metanephric mesenchymal cell proliferation involved in metanephros development
Definition
Target type: biologicalprocess
The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population. [GOC:mtg_kidney_jan10]
Metanephric mesenchymal cell proliferation is a critical process in metanephros development, which gives rise to the kidneys. This intricate process involves a cascade of molecular events, including signaling pathways and transcription factor regulation, to ensure the formation of functional nephrons.
The metanephric mesenchyme, a population of undifferentiated mesenchymal cells, is induced by the ureteric bud, an outgrowth from the Wolffian duct. This inductive signal triggers the expression of genes essential for mesenchymal cell proliferation and differentiation.
One of the key signaling pathways involved is the Wnt pathway, which plays a crucial role in regulating cell fate decisions and proliferation. Activation of Wnt signaling within the metanephric mesenchyme promotes proliferation and maintains the pool of undifferentiated cells.
Another important signaling pathway is the fibroblast growth factor (FGF) pathway, particularly FGF2, which promotes the proliferation and survival of metanephric mesenchymal cells. FGF signaling also regulates the expression of genes involved in mesenchymal condensation, a process where mesenchymal cells aggregate to form the pre-tubular aggregates.
Transcription factors, such as Pax2, Six2, and Eya1, are crucial for regulating gene expression and guiding the differentiation of metanephric mesenchymal cells. These factors interact with each other and with signaling pathways to orchestrate the complex process of nephron formation.
The metanephric mesenchymal cells undergo a series of steps during proliferation and differentiation. First, they condense to form pre-tubular aggregates. Within these aggregates, cells differentiate into epithelial cells, which then organize into tubules, the functional units of the kidney.
The regulation of metanephric mesenchymal cell proliferation is tightly controlled. Factors such as growth factors, signaling pathways, and transcription factors interact in a complex network to ensure that the appropriate number of cells proliferate and differentiate to form functional nephrons.
This intricate process is essential for the development of healthy kidneys. Disruptions in metanephric mesenchymal cell proliferation can lead to kidney malformations and diseases.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Sonic hedgehog protein | A sonic hedgehog protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15465] | Homo sapiens (human) |
| Signal transducer and activator of transcription 1-alpha/beta | A signal transducer and activator of transcription 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P42224] | Homo sapiens (human) |
Compounds (11)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| suramin sodium | suramin sodium : An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. | organic sodium salt | angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug |
| jervine | jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure | piperidines | |
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| nsc 74859 | NSC 74859: inhibits Stat3 binding activity; structure in first source S3I-201 : An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid. | amidobenzoic acid; monohydroxybenzoic acid; tosylate ester | STAT3 inhibitor |
| cyclopamine | piperidines | glioma-associated oncogene inhibitor | |
| nf 449 | |||
| cur 61414 | CUR 61414: inhibits the hedehog signaling pathway; structure in first source | ||
| 5,15-diphenylporphine | 5,15-diphenylporphine: structure in first source | ||
| guttiferone k | guttiferone K: antiproliferative compound of Rheedia calcicola from the Madagascar rain forest; structure in first source | ||
| gdc 0449 | HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity | benzamides; monochlorobenzenes; pyridines; sulfone | antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist; teratogenic agent |
| robotnikinin | robotnikinin: binds sonic hedgehog protein to block its signaling pathway; structure in first source |