Compounds > mansonone e
Page last updated: 2024-12-07

mansonone e

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Mansonone E is a natural product isolated from the fruits of *Garcinia mangostana*, commonly known as mangosteen. It exhibits a range of biological activities, including anti-inflammatory, anti-cancer, and antioxidant properties. The compound's structure contains a unique tetracyclic system, which is responsible for its biological activity. Mansonone E has been shown to inhibit the growth of various cancer cell lines, including leukemia, breast, and colon cancer cells. Research on Mansonone E focuses on its potential as a therapeutic agent for cancer treatment, as well as its potential use in developing new anti-inflammatory and antioxidant drugs.'

mansonone E: a potent anti-bacterial sesquiterpenoid isolated from the dried root bark of Ulmus pumila; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
UlmusgenusA plant genus of the family ULMACEAE that is susceptible to Dutch elm disease which is caused by the ASCOMYCOTA fungus, Ophiostoma.[MeSH]UlmaceaeA plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. Members are trees and shrubs of temperate regions that have watery sap and alternate leaves which are lopsided at the base. The flowers lack petals.[MeSH]

Cross-References

ID SourceID
PubMed CID94303
CHEMBL ID362672
SCHEMBL ID7755715
MeSH IDM0480531

Synonyms (14)

Synonym
5090-87-9
naphtho[1,8-bc]pyran-7,8-dione, 2,3-dihydro-3,6,9-trimethyl-
mansonone e
CHEMBL362672
3,6,9-trimethyl-2,3-dihydrobenzo[de]chromene-7,8-dione
naphtho(1,8-bc)pyran-7,8-dione, 2,3-dihydro-3,6,9-trimethyl-
SCHEMBL7755715
2,3-dihydro-3,6,9-trimethylnaphtho[1,8-bc]pyran-7,8-dione
SYWTYRLIJCHSLJ-UHFFFAOYSA-N
3,6,9-trimethyl-2,3-dihydrobenzo[de]chromene-7,8-dione #
bdbm50493328
DTXSID40965144
3,6,9-trimethyl-2,3-dihydronaphtho[1,8-bc]pyran-7,8-dione
4,8,12-trimethyl-2-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8-tetraene-10,11-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA topoisomerase 2-alphaHomo sapiens (human)IC50 (µMol)18.60000.48004.35649.9400AID770642
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
hematopoietic progenitor cell differentiationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topological changeDNA topoisomerase 2-alphaHomo sapiens (human)
DNA ligationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA damage responseDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome segregationDNA topoisomerase 2-alphaHomo sapiens (human)
female meiotic nuclear divisionDNA topoisomerase 2-alphaHomo sapiens (human)
apoptotic chromosome condensationDNA topoisomerase 2-alphaHomo sapiens (human)
embryonic cleavageDNA topoisomerase 2-alphaHomo sapiens (human)
regulation of circadian rhythmDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of apoptotic processDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediateDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIDNA topoisomerase 2-alphaHomo sapiens (human)
rhythmic processDNA topoisomerase 2-alphaHomo sapiens (human)
negative regulation of DNA duplex unwindingDNA topoisomerase 2-alphaHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA topoisomerase 2-alphaHomo sapiens (human)
sister chromatid segregationDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
magnesium ion bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
chromatin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
RNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityDNA topoisomerase 2-alphaHomo sapiens (human)
protein kinase C bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP-dependent activity, acting on DNADNA topoisomerase 2-alphaHomo sapiens (human)
DNA binding, bendingDNA topoisomerase 2-alphaHomo sapiens (human)
protein homodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
ubiquitin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein heterodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
nuclear chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
centrioleDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome, centromeric regionDNA topoisomerase 2-alphaHomo sapiens (human)
condensed chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
male germ cell nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
cytoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complexDNA topoisomerase 2-alphaHomo sapiens (human)
protein-containing complexDNA topoisomerase 2-alphaHomo sapiens (human)
ribonucleoprotein complexDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID344237Cytotoxicity against human HT29 cells by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
AID1322212Antibacterial activity against Propionibacterium acnes KCCM 41747 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322214Antibacterial activity against Salmonella typhi ATCC 422 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322210Antibacterial activity against Streptococcus sobrinus KCCM 11898 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322217Antibacterial activity against Streptococcus mutans ATCC 25175 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID386973Oxidation of dihydrolipoamide assessed as oxygen consumption at 50 uM2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID249270Minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.
AID1322220Antibacterial activity against Salmonella typhi ATCC 422 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322216Antibacterial activity against Staphylococcus aureus ATCC 25923 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID344235Cytotoxicity against human MCF7 cells by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
AID751081Cytotoxicity against human BGC823 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID751082Cytotoxicity against human A549 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID249334Minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.
AID770634Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Oct, Volume: 68Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
AID751085Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1322208Antibacterial activity against Streptococcus mutans ATCC 25175 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID344239Antibacterial activity against Bacillus subtilis2008Journal of natural products, Jul, Volume: 71, Issue:7
Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
AID1322206Antibacterial activity against Staphylococcus aureus ATCC 25923 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID751080Cytotoxicity against human Bel7402 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID344236Cytotoxicity against human HeLa cells by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
AID386974Antitrypanosomal activity against Leptomonas seymouri2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID386972Oxidation of dithiothreitol assessed as oxygen consumption at 50 uM2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID751079Cytotoxicity against human A2780 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID344238Cytotoxicity against human KB cells by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
AID1322218Antibacterial activity against Streptococcus sobrinus KCCM 11898 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID386975Antitrypanosomal activity against Crithidia fasciculata2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID751078Cytotoxicity against human HCT8 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID770635Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Oct, Volume: 68Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
AID1322219Antibacterial activity against Propionibacterium acnes KCCM 41747 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID770636Cytotoxicity against human K562 cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Oct, Volume: 68Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
AID751084Antioxidant activity in rat liver microsome assessed as inhibition of Fe2+-cysteine-induced lipid peroxidation after 15 mins2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID770642Inhibition of human DNA topoisomerase 2alpha using pBR322 DNA after 30 mins by agarose gel electrophoresis2013European journal of medicinal chemistry, Oct, Volume: 68Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
AID770638Cytotoxicity against human A549 cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Oct, Volume: 68Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's6 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.23 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gossypol
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.		2.0410
beta-lapachone
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.		2.0410benzochromenone;
orthoquinones		anti-inflammatory agent;
antineoplastic agent;
plant metabolite
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.1310C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0210glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.0810alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
mansonone c
mansonone C: structure in first source		2.99401,2-naphthoquinones;
sesquiterpenoid
etoposide
[no description available]		2.0810beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.08101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
alpha-lapachone
alpha-lapachone: structure in first source		2.0410organic heterotricyclic compound;
organooxygen compound
mansonone f
mansonone F: a potent anti-bacterial sesquiterpenoid; structure in first source		2.4320
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.1710cyclodextrin
7-hydroxycadalin
7-hydroxycadalin: isolated from Heterotheca inuloides; structure in first source		2.4620sesquiterpenoid
mansonone g
[no description available]		2.1310
Methyl nigakinone
4,5-dimethoxycanthin-6-one: an active metabolite of Picrasma quassiodes; structure in first source		2.0810beta-carbolines
sesquiterpenes
[no description available]		3.3360
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.3360
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0710benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
B16 Melanoma
[description not available]		02.1710