deoxyartemisinin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

deoxyartemisinin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	12814879
CHEMBL ID	331309
SCHEMBL ID	23598552
MeSH ID	M0155666
PubMed CID	44347173
MeSH ID	M0155666

Synonyms (22)

Synonym
CHEMBL331309
artemisinin, deoxy
j59t2407wz ,
10ah-9,10b-epoxypyrano(4,3,2-jk)(2)benzoxepin-2(3h)-one, octahydro-3,6,9-trimethyl-, (3r-(3alpha,3abeta,6beta,6abeta,9beta,10aalpha,10bbeta))-
unii-j59t2407wz
72826-63-2
hydroarteannuin
deoxy artemisinin
qing hau sau iii
desoxyartemisinin
qinghaosu iii
(3r,3as,3a1r,6r,6as,9s,10as)-3,6,9-trimethyldecahydro-2h-3a1,9-epoxyoxepino(4,3,2-ij)isochromen-2-one
2-deoxyartemisinin
(3r,3as,6r,6as,9s,10as,10br)-octahydro-3,6,9-trimethyl-10ah-9,10b-epoxypyrano[4,3,2-jk][2]benzoxepin-2(3h)-one, aldrichcpr
AKOS027282466
(3r,3as,3a1r,6r,6as,9s,10as)-3,6,9-trimethyldecahydro-2h-3a1,9-epoxyoxepino[4,3,2-ij]isochromen-2-one
(1s,4s,5r,8s,9r,12s,13r)-1,5,9-trimethyl-11,14,15-trioxatetracyclo[10.2.1.04,13.08,13]pentadecan-10-one
Q27281229
SCHEMBL23598552
CS-W014047
HY-W013331
deoxyartemisinin

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
"80 h(-1) with an elimination half-life (T½) of 51."	( Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice. Acquaah-Mensah, GK; Elfawal, MA; Rich, SM; Towler, MJ; Weathers, PJ, 2014)	0.4

