Page last updated: 2024-12-07
1-nitro-8-nitrosopyrene
Description
1-nitro-8-nitrosopyrene (1N8NP) is a potent mutagen and a suspected human carcinogen.
**Structure and Properties:**
* It is a polycyclic aromatic hydrocarbon (PAH) with two nitro groups attached to its structure, one at the 1 position and one at the 8 position.
* It is a yellow solid with a molecular weight of 268.25 g/mol.
* It is poorly soluble in water but soluble in organic solvents.
**Importance in Research:**
1. **Environmental Carcinogenesis:** 1N8NP is found in various environmental sources such as diesel exhaust, coal tar, and cigarette smoke. Its presence in these sources makes it a significant concern for human health, particularly regarding lung cancer risk.
2. **DNA Damage and Mutation:** 1N8NP is a potent mutagen, meaning it can induce mutations in DNA. Its nitro groups can be metabolically reduced to form reactive intermediates that can bind to DNA, causing base pair substitutions, deletions, and other genetic alterations.
3. **Genotoxicity and Carcinogenicity:** Extensive research has shown that 1N8NP is genotoxic and carcinogenic in various experimental models, including bacteria, mammalian cells, and animals. This makes it a valuable tool for studying the mechanisms of carcinogenesis and for identifying potential anticancer agents.
4. **Mechanism of Action:** Researchers use 1N8NP to investigate the mechanisms by which environmental carcinogens cause cancer. Studies have shown that 1N8NP can activate various signaling pathways involved in cell growth, proliferation, and survival, leading to tumor formation.
5. **Biomarkers of Exposure:** 1N8NP and its metabolites can be used as biomarkers to assess human exposure to environmental pollutants. Measuring levels of these compounds in biological samples like urine or blood can help assess the risk of cancer development.
**Overall, 1N8NP is a critical research tool for understanding the mechanisms of environmental carcinogenesis and for developing strategies to prevent and treat cancer.**
**However, it's important to note that 1N8NP is a dangerous chemical and should only be handled by trained professionals in a controlled laboratory setting.**
1-nitro-8-nitrosopyrene: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 108093 |
| MeSH ID | M0137992 |
Synonyms (7)
| Synonym |
|---|
| 1-nitro-8-nitrosopyrene |
| pyrene, 1-nitro-8-nitroso- |
| ccris 2587 |
| 1-nitroso-8-nitropyrene |
| 100593-23-5 |
| l-nitroso-8-nitropyrene |
| DTXSID90143410 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.46
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.46 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.25 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |