cholesterol-protein transferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]. [PMID:8824192, RHEA:59504]

Cholesterol-protein transferase activity involves the transfer of cholesterol molecules from one protein to another. This activity is crucial for various cellular processes, including:

- **Lipid transport and metabolism:** Cholesterol-protein transferases facilitate the movement of cholesterol between different cellular compartments, such as the plasma membrane, endoplasmic reticulum, and Golgi apparatus. This movement is essential for maintaining cholesterol homeostasis and regulating its distribution within the cell.

- **Signaling pathways:** Cholesterol is a key component of cell membranes and plays a role in various signaling pathways. Cholesterol-protein transferases can modulate these pathways by altering the cholesterol content of specific proteins, influencing their function and activity.

- **Protein structure and function:** Cholesterol can interact with proteins, affecting their structure and function. Cholesterol-protein transferases contribute to the appropriate insertion and localization of cholesterol within proteins, ensuring their proper folding and activity.

- **Atherosclerosis:** Abnormal cholesterol metabolism and transport are implicated in the development of atherosclerosis. Cholesterol-protein transferases have been linked to the accumulation of cholesterol in arterial walls, contributing to plaque formation and cardiovascular disease.

- **Neurological function:** Cholesterol plays a vital role in the nervous system, influencing neuronal function and myelin formation. Cholesterol-protein transferases may contribute to the regulation of cholesterol levels in the brain and the maintenance of neurological health.'
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Proteins (1)

Compounds (5)