Page last updated: 2024-12-06

5-Methyl-1,3,4-thiadiazol-2-amine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

5-Methyl-1,3,4-thiadiazol-2-amine is a heterocyclic compound that has been investigated for its potential biological activities. It is known to exhibit antimicrobial, anti-inflammatory, and analgesic properties. Research has explored its synthesis through various methods, including the reaction of 2-amino-5-methylthiazole with hydrazine hydrate. Studies have focused on understanding its mechanism of action, particularly its ability to inhibit the growth of certain bacteria and fungi. Its potential as a lead compound for the development of new drugs is being explored, prompting continued research into its pharmacological properties.'
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Cross-References

ID SourceID
PubMed CID66949
CHEMBL ID1288960
CHEBI ID194873
SCHEMBL ID282505
SCHEMBL ID21228555

Synonyms (60)

Synonym
BB 0217150
108-33-8
2-amino-5-methylthiadiazole
nsc-137228
wln: t5nn dsj c1 e1
usaf cy-3
1,4-thiadiazole, 2-amino-5-methyl-
2-amino-5-methyl-1,4-thiadiazole
1,4-thiadiazol-2-amine, 5-methyl-
nsc137228
nsc-526661
nsc526661
5-methyl-1,3,4-thiadiazol-2-amine
amino-5-methyl-1,3,4-thiadiazole
MLS001049227
5-methyl-[1,3,4]thiadiazol-2-ylamine
smr000427775
nsc 137228
matd
2-amino-5-methyl-1,3,4-thiadiazole
1,3,4-thiadiazole, 2-amino-5-methyl-
1,3,4-thiadiazol-2-amine, 5-methyl-
einecs 203-573-7
2-methyl-5-amino-1,3,4-thiadiazole
5-methyl-1,3,4-thiadiazole-2-amine
5-methyl-1,3,4-thiadiazol-2-ylamine
ai3-61163
STK016821
A0874
inchi=1/c3h5n3s/c1-2-5-6-3(4)7-2/h1h3,(h2,4,6)
hmpuhxcguhdvbi-uhfffaoysa-
AKOS000100063
CHEBI:194873
NCGC00246452-01
nc799929em ,
unii-nc799929em
CHEMBL1288960 ,
bdbm50331847
5-amino-2-methyl-1,3,4-thiadiazole
HMS2787M24
PS-4597
FT-0620585
SCHEMBL282505
5-methyl-2 -amino-1,3,4-thiadiazole
5-methyl-2-amino-1,3,4-thiadiazole
2-amino-5- methyl-1,3,4-thiadiazole
amino-5-methyl 1,3,4-thiadiazole
5-methyl-2-amino-1,3,4 -thiadiazole
W-108723
DTXSID70148347
F1423-2916
2-amino-5-methyl-1,3,4-thiadiazole, 97%
mfcd00003110
Z56900928
SY004265
SCHEMBL21228555
AMY3777
CS-0076370
F13849
EN300-17271
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
thiadiazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency0.02390.007215.758889.3584AID588342
gemininHomo sapiens (human)Potency29.09290.004611.374133.4983AID624296
Guanine nucleotide-binding protein GHomo sapiens (human)Potency10.00001.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID756686Activation of AMPKalpha in rat L6 cells assessed as phosphorylation at Thr172 after 40 mins to 24 hrs by Western blot analysis2013Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
AID1852929Redox activity of compound assessed as redox index at 1 uM measured by resazurin assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID554332Inhibition of Leishmania major PTR1 at 5 uM2011Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.
AID1852923Aqueous stability of the compound at pH 7.4 measured after 60 mins by spectrophotometric analysis2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852916Inhibition of recombinant Escherichia coli MurA assessed as residual activity at 500 uM using UDP-N-acetylglucosamine as substrate and measured by malachite green based colorimetric assay relative to control2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID554331Lipophilicity, log D of the compound in octanol buffer at pH 7.42011Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.
AID1852917Inhibition of recombinant Escherichia coli MurA assessed as residual activity at 500 uM using UDP-N-acetylglucosamine as substrate preincubated for 30 mins in presence of 1 mM DTT followed by substrate addition and measured by malachite green based colori2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID756681Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake at 100 uM after 5 hrs in presence of insulin2013Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
AID1852922Inhibition of recombinant Escherichia coli DdlB assessed as residual activity at 500 uM using D-alanine as substrate incubated for 20 mins and measured by malachite green based colorimetric assay relative to control2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852928Redox activity of compound assessed as redox index at 10 uM measured by resazurin assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852927Redox activity of compound assessed as redox index at 100 uM in presence of 100 uM TCEP measured by H2DCFDA assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852930Thiol reactivity of compound at 100 uM measured by DTNB assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852920Inhibition of recombinant SARS-CoV-2 3CLpro expressed in Escherichia coli NiCo21(DE3) assessed as residual activity at 500 uM using DABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 30 mins in presence of 1mM DTT followed by substrate addition and2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID554330Solubility of the compound at pH 7.42011Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.
AID539004Inhibition of Aspergillus fumigatus ChiA1 expressed in Pichia pastoris at 1 mM after 70 mins2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Acetazolamide-based fungal chitinase inhibitors.
AID1852926Redox activity of compound assessed as redox index at 100 uM measured by H2DCFDA assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852915Inhibition of recombinant Escherichia coli MurA assessed as residual activity at 500 uM using UDP-N-acetylglucosamine as substrate preincubated for 30 mins followed by substrate addition and measured by malachite green based colorimetric assay relative to2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID756690Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake at 100 uM after 5 hrs relative to control2013Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
AID1852921Inhibition of Mycobacterium tuberculosis MetAP1a assessed as residual activity at 625 uM using L-methionine 7-amido-4-methylcoumarin as fluorogenic substrate and measured by fluorescence based assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852919Inhibition of recombinant SARS-CoV-2 3CLpro expressed in Escherichia coli NiCo21(DE3) assessed as residual activity at 500 uM using DABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured by FRET assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852931Thiol reactivity of compound measured by TNB2- assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID1852924Redox activity of compound assessed as redox index at 100 uM measured by HRP-PR assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
AID539002Inhibition of Aspergillus fumigatus ChiA1 expressed in Pichia pastoris after 70 mins2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Acetazolamide-based fungal chitinase inhibitors.
AID1852925Redox activity of compound assessed as redox index at 100 uM in presence of 1 mM DTT measured by HRP-PR assay2022ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's6 (66.67)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.22 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.52 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]