| Protein | Synonyms | Taxonomy |
|---|
| Glycoprotein hormones alpha chain | Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; | Homo sapiens (human) |
| Peripheral-type benzodiazepine receptor-associated protein 1 | PRAX-1; Peripheral benzodiazepine receptor-interacting protein; PBR-IP; RIMS-binding protein 1; RIM-BP1; TSPO-associated protein 1 | Homo sapiens (human) |
| Steroid 21-hydroxylase | EC 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B | Homo sapiens (human) |
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase; 1.1.1.270; Delta-5-3-ketosteroid i | Homo sapiens (human) |
| 17-beta-hydroxysteroid dehydrogenase type 1 | 17-beta-HSD 1; EC 1.1.1.51; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; 1.1.1.62; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1 | Homo sapiens (human) |
| Steryl-sulfatase | EC 3.1.6.2; Arylsulfatase C; ASC; Estrone sulfatase; Steroid sulfatase; Steryl-sulfate sulfohydrolase | Homo sapiens (human) |
| Aromatase | EC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase | Homo sapiens (human) |
| Aldo-keto reductase family 1 member B1 | EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; Aldehyde reductase; Aldose reductase; AR; 1.1.1.21 | Homo sapiens (human) |
| Cytochrome P450 11B2, mitochondrial | Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; 1.14.15.5; Cytochrome P-450Aldo; Cytochrome P-450C18; Steroid 11-beta-hydroxylase, CYP11B2; 1.14.15.4; Steroid 18-hydroxylase | Homo sapiens (human) |
| Translocator protein | Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR | Homo sapiens (human) |
| 17-beta-hydroxysteroid dehydrogenase type 2 | 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 2; 1.1.1.62; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogen | Homo sapiens (human) |
| 17-beta-hydroxysteroid dehydrogenase 14 | 17-beta-HSD 14; EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1 | Homo sapiens (human) |
| Steroid 17-alpha-hydroxylase/17,20 lyase | EC 1.14.14.19; 17-alpha-hydroxyprogesterone aldolase; 1.14.14.32; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase | Homo sapiens (human) |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | EC 1.3.1.22; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1 | Homo sapiens (human) |
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-HSD adrenal and gonadal type | Homo sapiens (human) |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | EC 1.3.1.22; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase | Homo sapiens (human) |
| Cholesterol side-chain cleavage enzyme, mitochondrial | EC 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc) | Homo sapiens (human) |
| Corticosteroid-binding globulin | CBG; Serpin A6; Transcortin | Homo sapiens (human) |
| Polyprenol reductase | EC 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; 1.3.1.22; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3; S5AR 3; SR type 3 | Homo sapiens (human) |
| Aldo-keto reductase family 1 member B15 | EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; 1.1.1.216; Testosterone 17beta-dehydrogenase; 1.1.1.64 | Homo sapiens (human) |
| Pro-opiomelanocortin | POMC; Corticotropin-lipotropin | Homo sapiens (human) |
| NADPH:adrenodoxin oxidoreductase, mitochondrial | AR; Adrenodoxin reductase; EC 1.18.1.6; Ferredoxin--NADP(+) reductase; Ferredoxin reductase | Homo sapiens (human) |
| Steroidogenic acute regulatory protein, mitochondrial | StAR; START domain-containing protein 1; StARD1 | Homo sapiens (human) |
| Lutropin subunit beta | Lutropin beta chain; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta | Homo sapiens (human) |
| Estradiol 17-beta-dehydrogenase 11 | EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Deh | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| NADH | |
| cortisone | A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Hydrocortisone | The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. |
| Estradiol | The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. |
| estrone | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. |
| dehydroepiandrosterone | A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. |
| Progesterone | The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS. |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| Testosterone | A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. |
| desoxycorticosterone | A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE |
| pregnenolone | A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| dihydrotestosterone | A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. |
| 18-hydroxycorticosterone | 11 beta,18,21-Trihydroxypregn-4-ene-3,20-dione. |
| isocaproaldehyde | produced from side-chain cleavage of 20,22-dihydroxycholesterol |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| acetaldehyde | A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis. |
| formate | |
| cortodoxone | 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities. |
| aldosterone | A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. |
| 17-alpha-hydroxyprogesterone | A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES. |
| 20,22-dihydroxycholesterol | RN given refers to (3beta,22R)-isomer |
| pregn-5-ene-3,20-dione | |
| 22s-hydroxycholesterol | |
| 17-hydroxypregnenedione | structure |
| corticosterone | An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437) |
| creolin | from refined coal tar oils |
| androstenedione | A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. |
| 17-alpha-hydroxypregnenolone | A 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |