Target type: biologicalprocess
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. [GOC:mah]
Fibroblast growth factors (FGFs) are a family of signaling proteins that play diverse roles in development, cell growth, and tissue repair. The biological process of response to fibroblast growth factor involves a complex cascade of events initiated by the binding of FGFs to their cognate receptors, known as fibroblast growth factor receptors (FGFRs). These receptors are transmembrane proteins with an extracellular domain that binds FGFs and an intracellular domain that activates downstream signaling pathways. Upon FGF binding, FGFRs dimerize and undergo autophosphorylation, creating docking sites for intracellular signaling molecules.
The primary signaling pathways activated by FGFRs are the Ras/MAPK, PI3K/AKT, and PLCĪ³ pathways. The Ras/MAPK pathway promotes cell proliferation and differentiation, while the PI3K/AKT pathway regulates cell survival and growth. The PLCĪ³ pathway is involved in calcium signaling and cytoskeletal rearrangements. These pathways converge to regulate a wide array of cellular processes, including gene expression, protein synthesis, and cellular metabolism.
The response to fibroblast growth factor is highly context-dependent, varying depending on the specific FGF, FGFR, and cell type involved. For example, FGF2 can stimulate proliferation of fibroblasts, while FGF8 is involved in limb development. Different FGFRs exhibit distinct ligand specificities and downstream signaling profiles, contributing to the diverse biological roles of FGFs.
In addition to their role in normal development and tissue homeostasis, FGFs are implicated in various diseases, including cancer, fibrosis, and cardiovascular disease. Aberrant FGF signaling is often associated with tumor growth, angiogenesis, and metastasis. Therapeutic strategies targeting FGF signaling are being explored for the treatment of these diseases.'
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Protein | Definition | Taxonomy |
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Potassium voltage-gated channel subfamily C member 1 | A voltage-gated potassium channel KCNC1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P48547] | Homo sapiens (human) |
Extracellular calcium-sensing receptor | An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
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N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide | naphthalenes; sulfonic acid derivative | ||
5-methoxypsoralen | 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5. 5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS. | 5-methoxyfurocoumarin; organic heterotricyclic compound; psoralens | hepatoprotective agent; plant metabolite |
fendiline | Fendiline: Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents. | diarylmethane | |
cinacalcet hydrochloride | cinacalcet hydrochloride : A hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride. Cinacalcet Hydrochloride: A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES. | hydrochloride | calcimimetic; P450 inhibitor |
cinacalcet | cinacalcet : A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. | (trifluoromethyl)benzenes; naphthalenes; secondary amino compound | calcimimetic; P450 inhibitor |
nps-568 | N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine: NPS-568 is the ((R), HCl salt)-isomer; calcimimetic compound and calcium-sensing receptor agonist | ||
nps-568 | |||
nps2143 | |||
ronacaleret | ronacaleret: a calcium-sensing receptor antagonist; structure in first source |