| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID694766 | Cytotoxicity against HUVEC after 24 hrs by WST-1 assay | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1321072 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli2 expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321053 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321082 | Induction of Renilla reniformis luciferase activity at 10 uM relative to control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321079 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Smo expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID694765 | Cytotoxicity against HUVEC up to 10 uM after 24 hrs by WST-1 assay | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1321063 | Agonist activity at Smo in cerebellar granule cell precursors isolated from rat at postnatal day 8 assessed as stimulation of proliferation by [3H]-thymidine incorporation assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321057 | Induction of mouse C3H10T1/2 cell differentiation into osteoblast at 0.3 uM in presence of smo ShRNA incubated for 6 days by alkaline phosphatase assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID694773 | Induction of angiogenesis in HUVEC assessed as formation of cell sprouts after 48 hrs by BrdU incorporation assay | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1321085 | Agonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as stimulation of Gli transcription factor | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1771774 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. |
| AID502885 | Activation of Shh in ptch1 gene-deficient MEF assessed as beta-galactosidase activity after 30 hrs by chemiluminescence assay in presence of 100 nM 3-keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl cyclopamine | 2006 | Nature chemical biology, Jan, Volume: 2, Issue:1
| Purmorphamine activates the Hedgehog pathway by targeting Smoothened. |
| AID694769 | Activation of Shh pathway in human foreskin fibroblasts assessed as increase in VEGF expression at 0.1 to 1 uM after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1321069 | Induction of Smo translocation to primary cilium in mouse NIH/3T3 cells at 1 uM after overnight incubation by DAPI staining-based immunofluorescence assay relative to control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321071 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli1 expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321054 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 10 uM incubated for 6 days by alkaline phosphatase assay relative to GSA-10 | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1771772 | Agonist activity at SMO in mouse NIH3T3 cells assessed as induction of SMO accumulation in primary cilia incubated for 12 hrs by fluorescence method | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. |
| AID694772 | Induction of HUVEC proliferation after 48 hrs by BrdU-incorporation assay | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1771773 | Agonist activity at SMO in mouse NIH3T3 cells assessed as fluorescent intensity of ciliary SMO incubated for 12 hrs by fluorescence method | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. |
| AID694768 | Activation of Shh pathway in human foreskin fibroblasts assessed as increase in VEGF expression after 48 hrs by ELISA | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1321066 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 0.3 uM in presence of adenylate cyclase activator forskolin incubated for 6 days by alkaline phosphatase assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321062 | Agonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as stimulation of Gli transcription factor incubated for 40 hrs | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321067 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 0.3 uM in presence of phosphodiesterase inhibitor IBMX incubated for 6 days by alkaline phosphatase assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID1321074 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Ptc1 expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID509545 | Agonist activity at hedgehog receptor | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Modulators of the hedgehog signaling pathway. |
| AID694770 | Activation of Shh pathway in human foreskin fibroblasts assessed as induction of maximum VEGF expression at 0.5 uM after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1321073 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli3 expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. |
| AID694763 | Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assay | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID694771 | Activation of Shh pathway in human foreskin fibroblasts assessed as induction of maximum VEGF expression at 1 uM after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Potent small molecule Hedgehog agonists induce VEGF expression in vitro. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |