| Assay ID | Title | Year | Journal | Article |
|---|
| AID375528 | Antagonist activity at human recombinant urotensin 2 receptor expressed in CHO cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization at up to 10 uM | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
| Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists. |
| AID1182037 | Competitive antagonist activity at UT receptor in rat aorta assessed as effect on urotensin-2-induced contraction | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14
| Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. |
| AID1714268 | Agonist activity at U-IIR in pig aorta VSMC assessed as increase of ERK1/2 phosphorylation at 500 nM incubated for 15 mins by Western blot analysis relative to control | 2016 | Journal of medicinal chemistry, 11-23, Volume: 59, Issue:22
| Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist. |
| AID1714269 | Agonist activity at U-IIR in pig aorta VSMC assessed as increase of ERK1/2 phosphorylation at 5 nM incubated for 15 mins by Western blot analysis relative to control | 2016 | Journal of medicinal chemistry, 11-23, Volume: 59, Issue:22
| Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist. |
| AID1572000 | Agonist activity at urotensin 2 receptor (unknown origin) expressed in HEK293 cells co-expressing Gq-polycistronic BRET biosensor assessed as induction of Gq activation measured for 5 mins by luminescence detection based BRET assay relative to URP | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. |
| AID1182036 | Agonist activity at UT receptor in rat aorta assessed as contraction relative to urotensin-2 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14
| Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. |
| AID1182035 | Agonist activity at UT receptor in rat aorta assessed as contraction | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14
| Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. |
| AID1182034 | Displacement of [125I]urotensin-2 from human recombinant UT receptor expressed in CHO-K1 cells by scintillation counting method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14
| Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. |
| AID1714272 | Agonist activity at U-IIR in pig aorta VSMC assessed as increase of ERK1/2 phosphorylation incubated for 15 mins by Western blot analysis relative to control | 2016 | Journal of medicinal chemistry, 11-23, Volume: 59, Issue:22
| Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist. |
| AID1310776 | Partial agonist activity at UT2 receptor in Sprague-Dawley rat thoracic aorta ring assessed as induction of aortic contractions at 10 to 100 uM relative to KCl | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity. |
| AID1571995 | Displacement of [125I]-URP or human [125I[-urotensin-2 from human urotensin 2 receptor expressed in HEK293 or CHOK1 cells after 2 hrs by gamma-counting assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. |
| AID375521 | Antagonist activity at human recombinant urotensin 2 receptor expressed in CHO cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
| Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists. |
| AID1571996 | Agonist activity at urotensin 2 receptor in Sprague-Dawley rat thoracic aortic ring assessed as induction of contraction relative to KCl-induced contraction | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. |
| AID1571999 | Agonist activity at urotensin 2 receptor (unknown origin) expressed in HEK293 cells co-expressing Gq-polycistronic BRET biosensor assessed as induction of Gq activation measured for 5 mins by luminescence detection based BRET assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |