nps2143 has been researched along with ronacaleret* in 1 studies
1 other study(ies) available for nps2143 and ronacaleret
Article | Year |
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The discovery of novel calcium sensing receptor negative allosteric modulators.
The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis. Topics: Administration, Oral; Allosteric Regulation; Anabolic Agents; Animals; Cell Line; Cyclopropanes; Drug Discovery; Humans; Indans; Microsomes, Liver; Osteoporosis; Phenylpropionates; Rats; Receptors, Calcium-Sensing | 2009 |