intermediate filament organization

Definition

Target type: biologicalprocess

Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:ai]

Intermediate filament (IF) organization is a complex and dynamic process essential for maintaining cell structure, integrity, and function. IFs are a diverse family of fibrous proteins found in the cytoplasm of eukaryotic cells, forming a network that extends throughout the cell, providing mechanical support, resisting stress, and facilitating cell movement. The assembly of IFs involves a series of intricate steps, beginning with the synthesis of monomeric IF proteins, which are then assembled into dimers, tetramers, and finally into protofilaments. These protofilaments, eight in number, associate laterally to form a filament. The process of IF assembly is regulated by various factors, including phosphorylation, post-translational modifications, and interactions with other cellular components. IFs are highly dynamic structures, constantly undergoing assembly, disassembly, and reorganization to adapt to cellular needs. This dynamic nature is crucial for processes such as cell division, migration, and wound healing. The organization of IFs is also influenced by the interactions between IFs and other cytoskeletal components, such as microtubules and actin filaments. These interactions play a role in regulating cell shape, motility, and organelle positioning. The intricate interplay of these factors ensures proper IF organization, contributing to the overall functionality and integrity of the cell.'
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Proteins (1)

Compounds (5)