Page last updated: 2024-10-24

laminin-1 binding

Definition

Target type: molecularfunction

Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. [GOC:go_curators]

Laminin-1 binding is a molecular function that describes the interaction between laminin-1, a major component of the basement membrane, and other molecules. Laminin-1 is a heterotrimeric protein composed of three polypeptide chains: alpha-1, beta-1, and gamma-1. Its binding to other molecules is crucial for various cellular processes, including cell adhesion, migration, differentiation, and signaling.

Laminin-1 binding can occur through several mechanisms:

1. **Direct Binding:** Some proteins possess specific domains that directly interact with laminin-1. These domains can be located on the surface of the protein, or within a specific region known as a laminin-binding domain. Examples include the integrin family of cell adhesion receptors, which utilize specific domains within their alpha and beta subunits to bind laminin-1.

2. **Indirect Binding:** Other proteins may indirectly bind laminin-1 through intermediary molecules. For instance, a protein might bind to a specific component of the extracellular matrix, which is then connected to laminin-1. This indirect interaction can still be essential for the protein's function and localization.

3. **Cooperative Binding:** In some cases, multiple proteins can bind to laminin-1 simultaneously, forming a complex network of interactions. This cooperative binding can lead to the formation of specialized structures, such as focal adhesions, which are critical for cell-matrix communication.

The specific nature of laminin-1 binding can vary depending on the interacting molecule and the context in which the interaction occurs. However, in all cases, this molecular function plays a crucial role in regulating cellular behavior and maintaining tissue integrity.'
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Proteins (1)

ProteinDefinitionTaxonomy
Sonic hedgehog proteinA sonic hedgehog protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15465]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
jervinejervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structurepiperidines
cyclopaminepiperidinesglioma-associated oncogene inhibitor
cur 61414CUR 61414: inhibits the hedehog signaling pathway; structure in first source
gdc 0449HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activitybenzamides;
monochlorobenzenes;
pyridines;
sulfone
antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
robotnikininrobotnikinin: binds sonic hedgehog protein to block its signaling pathway; structure in first source