SK&F 91488: RN given refers to parent cpd; structure given in first source; PI: APT (80-92) (not an active MH record; now NM) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5227 |
| CHEMBL ID | 1230270 |
| SCHEMBL ID | 12648461 |
| MeSH ID | M0082859 |
| Synonym |
|---|
| CHEMBL1230270 |
| NCGC00024626-01 |
| lopac-s-145 |
| tocris-0512 |
| NCGC00015911-01 |
| LOPAC0_001172 |
| 4DI , |
| 4-(dimethylamino)butyl imidothiocarbamate |
| NCGC00024626-03 |
| sk&f-91488 |
| 4-(dimethylamino)butyl carbamimidothioate |
| sk&f 91488 |
| carbamimidothioic acid, 4-(dimethylamino)butyl ester |
| skf 91488 |
| NCGC00024626-02 |
| DB07106 |
| homodimaprit |
| skf-91488 |
| 68643-23-2 |
| CCG-205246 |
| 1i4lvx494h , |
| unii-1i4lvx494h |
| AKOS006328360 |
| NCGC00015911-02 |
| NCGC00015911-03 |
| NCGC00015911-04 |
| [4-(carbamimidoylsulfanyl)butyl]dimethylamine |
| SCHEMBL12648461 |
| skf 91488 2hcl |
| skf-91488; 4-(-dimethylamino)butyl ester 4(-n,n-dimethylamino)butylisothiourea |
| DTXSID50988329 |
| Q27096020 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 6.3096 | 0.0251 | 20.2376 | 39.8107 | AID886 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 6.3096 | 0.0251 | 20.2376 | 39.8107 | AID886 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 63.0957 | 0.1413 | 37.9142 | 100.0000 | AID1490 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0056 | 0.0010 | 6.0009 | 35.4813 | AID943 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5893 | 0.0200 | 10.7869 | 31.6228 | AID912 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 8 (25.00) | 18.7374 |
| 1990's | 11 (34.38) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 33 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||