cellular response to 2,3,7,8-tetrachlorodibenzodioxine

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]

Cellular response to 2,3,7,8-tetrachlorodibenzodioxine (TCDD) is a complex process involving multiple signaling pathways and molecular mechanisms. TCDD, a potent environmental toxin, exerts its effects primarily through the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. Upon binding to TCDD, AhR undergoes a conformational change, dissociates from its chaperone proteins, and translocates to the nucleus. In the nucleus, AhR forms a heterodimer with the aryl hydrocarbon receptor nuclear translocator (ARNT), a process facilitated by the presence of co-chaperone proteins such as heat shock protein 90 (HSP90). This heterodimer binds to specific DNA sequences known as dioxin response elements (DREs) located in the regulatory regions of target genes.

The activation of AhR-ARNT complex leads to the transcriptional induction of a wide range of genes involved in various biological processes. Some of the key target genes include cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), and glutathione S-transferase (GST), enzymes involved in detoxification and xenobiotic metabolism. The upregulation of these enzymes can enhance the metabolism of various compounds, potentially leading to increased oxidative stress and cellular damage.

TCDD exposure can also trigger a cascade of events that affect cell growth, differentiation, and apoptosis. It has been shown to induce cell cycle arrest, promote cell death, and alter cellular signaling pathways involved in inflammatory responses. The precise mechanisms underlying these effects are still being investigated, but it is believed that TCDD disrupts the balance of various intracellular signaling molecules, such as mitogen-activated protein kinases (MAPKs) and NF-κB, which are involved in cell survival and inflammatory responses.

Moreover, TCDD has been implicated in the development of various human diseases, including cancer, immune dysregulation, and reproductive toxicity. The specific molecular mechanisms involved in these disease processes are still being elucidated, but it is clear that TCDD can significantly disrupt the normal function of cells and tissues, leading to adverse health effects.

In summary, the cellular response to TCDD is a multifaceted process that involves the activation of the AhR signaling pathway, leading to the transcriptional induction of target genes, modulation of cellular signaling pathways, and potentially contributing to the development of various diseases. The precise molecular mechanisms involved are still being unraveled, but it is clear that TCDD can have significant impact on cell function and health.'
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Proteins (2)

Compounds (79)