Compounds > n-benzylformamide
Page last updated: 2024-12-07

n-benzylformamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

N-Benzylformamide is a colorless liquid with a faint, sweet odor. It is used as a solvent and as an intermediate in the synthesis of other chemicals. It is also used as a reagent in the preparation of pharmaceuticals and other fine chemicals. N-Benzylformamide is a versatile compound that has attracted interest in various research areas. For example, it has been investigated as a potential reagent for the synthesis of various organic compounds, including pharmaceuticals and pesticides. N-Benzylformamide has also been explored as a potential solvent for various reactions and processes due to its high boiling point and low toxicity. N-Benzylformamide is often studied due to its potential applications in various industries, including pharmaceuticals, agriculture, and chemical manufacturing. Research efforts focus on understanding its chemical properties, exploring its synthetic routes, and evaluating its potential as a solvent and reagent. It is also investigated for its environmental impact and safety considerations.'

Cross-References

ID SourceID
PubMed CID80654
CHEMBL ID46293
CHEBI ID41117
SCHEMBL ID27354
MeSH IDM0484461

Synonyms (36)

Synonym
AKOS005424501
einecs 228-739-6
unii-l363d92elk
nsc 16247
l363d92elk ,
n-benzylformamide
formamide, n-(phenylmethyl)-
n-(phenylmethyl)formamide
CHEBI:41117 ,
benzyl formamide
nsc16247
nsc-16247
6343-54-0
DB02481
STK263697
n-formylbenzylamine
b2184 ,
n-benzyl-formamide
CHEMBL46293 ,
bdbm50064288
FT-0636108
SCHEMBL27354
n-benzyl formamide
benzylformamide
formamide, n-benzyl-
DTXSID40212842
mfcd00003281
F1984-0386
Q27093469
CS-0009966
D72481
A855417
AS-56889
EN300-748841
SY049324
Z1203730748
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
formamidesAmides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
All-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)Ki0.33000.33001.86503.4000AID34040
Alcohol dehydrogenase 1CHomo sapiens (human)Ki4.90004.90005.05005.2000AID34041
Alcohol dehydrogenase E chainEquus caballus (horse)Ki1.88000.14122.89278.7000AID33855; AID33860
Alcohol dehydrogenase S chainEquus caballus (horse)Ki1.88000.14122.89278.7000AID33855; AID33860
Alcohol dehydrogenase 1AHomo sapiens (human)Ki31.00002.30002.30002.3000AID34039
Retinal dehydrogenase 1 Rattus norvegicus (Norway rat)Ki31.00002.30002.30002.3000AID34039
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (12)

