Page last updated: 2024-10-06
Pregnenolone biosynthesis
Proteins (6)
| Protein | Synonyms | Taxonomy |
|---|
| Peripheral-type benzodiazepine receptor-associated protein 1 | PRAX-1; Peripheral benzodiazepine receptor-interacting protein; PBR-IP; RIMS-binding protein 1; RIM-BP1; TSPO-associated protein 1 | Homo sapiens (human) |
| Aldo-keto reductase family 1 member B1 | EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; Aldehyde reductase; Aldose reductase; AR; 1.1.1.21 | Homo sapiens (human) |
| Translocator protein | Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR | Homo sapiens (human) |
| Cholesterol side-chain cleavage enzyme, mitochondrial | EC 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc) | Homo sapiens (human) |
| NADPH:adrenodoxin oxidoreductase, mitochondrial | AR; Adrenodoxin reductase; EC 1.18.1.6; Ferredoxin--NADP(+) reductase; Ferredoxin reductase | Homo sapiens (human) |
| Steroidogenic acute regulatory protein, mitochondrial | StAR; START domain-containing protein 1; StARD1 | Homo sapiens (human) |
Compounds (11)
| Compound | Description |
|---|
| hydronium ion | |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| pregnenolone | A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| isocaproaldehyde | produced from side-chain cleavage of 20,22-dihydroxycholesterol |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| 20,22-dihydroxycholesterol | RN given refers to (3beta,22R)-isomer |
| 22s-hydroxycholesterol | |
| creolin | from refined coal tar oils |