Page last updated: 2024-10-24

fat pad development

Definition

Target type: biologicalprocess

The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue. [GOC:dph]

Fat pad development is a complex biological process involving the coordinated interplay of various cell types and signaling pathways. It begins with the specification of mesenchymal stem cells (MSCs) in the embryonic mesoderm, which are primed to differentiate into adipocytes, the primary cell type of fat pads. These MSCs undergo a series of developmental steps, including proliferation, migration, and terminal differentiation, ultimately forming mature fat cells.

The process of fat pad development is tightly regulated by a variety of signaling molecules, including growth factors, hormones, and transcription factors. Among these, insulin-like growth factor 1 (IGF-1) plays a crucial role in stimulating MSC proliferation and differentiation. Other important signaling pathways involved include the Wnt, Hedgehog, and PPAR-gamma pathways.

During adipogenesis, MSCs undergo a series of morphological and metabolic changes. They accumulate large lipid droplets, which are essentially stored energy in the form of triglycerides. This accumulation of lipids is facilitated by the expression of specific genes involved in lipid biosynthesis and uptake, such as lipoprotein lipase (LPL).

Fat pad development is not solely driven by adipocyte differentiation; it also involves the formation of a vascular network that supplies oxygen and nutrients to the growing fat tissue. Angiogenesis, the process of blood vessel formation, is essential for the proper development and function of fat pads.

The size and distribution of fat pads vary across different tissues and organs, and their development is influenced by both genetic and environmental factors. For example, the size and distribution of subcutaneous fat, which lies beneath the skin, are influenced by factors such as diet, exercise, and hormonal status.

Overall, fat pad development is a complex and dynamic process that is essential for energy storage, insulation, and other physiological functions. Understanding this process is crucial for developing therapeutic strategies for obesity and other metabolic disorders.'
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Proteins (2)

ProteinDefinitionTaxonomy
Diacylglycerol O-acyltransferase 2A diacylglycerol O-acyltransferase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PD7]Homo sapiens (human)
Extracellular calcium-sensing receptorAn extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180]Homo sapiens (human)

Compounds (10)

CompoundDefinitionClassesRoles
fendilineFendiline: Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents.diarylmethane
cinacalcet hydrochloridecinacalcet hydrochloride : A hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride.

Cinacalcet Hydrochloride: A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.
hydrochloridecalcimimetic;
P450 inhibitor
cinacalcetcinacalcet : A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.(trifluoromethyl)benzenes;
naphthalenes;
secondary amino compound
calcimimetic;
P450 inhibitor
nps-568N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine: NPS-568 is the ((R), HCl salt)-isomer; calcimimetic compound and calcium-sensing receptor agonist
nps-568
nps2143
ronacaleretronacaleret: a calcium-sensing receptor antagonist; structure in first source
azd7687AZD7687: structure in first source
pf-04620110PF-04620110: a DGAT1 inhibitor; structure in first source
pf-06424439PF-06424439: an inhibitor of diacylglycerol acyltransferase 2; structure in first source