Processvia Protein(s)Taxonomy
retinoid metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
retinoic acid metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
retinol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
retinoic acid metabolic processAlcohol dehydrogenase 1CHomo sapiens (human)
retinol metabolic processAlcohol dehydrogenase 1CHomo sapiens (human)
alcohol metabolic processAlcohol dehydrogenase 1AHomo sapiens (human)
retinoic acid metabolic processAlcohol dehydrogenase 1AHomo sapiens (human)
retinol metabolic processAlcohol dehydrogenase 1AHomo sapiens (human)
retinoid metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
ethanol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cellular aldehyde metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
fatty acid omega-oxidationAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
retinol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol catabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
quinone metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
formaldehyde catabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
retinoid metabolic processAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
response to bacteriumAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
fatty acid omega-oxidationAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
response to ethanolAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
retinoic acid metabolic processAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
retinol metabolic processAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
alcohol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
zinc ion bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
alcohol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1CHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1CHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAlcohol dehydrogenase 1CHomo sapiens (human)
zinc ion bindingAlcohol dehydrogenase 1CHomo sapiens (human)
alcohol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1AHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAlcohol dehydrogenase 1AHomo sapiens (human)
protein bindingAlcohol dehydrogenase 1AHomo sapiens (human)
butanol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1AHomo sapiens (human)
zinc ion bindingAlcohol dehydrogenase 1AHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1AHomo sapiens (human)
NADPH:quinone reductase activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
aldose reductase (NADPH) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
all-trans retinal bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
protein bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
zinc ion bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
benzaldehyde dehydrogenase [NAD(P)+] activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
retinol bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
NAD bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
aldehyde oxidase activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
retinol bindingAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
ethanol bindingAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
receptor antagonist activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
omega-hydroxydecanoate dehydrogenase activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
zinc ion bindingAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
nucleoplasmAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
plasma membraneAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
nucleoplasmAlcohol dehydrogenase 1CHomo sapiens (human)
cytosolAlcohol dehydrogenase 1CHomo sapiens (human)
plasma membraneAlcohol dehydrogenase 1CHomo sapiens (human)
cytosolAlcohol dehydrogenase 1CHomo sapiens (human)
nucleoplasmAlcohol dehydrogenase 1AHomo sapiens (human)
cytosolAlcohol dehydrogenase 1AHomo sapiens (human)
plasma membraneAlcohol dehydrogenase 1AHomo sapiens (human)
cytosolAlcohol dehydrogenase 1AHomo sapiens (human)
nucleoplasmAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
plasma membraneAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID33860Inhibition of horse liver alcohol dehydrogenase activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34042Inhibition of human alcohol dehydrogenase pi activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34044Inhibition of human alcohol dehydrogenase sigma activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34039Inhibition of human alcohol dehydrogenase alpha activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34041Inhibition of human alcohol dehydrogenase gamma2 activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID1691499Inhibition of human mEH at 50 uM using CMNGC as substrate preincubated for 5 mins followed by substrate addition and measured at 30 secs interval for 10 mins by fluorescence assay relative to control2020European journal of medicinal chemistry, May-01, Volume: 193Development of potent inhibitors of the human microsomal epoxide hydrolase.
AID33855Inhibitory activity against horse liver alcohol dehydrogenase (ADH)1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase.
AID34040Inhibition of human alcohol dehydrogenase beta 1 activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.28 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index30.00 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		2.110monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
pyrazole
1H-pyrazole : The 1H-tautomer of pyrazole.		1.9610pyrazole
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		2.1510phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
2,2'-dipyridyl
2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.		2.1510bipyridinechelator;
ferroptosis inhibitor
fomepizole
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.		1.9610pyrazolesantidote;
EC 1.1.1.1 (alcohol dehydrogenase) inhibitor;
protective agent
iodoacetamide
[no description available]		1.9610
aniline
[no description available]		2.110anilines;
primary arylamine
acrylamide
[no description available]		1.9610acrylamides;
N-acylammonia;
primary carboxamide		alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin
chloroacetamide
[no description available]		1.9610
methacrylamide
[no description available]		1.9610acrylamides;
primary carboxamide
2-phenylacetamide
2-phenylacetamide: structure. 2-phenylacetamide : A monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2.		1.9610monocarboxylic acid amidemouse metabolite
4-nitroacetanilide
[no description available]		2.2510
fluoroacetamide
2-fluoroacetamide : Acetamide substituted at C-2 by a fluorine atom.		1.96102-fluoroacetamides
2,2-dichloroacetamide
[no description available]		2.4220
n-cyclohexylformamide
[no description available]		1.9910alicyclic compound;
formamides		mouse metabolite
dodecylamine
dodecylamine: RN given refers to parent cpd		2.2510primary aliphatic amine
adenosine diphosphate ribose
Adenosine Diphosphate Ribose: An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.		2.1510ADP-sugarEscherichia coli metabolite;
mouse metabolite
trichloroacetamide
[no description available]		1.9610
1,7-phenanthroline
[no description available]		2.1510phenanthroline
trifluoroacetamide
[no description available]		1.9610
isobutyramide
[no description available]		1.9610carboximidic acid
1,3-diphenyl-2-aminopropane
1,3-diphenyl-2-aminopropane: structure given in the first source		2.2510
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.2510amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
3-oxetanone
[no description available]		2.2510
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.1510organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
t-tucb
[no description available]		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials