Page last updated: 2024-12-05

n-(2-hydroxyethyl)ethylenediamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

n-(2-hydroxyethyl)ethylenediamine, also known as hydroxyethyl ethylenediamine (HEEDA), is a chelating agent used in a variety of applications, including metal plating, metal cleaning, and as a precursor to other compounds. HEEDA is synthesized by reacting ethylenediamine with ethylene oxide. It is a colorless liquid that is soluble in water. HEEDA is studied because of its ability to complex with metals and its potential use in a variety of applications, including the development of new pharmaceuticals and pesticides.'

N-(2-hydroxyethyl)ethylenediamine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8112
CHEMBL ID3186403
SCHEMBL ID18854
SCHEMBL ID2787111
MeSH IDM0109553

Synonyms (93)

Synonym
BIDD:GT0276
2-(2-aminoethylamino)ethanol
2-((aminoethyl)amino)ethanol
n-aminoethylethanolamine
hsdb 2067
ethanolethylene diamine
1-(2-(hydroxyethyl)amino)-2-aminoethane
nsc 461
ccris 4825
(beta-hydroxyethyl)ethylenediamine
hydroxyethyl ethylenediamine
n-(beta-hydroxyethyl)ethylenediamine
ai3-15368
einecs 203-867-5
2-((2-aminoethyl)amino)ethanol
ethanol, 2-((2-aminoethyl)amino)-
beta-aminoethyl-beta-hydroxyethylamine
n-aminoethyl ethanolamine
brn 0506012
n-(2-hydroxyethyl)ethylenediamine
n-(aminoethyl)ethanolamine
111-41-1
n-(.beta.-aminoethyl)ethanolamine
nsc461
wln: z2m2q
ethanol, 2-[(2-aminoethyl)amino]-
aminoethylethanolamine
1-[2-(hydroxyethyl)amino]-2-aminoethane
monoethanolethylenediamine
(2-hydroxyethyl)ethylenediamine
(2-aminoethyl)ethanolamine
nsc-461
n-(hydroxyethyl)ethylenediamine
n-hydroxyethyl-1,2-ethanediamine
n-(2-hydroxyethyl)-1,2-ethanediamine
2-[(2-aminoethyl)amino]ethanol
n-(2-aminoethyl)ethanolamine
.beta.-aminoethyl-.beta.-hydroxyethylamine
(.beta.-hydroxyethyl)ethylenediamine
n-(.beta.-hydroxyethyl)ethylenediamine
inchi=1/c4h12n2o/c5-1-2-6-3-4-7/h6-7h,1-5h
n-(2-hydroxyethyl)ethylenediamine, 99%
A0299
n-(2-hydroxyethyl)-ethylenediamine
2-[2-aminoethylamino]ethanol
STK802366
NCGC00248562-01
tox21_200209
dtxcid105423
cas-111-41-1
dtxsid7025423 ,
NCGC00257763-01
rc78w6npxt ,
unii-rc78w6npxt
n-hydroxyethylethylenediamine
ec 203-867-5
4-04-00-01558 (beilstein handbook reference)
2-[(2-aminoethyl)amino]ethan-1-ol
FT-0629139
AKOS009156720
2-(2-hydroxyethylamino)ethylamine
2-[(2-aminoethyl)amino]-ethanol
n-hydroxyethyl ethylene diamine
n-(2-hydroxy ethyl)ethylenediamine
(hydroxyethyl)ethylenediamine
n-(2-aminoethyl)-ethanolamine
n-(2-hydroxyethyl)ethylendiamine
n-(beta-hydroxyethyl)-ethylenediamine
n-(2-hydroxy ethyl) ethylenediamine
2-(2-aminoethylamino)-ethanol
n-(beta-aminoethyl) ethanolamine
2-(2-aminoethylamino) ethanol
BBL027690
SCHEMBL18854
hydroxyethylethylenediamine, n-
aminoethyl ethanolamine [hsdb]
aminoethylethanolamine [inci]
SCHEMBL2787111
n-(2'-hydroxyethyl)ethylenediamine
1-aminoethyl ethanolamine
2-amino-2'-hydroxydiethylamine
n-.beta.-hydroxyethylethylenediamine
Q-200137
CHEMBL3186403
F0001-0240
mfcd00008170
aminoethylethanolamin
VS-08576
Q209289
CS-W011299
D77720
A935986
EN300-126824

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" GHS covers many aspects of effects upon health and the environment, including adverse effects upon sexual function and fertility or on development."( Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS).
Boogaard, PJ; Bremer, S; Buesen, R; Edwards, J; Fraysse, B; Hallmark, N; Hemming, H; Hennes, C; Langrand-Lerche, C; McKee, RH; Meisters, ML; Moore, NP; Parsons, P; Politano, V; Reader, S; Ridgway, P, 2013
)
0.39

Dosage Studied

ExcerptRelevanceReference
" Paris, France), in which groups of Wistar rats (10/sex/group) were administered the test substance by gavage at dosage levels of 50, 250, or 1000 mg/kg/day (groups 2-4, respectively)."( Malformations of the great vessels in the neonatal rat induced by N-(2-aminoethyl)ethanolamine.
Moore, NP; Schneider, S; Treumann, S, 2012
)
0.38
" A grading system for the dose-response of DAA lesions associated with AEEA by gavage was established."( Dissecting aortic aneurysm induced by N-(2-aminoethyl) ethanolamine in rat: Role of defective collagen during development.
Boor, PJ; Rossbacher, R; Schneider, S; Treumann, S; Xu, Y, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency34.76110.000657.913322,387.1992AID1259377
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (16.67)18.7374
1990's1 (8.33)18.2507
2000's2 (16.67)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.51 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index38.14 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies1 (8.33%)4.05%
Observational0 (0.00%)0.25%
Other10 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]