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay ID	Title	Year	Journal	Article
AID372375	Antiparasitic activity against artemisinin-resistant Toxoplasma gondii STL500-10A infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.
AID151204	Relative activity compared to artemisinin against Plasmodium falciparum Sierra Leone D6	1993	Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26	Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin.
AID341602	Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID341605	Antimicrobial activity against Giardia duodenalis G1	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID372372	Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.
AID151206	Relative activity compared to artemisinin against Plasmodium falciparum Indochina W2	1993	Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26	Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin.
AID402161	Cytotoxicity against mouse EN2 cells after 72 hrs by MTT assay	1997	Journal of natural products, Apr, Volume: 60, Issue:4	Stereochemistry-dependent cytotoxicity of some artemisinin derivatives.
AID158855	Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone)	1988	Journal of medicinal chemistry, Mar, Volume: 31, Issue:3	Arteether, a new antimalarial drug: synthesis and antimalarial properties.
AID158684	In vitro inhibitory activity against Plasmodium falciparum (Sierra leone clone)	1988	Journal of medicinal chemistry, Mar, Volume: 31, Issue:3	Arteether, a new antimalarial drug: synthesis and antimalarial properties.
AID159028	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W2	2002	Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2	Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies.
AID572090	Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
AID372374	Antiparasitic activity against artemisinin-resistant Toxoplasma gondii KN200-6 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.
AID341607	Antimicrobial activity against Babesia divergens 4201	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID372373	Antiparasitic activity against artemisinin-resistant Toxoplasma gondii KN200-1 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.
AID341604	Antimicrobial activity against Giardia duodenalis WB	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID572091	Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
AID341599	Antiplasmodial activity against Plasmodium falciparum K1	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID100591	Antileishmanial activity of compound against leishmania donovani was determined in luciferase assay; Not active	2003	Journal of medicinal chemistry, Sep-25, Volume: 46, Issue:20	Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
AID341600	Antiplasmodial activity against Plasmodium falciparum NF54	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID341598	Antimicrobial activity against Neospora caninum up to 1 ug/ml	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID341603	Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes by axenic assay	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID84804	Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay	2003	Bioorganic & medicinal chemistry letters, Nov-03, Volume: 13, Issue:21	Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells.
AID341606	Antimicrobial activity against Babesia divergens 1903B	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
AID341601	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (8.70)	18.7374
1990's	4 (17.39)	18.2507
2000's	7 (30.43)	29.6817
2010's	10 (43.48)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	29.13 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.82 (4.65)
Search Engine Demand Index	22.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (29.13)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
albendazole [no description available]	2.03	1	aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	anthelminthic drug; microtubule-destabilising agent; tubulin modulator
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.39	2	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	2.03	1	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
mefloquine hydrochloride [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.	2.39	2	organofluorine compound; piperidines; quinolines; secondary alcohol
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	2.01	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
pyrimethamine Maloprim: contains above 2 cpds	2.03	1	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
floxuridine Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.	2.03	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent
melarsoprol Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.	2.03	1	triazines
benzonidazole benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.	2.03	1	C-nitro compound; imidazoles; monocarboxylic acid amide	antiprotozoal drug
artemether Artemether: An artemisinin derivative that is used in the treatment of MALARIA.. artemether : An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	1.97	1	artemisinin derivative; cyclic acetal; organic peroxide; semisynthetic derivative; sesquiterpenoid	antimalarial
atovaquone Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.. atovaquone : A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.	2.03	1	hydroxy-1,2-naphthoquinone
tempol [no description available]	2.05	1	aminoxyls; hydroxypiperidine	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; catalyst; hepatoprotective agent; nephroprotective agent; neuroprotective agent; radical scavenger
anhydrodihydroartemisinin anhydrodihydroartemisinin: structure given in first source	2.01	1
thapsigargin thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.. Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.	2.03	1	butyrate ester; organic heterotricyclic compound; sesquiterpene lactone	calcium channel blocker; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
triacetoneamine-n-oxyl 4-oxo-TEMPO : A member of the class of aminoxyls that is TEMPO carrying an oxo group at position 4.. Triacetoneamine-N-Oxyl: Cyclic N-oxide radical functioning as a spin label and radiation-sensitizing agent.	2.05	1	aminoxyls; piperidones	radical scavenger
tempo TEMPO: structure. TEMPO : A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively.	2.05	1	aminoxyls; piperidines	catalyst; ferroptosis inhibitor; radical scavenger
artemotil artemotil: structure given in first source; RN given refers to cpd without isomeric designation	2.39	2	artemisinin derivative
tempo carboxylic acid tempo carboxylic acid: structure given in first source. 4-carboxy-TEMPO : A member of the class of aminoxyls that is TEMPO carrying a carboxy group at position 4.	2.05	1	aminoxyls; piperidinemonocarboxylic acid	MRI contrast agent; radical scavenger; spin label
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.01	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
artenimol artenimol: derivative of antimalarial drug artemisinin (quinghaosu)	2.91	4
arterolane arterolane: a trioxolane with antimalarial activity; structure in first source. arterolane : An oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine.	2.45	2
artemisone artemisone: second-generation semi-synthetic artemisinin derivative for antimalarial therapy devoid of neurotoxicity	2.03	1
deoxoartemisinin deoxoartemisinin: structure given in first source	2.01	1
sodium artesunate [no description available]	1.97	1
cimetidine cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.. Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.	2.01	1	aliphatic sulfide; guanidines; imidazoles; nitrile	adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor
indomethacin indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.. Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.	2.01	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
nonane nonane : A straight chain alkane composed of 9 carbon atoms.. iotrochotin: toxin from the Caribbean sponge Iotrochota birotulata, which selectively permeabilizes synaptosomes	2.06	1	alkane	plant metabolite; volatile oil component
ferrous oxide [no description available]	2.06	1	iron oxide
artemisinin (+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	4.05	14	organic peroxide; sesquiterpene lactone	antimalarial; plant metabolite
anhydrodihydroartemisinin anhydrodihydroartemisinin: structure given in first source	2.01	1
artemisin [no description available]	2.05	1
carbenoxolone sodium Carbenoxolone: An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.	2.01	1	triterpenoid
sesquiterpenes [no description available]	3.39	7
tempo TEMPO: structure. TEMPO : A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively.	2.05	1	aminoxyls; piperidines	catalyst; ferroptosis inhibitor; radical scavenger
artemotil artemotil: structure given in first source; RN given refers to cpd without isomeric designation	2.1	1	artemisinin derivative
artenimol artenimol: derivative of antimalarial drug artemisinin (quinghaosu)	2.73	3
arterolane arterolane: a trioxolane with antimalarial activity; structure in first source. arterolane : An oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine.	2.45	2
deoxoartemisinin deoxoartemisinin: structure given in first source	2.07	1
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	2.06	1

Condition	Relationship Strength	Studies
Infections, Plasmodium [description not available]	2.71	3
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	2.71	3
Plasmodium falciparum Malaria [description not available]	2.01	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.01	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.01	1
Breast Cancer [description not available]	2.01	1
Carcinoma, Non-Small Cell Lung [description not available]	2.01	1
Cancer of Lung [description not available]	2.01	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.01	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1
Gastric Ulcer [description not available]	2.01	1
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.01	1

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