| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion. | 1.99 | 1 | 0 | halide anion;
monoatomic chlorine | cofactor;
Escherichia coli metabolite;
human metabolite |
glycine
[no description available] | 2.03 | 1 | 0 | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical |
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond. | 2.01 | 1 | 0 | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite |
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines. | 2.46 | 2 | 0 | carboxamidine;
guanidines;
one-carbon compound | |
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid. | 2.08 | 1 | 0 | aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
mouse metabolite;
neurotransmitter |
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. | 2.05 | 1 | 0 | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine. | 2.03 | 1 | 0 | L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group. | 3.09 | 5 | 0 | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical |
thiazoles
[no description available] | 2.07 | 1 | 0 | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
glycyl-glycyl-glycine
glycyl-glycyl-glycine : A tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. | 2.03 | 1 | 0 | tripeptide zwitterion;
tripeptide | |
glycylglycine
[no description available] | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | human metabolite |
thioflavin t
thioflavin T: RN given refers to chloride; structure. thioflavine T : An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. | 2.07 | 1 | 0 | organic chloride salt | fluorochrome;
geroprotector;
histological dye |
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. | 2.47 | 2 | 0 | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical |
ursolic acid
[no description available] | 2.13 | 1 | 0 | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite |
betulinic acid
[no description available] | 2.13 | 1 | 0 | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite |
glycyl-glycyl-glycyl-glycine
[no description available] | 2.03 | 1 | 0 | | |
tyrosyltyrosine
tyrosyltyrosine: RN given refers to all-(L)-isomer. tyrosyltyrosine : A dipeptide comprising tyrosine with a tyrosyl residue attached to the alpha-nitrogen.. Tyr-Tyr : Tyrosyltyrosine in which each tyrosine residue has L-configuration. | 2.03 | 1 | 0 | tyrosyltyrosine | Mycoplasma genitalium metabolite |
leucylleucine
Leu-Leu : A dipeptide formed from two L-leucine residues. | 2.03 | 1 | 0 | dipeptide;
L-aminoacyl-L-amino acid zwitterion | human metabolite;
Mycoplasma genitalium metabolite |
phenylalanylphenylalanylamide
[no description available] | 2.03 | 1 | 0 | | |
Trp-Trp
tryptophyltryptophan: an antigelation agent. Trp-Trp : A dipeptide formed from two L-tryptophan residues. | 2.03 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
glycyltryptophan
glycyltryptophan: RN given refers to (L)-isomer. Gly-Trp : A dipeptide formed from glycine and L-tryptophan residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
glycyltyrosine
Gly-Tyr : A dipeptide composed of glycine and L-tyrosine joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide | metabolite |
glycylleucine
Gly-Leu : A dipeptide composed of glycine and L-leucine joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
alanyltyrosine
alanyltyrosine: tyrosine source; RN given refers to (L)-isomer. Ala-Tyr : A dipeptide composed of L-alanine and L-tyrosine joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide | metabolite |
glycyl-l-phenylalanine
glycylphenylalanine: RN given refers to (DL)-isomer. Gly-Phe : A dipeptide formed from glycine and L-phenylalanine residues. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | human metabolite;
metabolite |
glycylsarcosine
glycylsarcosine : A dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | |
alanylphenylalanine
alanylphenylalanine: RN given refers to (L-Ala-L-PheAla)-isomer | 2.03 | 1 | 0 | dipeptide | metabolite |
tryptophylglycine
Trp-Gly : A dipeptide formed from L-tryptophan and glycine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
glycylaspartic acid
glycylaspartic acid: RN given refers to (L)-isomer | 2.03 | 1 | 0 | dipeptide | metabolite |
n-glycylglutamic acid
N-glycylglutamic acid: RN given refers to (L)-isomer. Gly-Glu : A dipeptide formed from glycyl and L-glutamic acid residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
7-amino-4-trifluoromethylcoumarin
coumarin 151: structure in first source | 2.07 | 1 | 0 | 7-aminocoumarins | fluorochrome |
histidylglycine
histidylglycine: RN given refers to all (L)-isomer. His-Gly : A dipeptide formed from L-histidine and glycine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
valylvaline
valylvaline: RN given refers to (L)-isomer. Val-Val : A dipeptide formed from two L-valine residues. | 2.03 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
glycyl-leucyl-phenylalanine
glycyl-leucyl-phenylalanine: an immunostimulatory peptide; RN given refer to all (L)-isomer | 2.03 | 1 | 0 | oligopeptide | |
lysyllysine
