morphogen activity

Definition

Target type: molecularfunction

Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. [GOC:go_curators]

Morphogen activity is a molecular function characterized by the ability of a signaling molecule, known as a morphogen, to create a concentration gradient across a developing tissue. This gradient provides positional information, guiding the differentiation of cells into specific cell types and patterns. Morphogens are typically secreted proteins that bind to receptors on target cells, triggering intracellular signaling pathways. The concentration of the morphogen determines the type of response elicited in the target cell. High concentrations of the morphogen activate one set of genes, while lower concentrations activate a different set. This differential gene expression drives the formation of distinct cell types and structures. Morphogens play a crucial role in embryonic development, shaping the body plan and determining the fates of cells in various tissues. Examples of morphogens include Sonic hedgehog, Wnt proteins, and bone morphogenetic proteins (BMPs).'
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Proteins (1)

Compounds (5)