Page last updated: 2024-10-06

Pregnenolone biosynthesis

Proteins (6)

ProteinSynonymsTaxonomy
Peripheral-type benzodiazepine receptor-associated protein 1PRAX-1; Peripheral benzodiazepine receptor-interacting protein; PBR-IP; RIMS-binding protein 1; RIM-BP1; TSPO-associated protein 1Homo sapiens (human)
Aldo-keto reductase family 1 member B1EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; Aldehyde reductase; Aldose reductase; AR; 1.1.1.21Homo sapiens (human)
Translocator proteinMitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBRHomo sapiens (human)
Cholesterol side-chain cleavage enzyme, mitochondrialEC 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)Homo sapiens (human)
NADPH:adrenodoxin oxidoreductase, mitochondrialAR; Adrenodoxin reductase; EC 1.18.1.6; Ferredoxin--NADP(+) reductase; Ferredoxin reductaseHomo sapiens (human)
Steroidogenic acute regulatory protein, mitochondrialStAR; START domain-containing protein 1; StARD1Homo sapiens (human)

Compounds (11)

CompoundDescription
hydronium ion
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
pregnenoloneA 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
isocaproaldehydeproduced from side-chain cleavage of 20,22-dihydroxycholesterol
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
20,22-dihydroxycholesterolRN given refers to (3beta,22R)-isomer
22s-hydroxycholesterol
creolinfrom refined coal tar oils