lysyllysine: RN given refers to (L-Lys)-isomer. Lys-Lys : A dipeptide formed from two L-lysine residues. | 2.03 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
phenylalanylarginine
phenylalanylarginine: RN given refers to all (L)-isomer. Phe-Arg : A dipeptide composed of L-phenylalanine and L-arginine joined by a peptide linkage. | 2.48 | 2 | 0 | dipeptide | metabolite |
arginylproline
arginylproline: first & second amino acid in substance P sequence; RN given refers to (L)-isomer. Arg-Pro : A dipeptide obtained by formal condensation of the carboxy group of L-arginine with the amino group of L-proline. | 3.86 | 2 | 1 | dipeptide | |
aspartylglycine
Asp-Gly : A dipeptide composed of L-aspartic acid and glycine joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide | metabolite |
leucylarginine
leucylarginine: blocks antinociception induced by L-arginine. Leu-Arg : A dipeptide composed of L-leucine and L-arginine joined by peptide linkages. | 2.08 | 1 | 0 | dipeptide | metabolite |
n-valyltryptophan
N-valyltryptophan: RN given refers to (L)-isomer | 2.03 | 1 | 0 | peptide | |
prolylglutamic acid
Pro-Glu : A dipeptide formed from L-proline and L-glutamic acid residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
bradykinin
[no description available] | 1.93 | 1 | 0 | oligopeptide | human blood serum metabolite;
vasodilator agent |
glutamyl-glutamic acid
glutamyl-glutamic acid: RN given for (L,L)-isomer. Glu-Glu : A dipeptide composed of two L-glutamic acid units joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
aspartyl-aspartic acid
aspartyl-aspartic acid: do not confuse with cyclo(Asp-Asp). Asp-Asp : A dipeptide formed from two L-aspartic acid units. | 2.03 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
n-glycylalanine
Gly-Ala : A dipeptide formed from glycine and L-alanine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
glycylproline
Gly-Pro : A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
glycyllysine
glycyllysine: RN given refers to (L)-isomer. Gly-Lys : A dipeptide formed from glycine and L-lysine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
alanylalanine
L-alanyl-L-alanine : A dipeptide consisting of two L-alanine units joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | Mycoplasma genitalium metabolite |
phenylalanylalanine
phenylalanylalanine: RN given refers to (L)-isomer. Phe-Ala : A dipeptide formed from L-phenylalanine and L-alanine residues. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
alanyltyrosine
Tyr-Ala : A dipeptide formed from L-tyrosine and L-alanine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
prolylglycine
prolylglycine: RN given refers to (L)-isomer. L-prolylglycine : A dipeptide consisting of glycine having an L-prolyl group attached to its alpha-amino nitrogen. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | |
arginyllysine
Arg-Lys : A dipeptide formed from L-arginyl and L-leucine residues. | 2.43 | 2 | 0 | dipeptide | metabolite |
phenylalanylglycine
phenylalanylglycine: RN given refers to (DL)-isomer. Phe-Gly : A dipeptide formed from L-phenylalanine and glycine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
histidylhistidine
histidylhistidine: RN given for L-,L-isomer | 2.03 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
lysylglutamic acid
lysylglutamic acid: a geroprotective agent. Lys-Glu : A dipeptide formed from L-lysine and L-glutamic acid residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
Ala-Lys
Ala-Lys : A dipeptide obtained by formal condensation of the carboxy group of L-alanine with the alpha-amino group of L-lysine. | 2.03 | 1 | 0 | dipeptide | marine metabolite |
arginyl-glutamine
arginyl-glutamine: attenuates hyperoxia-induced lung injury in neonatal mice. Arg-Gln : A dipeptide formed from L-arginyl and L-glutamine residues. | 2.11 | 1 | 0 | dipeptide | metabolite |
valyl-valyl-valine
[no description available] | 2.03 | 1 | 0 | peptide | |
lysylglycine
lysylglycine: structure in first source. Lys-Gly : A dipeptide formed from L-lysine and glycine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
glycylhistidine
glycylhistidine: RN given refers to (L)-isomer. Gly-His : A dipeptide composed of glycine and L-histidine joined by a peptide linkage. | 2.03 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
prolyl-serine
Pro-Ser : A dipeptide formed from L-proline and L-serine residues. | 2.03 | 1 | 0 | dipeptide | metabolite |
prolyl-proline
Pro-Pro : A dipeptide formed from two L-proline residues. | 2.48 | 2 | 0 | dipeptide | human urinary metabolite;
Mycoplasma genitalium metabolite |
cholecystokinin
Cholecystokinin: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety. | 1.99 | 1 | 0 | | |
gastrins
Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters. | 1.99 | 1 | 0 | | |
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group. | 2.07 | 1 | 0 | benzenes;
hydroxycoumarin;
methyl ketone | |
hyaluronoglucosaminidase
Hyaluronoglucosaminidase: An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS. | 2.08 | 1 | 0 | | |