Page last updated: 2024-10-24

cell development

Definition

Target type: biologicalprocess

The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. [GOC:go_curators]

Cell development is a complex and fundamental biological process that encompasses the series of events that transform a single fertilized egg, the zygote, into a multicellular organism. This process is orchestrated by a precise interplay of genetic and environmental factors, and it involves a cascade of coordinated cellular events, including cell growth, division, differentiation, and programmed cell death.

Cell growth refers to the increase in size and mass of individual cells. This process is driven by the synthesis of new cellular components, such as proteins, lipids, and carbohydrates.

Cell division, also known as mitosis, is the process by which a single parent cell divides into two daughter cells. Mitosis ensures that each daughter cell receives a complete copy of the parent cell's genetic material.

Cell differentiation is the process by which cells become specialized for specific functions. This involves the activation and repression of specific genes that determine the cell's fate.

Programmed cell death, or apoptosis, is a controlled process of cell elimination. This process is essential for the removal of unwanted or damaged cells during development and throughout life.

The process of cell development can be broadly divided into three main stages: embryonic development, postnatal development, and adulthood.

During embryonic development, the zygote undergoes rapid cell division, leading to the formation of a blastocyst. The blastocyst then implants in the uterine wall, and the cells begin to differentiate into various cell types. The three primary germ layers, ectoderm, mesoderm, and endoderm, form during this stage, and these layers give rise to all the different organs and tissues of the body.

Postnatal development refers to the growth and maturation of the organism after birth. During this stage, the cells continue to differentiate and specialize, and the organs and tissues reach their full functional capacity.

In adulthood, cell development is largely focused on the maintenance and repair of tissues. However, some cell types, such as stem cells, continue to divide and differentiate throughout life, enabling the body to regenerate tissues and repair injuries.

Cell development is a highly regulated process that is essential for life. Understanding the molecular mechanisms that control cell development is crucial for developing treatments for diseases such as cancer and birth defects.
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Proteins (2)

ProteinDefinitionTaxonomy
Axin-2An Axin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2T1]Homo sapiens (human)
Sonic hedgehog proteinA sonic hedgehog protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15465]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
jervinejervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structurepiperidines
cyclopaminepiperidinesglioma-associated oncogene inhibitor
cur 61414CUR 61414: inhibits the hedehog signaling pathway; structure in first source
gdc 0449HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activitybenzamides;
monochlorobenzenes;
pyridines;
sulfone
antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
robotnikininrobotnikinin: binds sonic hedgehog protein to block its signaling pathway; structure in first source
xav939XAV939 : A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.

XAV939: selectively inhibits beta-catenin-mediated transcription; structure in first source
(trifluoromethyl)benzenes;
thiopyranopyrimidine
tankyrase inhibitor