Target type: biologicalprocess
The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]
Chitin metabolism is a crucial biological process involving the synthesis, degradation, and modification of chitin, a linear polymer of N-acetylglucosamine (GlcNAc) that serves as a structural component in the cell walls of fungi, exoskeletons of arthropods, and other organisms.
The synthesis of chitin is catalyzed by chitin synthases, which utilize UDP-GlcNAc as a substrate to form long chains of GlcNAc residues. These chains can then be assembled into microfibrils, which are further organized into larger structures such as the chitinous cuticle of insects or the cell walls of fungi.
The degradation of chitin is carried out by chitinases, a group of enzymes that hydrolyze the β-1,4-glycosidic bonds between GlcNAc residues. Chitinases are found in a wide variety of organisms, including bacteria, fungi, plants, and animals, and play important roles in nutrient acquisition, defense against pathogens, and the recycling of chitinous material.
The chitin metabolic process is regulated by various factors, including environmental cues, developmental signals, and the availability of nutrients. This intricate regulation ensures that the synthesis and degradation of chitin are tightly controlled to meet the specific needs of the organism.
In summary, chitin metabolism encompasses the intricate processes of chitin synthesis, degradation, and modification. This process is essential for the survival of many organisms, playing vital roles in structural integrity, nutrient acquisition, defense against pathogens, and other biological functions.'
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Protein | Definition | Taxonomy |
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Acidic mammalian chitinase | An acidic mammalian chitinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZP6] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
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acetazolamide | Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) | monocarboxylic acid amide; sulfonamide; thiadiazoles | anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor |
kinetin | cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects. | 6-aminopurines; furans | cytokinin; geroprotector |
8-chlorotheophylline | organochlorine compound; purines | central nervous system stimulant | |
allosamidin | allosamidin: Anti-Asthmatic | ||
argifin | argifin: possible lead insecticide; isolated from Gliocladium; structure in first source |