anhydrodihydroartemisinin profile

anhydrodihydroartemisinin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	393517
CHEMBL ID	279307
MeSH ID	M0237659

Synonyms (23)

Synonym
nsc695575
nsc-695575
anhydrodihydroartemisinin
3r,5as,6r,8as,12r,12ar)-3,4,5,5a,6,7,8,8a-octahydro-3,6,9-trimethyl-3,12-epoxy-12hpyrano[4,3-j]-1,2-benzodioxepin
CHEMBL279307
82596-30-3
anhydro dihydro artemisinin
9,10-anhydrodehydroartemisinin
9,10-anhydro-10-deoxoartemisinin
anhydrodihydroartemisnin
(3r,5as,6r,8as,12r,12ar)-3,4,5,5a,6,7,8,8a-octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin(+)-9,10
0YH8NQO930 ,
3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin, 3,4,5,5a,6,7,8,8a-octahydro-3,6,9-trimethyl-, (3r,5as,6r,8as,12r,12ar)-
unii-0yh8nqo930
artemisinin, anhydrodihydro-
DTXSID50327855
9,10-dehydrodeoxyartemisinin
UKXCIQFCSITOCY-VLDCTWHGSA-N
Q27237351
(1r,4s,5r,8s,12r,13r)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-9-ene
(3r,5as,6r,8as,12r,12ar)-3,6,9-trimethyl-4,5,5a,6,7,8,8a,12-octahydro-3h-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
(1r,4s,5r,8s,12r,13r)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0?,??.0?,??]hexadec-9-ene
AKOS040760837

Research Excerpts

Treatment

Excerpt	Reference	Relevance
"When anhydrodihydroartemisinin was treated with a Fe(II) salt in acetonitrile-water solution, the same product was generated, together with an isomeric 2-deoxy-4α-hydroxy-anhydrodihydroartemisinin derivative, as expected from the usual homolytic radical opening of the endoperoxide bond previously described for other artemisinin derivatives."	( A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets. Azerad, R; Bertho, G; Charrier, C; Moneton, P; Petigny, O, )	0.59

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID159028	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W2	2002	Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2	Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.74 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.69 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.74)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
artemisinin (+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	7.41	2	organic peroxide; sesquiterpene lactone	antimalarial; plant metabolite
sesquiterpenes [no description available]	2.69	3
artenimol artenimol: derivative of antimalarial drug artemisinin (quinghaosu)	2.01	1
deoxyartemisinin [no description available]	2.01	1
deoxyartemisinin deoxyartemisinin: structure given in first source	2.01	1

Condition	Relationship Strength	Studies
Allergic Encephalomyelitis [description not available]	2.31	1
Breast Cancer [description not available]	2.01	1
Carcinoma, Non-Small Cell Lung [description not available]	2.01	1
Cancer of Lung [description not available]	2.01	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.01	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1

anhydrodihydroartemisinin

Description