nps2143 and ronacaleret

nps2143 has been researched along with ronacaleret* in 1 studies

Other Studies

1 other study(ies) available for nps2143 and ronacaleret

Article	Year
The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12 The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis. Topics: Administration, Oral; Allosteric Regulation; Anabolic Agents; Animals; Cell Line; Cyclopropanes; Drug Discovery; Humans; Indans; Microsomes, Liver; Osteoporosis; Phenylpropionates; Rats; Receptors, Calcium-Sensing	2009

Article

Year

The discovery of novel calcium sensing receptor negative allosteric modulators.

Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12

The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis.

Topics: Administration, Oral; Allosteric Regulation; Anabolic Agents; Animals; Cell Line; Cyclopropanes; Drug Discovery; Humans; Indans; Microsomes, Liver; Osteoporosis; Phenylpropionates; Rats; Receptors, Calcium-Sensing

2009