Page last updated: 2024-12-10

tempo carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tempo carboxylic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

4-carboxy-TEMPO : A member of the class of aminoxyls that is TEMPO carrying a carboxy group at position 4. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3080786
CHEMBL ID1673203
CHEBI ID180671
MeSH IDM0140054

Synonyms (26)

Synonym
1-oxyl-4-carboxyl-2,2,6,6-tetramethylpiperidine
tempo carboxylate
1-piperidinyloxy, 4-carboxy-2,2,6,6-tetramethyl-
4-carboxyl-2,2,6,6-tetramethylpiperidin-1-yloxyl
4-carboxyl-2,2,6,6-tetramethylpiperidinoxyl
4-carboxy-2,2,6,6-tetramethylpiperidine-n-oxyl
tca meglumine
tempo carboxylic acid
4-carboxy-2,2,6,6-tetramethylpiperidinyloxyl
CHEBI:180671
2,2,6,6-tetramethyl-4-carboxypiperidine-1-oxyl
4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl
4-carboxy-tempo, free radical, 97%
37149-18-1
4-carboxy-2,2,6,6-tetramethylpiperidine 1-oxyl
4-carboxy-tempo
C1428
FT-0660718
CHEMBL1673203
4-carboxy-tempo, free radical
4-carboxy-2,2,6,6-tetramethylpiperidinyloxy, free radical
4-carboxy-2,2,6,6-tetramethylpiperidine1-oxyl
DTXSID40190631
4-carboxy-2,2,6,6-tetramethylpiperidine 1-oxyl free radical
4-carboxy tempo
AKOS040754948

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Diabetes induced only slight alterations to the pharmacokinetic parameters."( Pharmacokinetic study of tempo carboxylic acid, a nitroxyl MRI contrast media, in control and streptozocin diabetic rats.
Bonnet, PA; Fernandez, JP; Michel, A; Pull, L; Subra, G, 1989
)
0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
radical scavengerA role played by a substance that can react readily with, and thereby eliminate, radicals.
MRI contrast agentnull
spin labelA role played by a stable paramagnetic group that is attached to a part of a molecular entity whose microscopic environment is of interest and may be revealed by the electron spin resonance (ESR) spectroscopy.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
aminoxylsRadicals derived from hydroxylamines by removal of the hydrogen atom from the hydroxy group. The synonymous terms nitroxyl radicals and nitroxides erroneously suggest the presence of a nitro group.
piperidinemonocarboxylic acidAny member of the class of piperidines in which one of the carbons of the piperidine ring is substituted by a carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1537719Antibiofilm activity against Escherichia coli UTI89 incubated for 24 hrs2019MedChemComm, May-01, Volume: 10, Issue:5
Eradicating uropathogenic
AID1537718Antibacterial activity against Escherichia coli UTI89 incubated for 18 hrs in presence of 1:2 ratio of ciprofloxacin to compound by broth microdilution method2019MedChemComm, May-01, Volume: 10, Issue:5
Eradicating uropathogenic
AID572091Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
AID1537720Antibiofilm activity against Escherichia coli UTI89 incubated for 24 hrs in presence of 1:2 ratio of ciprofloxacin to compound2019MedChemComm, May-01, Volume: 10, Issue:5
Eradicating uropathogenic
AID1537717Antibacterial activity against Escherichia coli UTI89 incubated for 18 hrs by broth microdilution method2019MedChemComm, May-01, Volume: 10, Issue:5
Eradicating uropathogenic
AID572090Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (30.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.18 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]