Page last updated: 2024-09-03

allosamidin and acetazolamide

allosamidin has been researched along with acetazolamide in 2 studies

*Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) [MeSH]

*Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) [MeSH]

Compound Research Comparison

Studies
(allosamidin)
Trials
(allosamidin)
Recent Studies (post-2010)
(allosamidin)
Studies
(acetazolamide)
Trials
(acetazolamide)
Recent Studies (post-2010) (acetazolamide)
880147,6044951,521

Protein Interaction Comparison

ProteinTaxonomyallosamidin (IC50)acetazolamide (IC50)
Chain A, Class Iii Chitinase Chia1Aspergillus fumigatus A1163164
Carbonic anhydrase 12Homo sapiens (human)0.3178
ReninHomo sapiens (human)8.2
Carbonic anhydrase 1Homo sapiens (human)2.3173
Carbonic anhydrase 2Homo sapiens (human)1.2619
Carbonic anhydrase 2Bos taurus (cattle)0.7
Carbonic anhydrase 3Homo sapiens (human)1.95
Cathepsin BBos taurus (cattle)0.02
Steryl-sulfataseHomo sapiens (human)0.025
Carbonic anhydrase 4Homo sapiens (human)0.1216
Carbonic anhydrase 6Homo sapiens (human)0.2925
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)0.1763
Carbonic anhydrase 7Homo sapiens (human)1.1737
Carbonic anhydrase 9Homo sapiens (human)0.464
ReninMacaca mulatta (Rhesus monkey)8.2
Carbonic anhydrase 13Homo sapiens (human)0.23
Carbonic anhydrase 4Bos taurus (cattle)0.07
Carbonic anhydrase 13Mus musculus (house mouse)0.77
Carbonic anhydrase 14Homo sapiens (human)0.183
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)0.23

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blair, DE; Frearson, JA; Gilbert, IH; Gros, L; Schüttelkopf, AW; van Aalten, DM1
Hurtado-Guerrero, R; van Aalten, DM1

Other Studies

2 other study(ies) available for allosamidin and acetazolamide

ArticleYear
Acetazolamide-based fungal chitinase inhibitors.
    Bioorganic & medicinal chemistry, 2010, Dec-01, Volume: 18, Issue:23

    Topics: Acetazolamide; Amino Acid Sequence; Antifungal Agents; Aspergillus fumigatus; Binding Sites; Chitinases; Crystallography, X-Ray; Enzyme Inhibitors; Fungal Proteins; Molecular Sequence Data; Sequence Alignment; Structure-Activity Relationship

2010
Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors.
    Chemistry & biology, 2007, Volume: 14, Issue:5

    Topics: Acetazolamide; Acetylglucosamine; Amino Acid Sequence; Binding Sites; Chitinases; Cloning, Molecular; Conserved Sequence; Crystallography, X-Ray; Enzyme Inhibitors; Fluorescent Dyes; Glycosides; Hydrogen-Ion Concentration; Hymecromone; Kinetin; Models, Molecular; Molecular Sequence Data; Plants; Purines; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Trisaccharides

2007