Assay ID | Title | Year | Journal | Article |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID756686 | Activation of AMPKalpha in rat L6 cells assessed as phosphorylation at Thr172 after 40 mins to 24 hrs by Western blot analysis | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. |
AID1852929 | Redox activity of compound assessed as redox index at 1 uM measured by resazurin assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID554332 | Inhibition of Leishmania major PTR1 at 5 uM | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. |
AID1852923 | Aqueous stability of the compound at pH 7.4 measured after 60 mins by spectrophotometric analysis | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852916 | Inhibition of recombinant Escherichia coli MurA assessed as residual activity at 500 uM using UDP-N-acetylglucosamine as substrate and measured by malachite green based colorimetric assay relative to control | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID554331 | Lipophilicity, log D of the compound in octanol buffer at pH 7.4 | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. |
AID1852917 | Inhibition of recombinant Escherichia coli MurA assessed as residual activity at 500 uM using UDP-N-acetylglucosamine as substrate preincubated for 30 mins in presence of 1 mM DTT followed by substrate addition and measured by malachite green based colori | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID756681 | Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake at 100 uM after 5 hrs in presence of insulin | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. |
AID1852922 | Inhibition of recombinant Escherichia coli DdlB assessed as residual activity at 500 uM using D-alanine as substrate incubated for 20 mins and measured by malachite green based colorimetric assay relative to control | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852928 | Redox activity of compound assessed as redox index at 10 uM measured by resazurin assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852927 | Redox activity of compound assessed as redox index at 100 uM in presence of 100 uM TCEP measured by H2DCFDA assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852930 | Thiol reactivity of compound at 100 uM measured by DTNB assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852920 | Inhibition of recombinant SARS-CoV-2 3CLpro expressed in Escherichia coli NiCo21(DE3) assessed as residual activity at 500 uM using DABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 30 mins in presence of 1mM DTT followed by substrate addition and | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID554330 | Solubility of the compound at pH 7.4 | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. |
AID539004 | Inhibition of Aspergillus fumigatus ChiA1 expressed in Pichia pastoris at 1 mM after 70 mins | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| Acetazolamide-based fungal chitinase inhibitors. |
AID1852926 | Redox activity of compound assessed as redox index at 100 uM measured by H2DCFDA assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852915 | Inhibition of recombinant Escherichia coli MurA assessed as residual activity at 500 uM using UDP-N-acetylglucosamine as substrate preincubated for 30 mins followed by substrate addition and measured by malachite green based colorimetric assay relative to | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID756690 | Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake at 100 uM after 5 hrs relative to control | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. |
AID1852921 | Inhibition of Mycobacterium tuberculosis MetAP1a assessed as residual activity at 625 uM using L-methionine 7-amido-4-methylcoumarin as fluorogenic substrate and measured by fluorescence based assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852919 | Inhibition of recombinant SARS-CoV-2 3CLpro expressed in Escherichia coli NiCo21(DE3) assessed as residual activity at 500 uM using DABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured by FRET assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852931 | Thiol reactivity of compound measured by TNB2- assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID1852924 | Redox activity of compound assessed as redox index at 100 uM measured by HRP-PR assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
AID539002 | Inhibition of Aspergillus fumigatus ChiA1 expressed in Pichia pastoris after 70 mins | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| Acetazolamide-based fungal chitinase inhibitors. |
AID1852925 | Redox activity of compound assessed as redox index at 100 uM in presence of 1 mM DTT measured by HRP-PR assay | 2022 | ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12
| Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |