striated muscle tissue development

Definition

Target type: biologicalprocess

The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. [CL:0000737, GOC:dph, GOC:mtg_muscle]

Striated muscle tissue development is a complex process involving a series of intricate steps. It begins with the determination of myoblasts, precursor cells that are committed to becoming muscle cells. These myoblasts undergo proliferation and differentiation, transitioning into mature muscle fibers. The differentiation process involves the expression of muscle-specific genes, including those encoding contractile proteins like actin and myosin. Myoblasts fuse together to form multinucleated myotubes, which then mature into muscle fibers. During this fusion process, the myoblasts align in a precise manner, forming the characteristic striations of skeletal and cardiac muscle. The formation of sarcomeres, the fundamental contractile units of muscle, is another key aspect of striated muscle development. Sarcomeres are composed of organized arrays of actin and myosin filaments, which are responsible for muscle contraction. The development of the sarcomere involves the assembly of these filaments into precise structures. The process also involves the formation of the sarcoplasmic reticulum, a specialized network of intracellular membranes that regulate calcium levels, essential for muscle contraction. This intricate process of striated muscle development is highly regulated by various signaling pathways, including the Wnt, Notch, and Hedgehog pathways. These pathways ensure proper timing and coordination of the different steps involved in muscle development. Defects in these pathways can lead to various muscle disorders, highlighting the importance of proper regulation of striated muscle development.'
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Proteins (2)

Compounds (10)