Page last updated: 2024-12-09

Methyl nigakinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,5-dimethoxycanthin-6-one: an active metabolite of Picrasma quassiodes; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID638215
CHEMBL ID2386324
CHEBI ID80849

Synonyms (20)

Synonym
6h-indolo(3,2,1-de)(1,5)naphthyridin-6-one, 4,5-dimethoxy-
methyl nigakinone
6h-indolo[3,2,1-de][1,5]naphthyridin-6-one, 4,5-dimethoxy-
inchi=1/c16h12n2o3/c1-20-14-12-13-10(7-8-17-12)9-5-3-4-6-11(9)18(13)16(19)15(14)21-2/h3-8h,1-2h
C16996
18110-87-7
4,5-dimethoxycanthin-6-one
chebi:80849 ,
CHEMBL2386324
DTXSID90171076
AKOS032948585
3,4-dimethoxy-1,6-diazatetracyclo[7.6.1.0^{5,16.0^{10,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one
Q27151344
3,4-dimethoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one
MS-23973
B0005-171424
E80581
CS-0017767
HY-N1882
PD196219
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
beta-carbolinesAny pyridoindole containing a beta-carboline skeleton and their hydrogenated derivatives
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID751085Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID751079Cytotoxicity against human A2780 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID751080Cytotoxicity against human Bel7402 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1080741Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral replication at 50 ug/mL in presence of 25 ug/mL quassinoid nigakilactone B measured 48 hr after compound exposure by half leaf met2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID751081Cytotoxicity against human BGC823 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID751078Cytotoxicity against human HCT8 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1320173Cerebral protective activity in cerebral ischemia-induced Mongolian gerbil assessed as passive avoidance test value at 100 mg/kg, po pretreated for 30 mins followed by bilateral ligation-induced ischemia for 5 mins measured on day 1 post 3 days ischemia i2016Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
Evaluation of canthinone alkaloids as cerebral protective agents.
AID751082Cytotoxicity against human A549 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1320174Cerebral protective activity in anesthetized cerebral ischemia-induced Mongolian gerbil hippocampus assessed as protective values on density of surviving neurons in CA1 subfields of hippocampus at 100 mg/kg, po pretreated for 30 mins followed by bilateral2016Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
Evaluation of canthinone alkaloids as cerebral protective agents.
AID1080735Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication in presence of 25 ug/mL quassinoid nigakilactone B measured 48 hr after compound exposure by leaf-disk method2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID751084Antioxidant activity in rat liver microsome assessed as inhibition of Fe2+-cysteine-induced lipid peroxidation after 15 mins2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1194597Inhibition of PTP1B (unknown origin) assessed as inhibition rate at 100 uM2015Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9
Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.
AID1080739Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication at 50 ug/mL in presence of 25 ug/mL quassinoid nigakilactone B measured 48 hr after compound exposure by leaf-d2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID1080738Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral infection at 50 ug/mL using compound pre-treated virus suspension in presence of 25 ug/mL quassinoid nigakilactone B measured 5 to2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID1080740Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication at 50 ug/mL measured 48 hr after compound exposure by leaf-disk method2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID1080736Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication measured 48 hr after compound exposure by leaf-disk method2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID1080737Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral infection at 50 ug/mL using compound pre-treated virus suspension measured 5 to 6 days after compound exposure2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
AID1080742Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral replication at 50 ug/mL measured 48 hr after compound exposure by half leaf method2009Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.28 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]