2,4,5,2',4',5'-hexachlorobiphenyl [no description available]	1.99	1	0	hexachlorobiphenyl
thiocholine Thiocholine: A mercaptocholine used as a reagent for the determination of CHOLINESTERASES. It also serves as a highly selective nerve stain.	1.99	1	0
2,3,3',4,4',5-hexachlorobiphenyl [no description available]	1.99	1	0	dichlorobenzene; hexachlorobiphenyl; tetrachlorobenzene
2,8-dichlorodibenzo-4-dioxin 2,8-dichlorodibenzo-4-dioxin: metabolite for 2,3,7,8-TCDD	1.99	1	0
1,2,3,4,7,8-hexachlorodibenzodioxin 1,2,3,4,7,8-hexachlorodibenzodioxin: structure given in first source	1.99	1	0	polychlorinated dibenzodioxine
1,2,4-trichlorodibenzo-1,4-dioxin 1,2,4-trichlorodibenzo-1,4-dioxin: structure given in first source	1.99	1	0
1,2,3,7,8-pentachlorodibenzo-p-dioxin [no description available]	1.99	1	0	polychlorinated dibenzodioxine
2,3,7,8-tetrabromodibenzo-4-dioxin 2,3,7,8-tetrabromodibenzo-4-dioxin: structure given in first source. 2,3,7,8-tetrabromodibenzodioxine : An organobromine compound that is dibenzodioxine carrying four bromo substituents at positions 2, 3, 7 and 8.	1.99	1	0	dibenzodioxine; organobromine compound
2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran: toxic product which was generated in Italy due to an explosion in a plant manufacturing 2,4,5-trichlorophenol	1.99	1	0	polychlorinated dibenzofuran
2,3,4,7,8-pentachlorodibenzofuran 2,3,4,7,8-pentachlorodibenzofuran: structure given in first source	3.48	8	0	polychlorinated dibenzofuran
1,2,3,7,8-pentachlorodibenzofuran 1,2,3,7,8-pentachlorodibenzofuran: structure given in first source; RN given refers to parent cpd	3.79	2	1	polychlorinated dibenzofuran
2,3,4,4'5-pentachlorobiphenyl [no description available]	1.99	1	0	monochlorobenzenes; pentachlorobiphenyl; tetrachlorobenzene
1,3-di-(4-imidazolino-2-methoxyphenoxy)propane 1,3-di-(4-imidazolino-2-methoxyphenoxy)propane: structure given in first source	1.99	1	0
3,4,5,3',4'-pentachlorobiphenyl 3,3',4,4',5-pentachlorobiphenyl : A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.	1.99	1	0	pentachlorobiphenyl; trichlorobenzene
propamidine propamidine: structure given in first source. propamidine : A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.	1.99	1	0	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
norharman norharman: RN given refers to parent cpd. beta-carboline : The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.	1.99	1	0	beta-carbolines; mancude organic heterotricyclic parent	fungal metabolite; marine metabolite
hexamidine hexamidine : A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.	1.99	1	0	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
2-ethylimidazole [no description available]	1.99	1	0
2-phenylimidazole [no description available]	1.99	1	0
2-aminoimidazole 2-aminoimidazole: from catabolism of arginine	1.99	1	0
hexyltrimethylammonium hexyltrimethylammonium: RN given refers to parent cpd	1.99	1	0
trimethyl(4-oxopentyl)ammonium trimethyl(4-oxopentyl)ammonium: RN given refers to parent cpd; acetylcholine antag. N,N,N-trimethyl-N-(4-oxopentyl)ammonium : A quaternary ammonium ion in which the substituents on nitrogen are methyl (three) and 4-oxopentyl.	1.99	1	0	quaternary ammonium ion
2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one [no description available]	1.99	1	0
beta-carboline-3-carboxylic acid ethyl ester beta-carboline-3-carboxylic acid ethyl ester: isolated from brain tissue & urine; extremely potent displacer of diazepam from brain benzodiazepam receptors; structure in first source	1.99	1	0	beta-carbolines
beta-carboline-3-carboxylic acid methyl ester beta-carboline-3-carboxylic acid methyl ester: structure given in first source	1.99	1	0	beta-carbolines
1,3-di(4-imidazolinophenoxyl)propane 1,3-di(4-imidazolinophenoxyl)propane: structure given in first source	1.99	1	0
3-ethoxy-beta-carboline 3-ethoxy-beta-carboline: high affinity benzodiazepine receptor ligand with partial inverse agonist properties	1.99	1	0
tert-butyl beta-carboline-3-carboxylate tert-butyl beta-carboline-3-carboxylate: benzodiazepine receptor antagonist	1.99	1	0
butamidine butamidine: RN refers to HCl; structure in first source	1.99	1	0
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	4.86	8	1
3-chlorodibenzofuran 3-chlorodibenzofuran: structure given in first source	1.99	1	0
1-(4-hydroxybenzyl)imidazole-2-thiol 1-(4-hydroxybenzyl)imidazole-2-thiol: RN & structure given in first source; RN not in Chemline 3/87	1.99	1	0
3-propoxy-beta-carboline 3-propoxy-beta-carboline: structure in first source	1.99	1	0
harman harman: a beta-carboline; RN given refers to parent cpd; structure. harman : An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.	1.99	1	0	harmala alkaloid; indole alkaloid fundamental parent; indole alkaloid	anti-HIV agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; plant metabolite
1-Ethyl-9H-pyrido[3,4-b]indole [no description available]	1.99	1	0	harmala alkaloid
sk&f 102698 [no description available]	1.99	1	0

Condition	Relationship Strength	Studies
Delayed Effects, Prenatal Exposure [description not available]	1.98	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.38	2
Experimental Neoplasms [description not available]	1.97	1
Carcinoma, Epidermoid [description not available]	1.97	1
Papilloma, Squamous Cell [description not available]	1.97	1
Dermatoses [description not available]	1.97	1
Cancer of Skin [description not available]	2.38	2
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.97	1
Hypertrophy General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).	1.97	1
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	1.97	1
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	1.97	1
Skin Neoplasms Tumors or cancer of the SKIN.	2.38	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.37	2
Fibromatosis [description not available]	1.97	1
Atypical Lipoma [description not available]	1.97	1
Experimental Hepatoma [description not available]	2.37	2
Fibroma A benign tumor of fibrous or fully developed connective tissue.	1.97	1
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	1.97	1
Lipoma A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.	1.97	1

1,2,3,4,7,8-hexachlorodibenzofuran

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Research Excerpts

Toxicity

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Drug Classes (1)

Protein Targets (2)

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Biological Processes (22)

Molecular Functions (16)

Ceullar Components (10)

Bioassays (1)

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Studies (9)

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Research Demand Index: 12.10

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