Compounds > jatrophone
Page last updated: 2024-12-11

jatrophone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

jatrophone: RN refers to (2R-(2R*,3aR*,9E,12Z))-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6325446
CHEMBL ID2402276
CHEBI ID6086
MeSH IDM0048912

Synonyms (20)

Synonym
jatropha principle
nsc-135037
jatrophon
29444-03-9
jatrophone
C09120
CHEMBL2402276
chebi:6086 ,
nsc 135037
3a,6-epoxy-3ah-cyclopentacyclododecene-4,11-dione, 2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-, (2r-(2r*,3ar*,9e,12z))-
3abeta,6-epoxy-3ah-cyclopentacyclododecin-4,11-dione, 2,3,7,8-tetrahydro-2alpha,5,8,8,12-pentamethyl-, (+)-
2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-3alpha, 6-epoxy-3alphah-cyclopentacyclododecin-4,11-dione
3a,6-epoxy-3ah-cyclopentacyclododecene-4,11-dione, 2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-, [2r-(2r*,3ar*,9e,12z)]-
Q27107043
(+)-jatrophone
(2r,3ar,9e,12z)-2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-3a,6-epoxy-3ah-cyclopentacyclododecene-4,11-dione
3a,6-epoxy-3ah-cyclopentacyclododecene-4,11-dione, 2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-, (2r,3ar,9e,12z)-
R6ZN436TPE
3abeta,6-epoxy-3ah-cyclopentacyclododecene-4,11-dione, 2,3,7,8-tetrahydro-2alpha,5,8,8,12-pentamethyl-, (+)-
jatrophone, (+)-

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Jatrophone treatment significantly alleviated RSV mediated overproduction of IL-6/-8 and suppressed ROS generation in the cells."( Anti-viral activity of jatrophone against RSV-induced respiratory infection via increase in interferon-γ generating dendritic cells.
Li, K; Xu, Y; Yue, W, 2020)		1.59
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oxolanesAny oxacycle having an oxolane (tetrahydrofuran) skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (58)

Assay IDTitleYearJournalArticle
AID1538592Induction of apoptosis in human KOPN8 cells assessed as increase in cleaved caspase 7 level by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758307Half life in human plasma2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538639Upregulation of Trx expression in human KOPN8 at 10 uM after 3 to 6 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538593Induction of apoptosis in human KOPN8 cells assessed as increase in cleaved PARP 1 level by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758308Half life in mouse plasma2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538570Antiproliferative activity against human UOCB1 cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538610Induction of mitochondrial membrane potential loss in human KOPN8 cells at 4 uM after 24 hrs by TMRM staining based flow cytometric analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538578Cytotoxicity against human PBMC cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538599Induction of apoptosis in human MCF7 cells assessed as increase in cleaved PARP 1 level at 1 to 10 uM after 3 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538573Antiproliferative activity against human U2OS cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538595Induction of apoptosis in human MCF7 cells assessed as increase in cleaved PARP 1 level by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538594Induction of apoptosis in human MCF7 cells assessed as increase in cleaved caspase 7 level by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538623Cytotoxicity against human HMEC cells assessed as cell detachment2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538637Upregulation of Trx level in human KOPN8 at 1 uM after 3 to 6 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538568Antiproliferative activity against human KOPN8 cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758304Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in O-positive erythrocytes assessed as parasite growth inhibition after 72 hrs by DNA staining-based assay2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1385616Growth inhibition of human LoVo cells after 48 hrs by CCK-8 assay2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells.
AID1538571Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538618Induction of ROS generation in human MCF7 cells at 30 uM incubated for 1 hr in presence of NAC by CellROX green reagent based fluorescence assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758300Cytotoxicity against human BJ cells after 72 hrs by celltiter-glo assay2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID758302Cytotoxicity against human Raji cells after 72 hrs by celltiter-glo assay2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538620Induction of ROS generation in human U2OS cells at 30 uM incubated for 1 hr in presence of NAC by CellROX green reagent based fluorescence assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538613Induction of mitochondrial membrane potential loss in human KOPN8 cells at 30 uM by TMRM staining based flow cytometric analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538579Cytotoxicity against human HMEC cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538638Upregulation of Trx level in human MCF7 at 1 uM after 3 to 6 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538572Antiproliferative activity against human Raji cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538566Antiproliferative activity against mouse B-ALL cells harboring Bax/Bak double knockout mutant assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538565Antiproliferative activity against mouse B-ALL cells expressing wild type BCR-ABL assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538569Antiproliferative activity against human SEM cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538577Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538575Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability at 0.1 to 250 uM after 48 hrs by propidium iodide staining based fluorescence assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758313Efflux ratio of permeability in human Caco2 cells2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538591Cytotoxicity against human KOPN8 cells assessed as cell viability at 0.75 to 100 uM after 72 hrs in presence of pan caspase inhibitor, Z-VAD-FMK by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538644Upregulation of Trx expression in human MCF7 at 1 uM after 24 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538576Antiproliferative activity against human SUM149 cells assessed as reduction in cell viability at 0.1 to 250 uM after 48 hrs by propidium iodide staining based fluorescence assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538612Induction of mitochondrial membrane potential loss in human MCF7 cells at 4 uM after 24 to 48 hrs by TMRM staining based flow cytometric analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758312Permeability of the compound by PAMPA2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID758306Plasma protein binding in mouse2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538643Upregulation of Trx expression in human KOPN8 at 1 uM after 24 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758303Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in O-positive erythrocytes assessed as parasite growth inhibition after 72 hrs by DNA staining-based assay2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID758305Plasma protein binding in human2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID758309Half life in mouse liver microsomes2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538601Induction of apoptosis in human MCF7 cells assessed as decrease in caspase 3/7 level after 3 to 24 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538642Induction of cell death in human MCF7 cells at 10 uM after 24 hrs2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538598Induction of apoptosis in human KOPN8 cells assessed as increase in cleaved PARP 1 level at 1 to 10 uM after 3 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538641Induction of cell death in human KOPN8 cells at 4 to 10 uM after 24 hrs2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538600Induction of apoptosis in human KOPN8 cells assessed as decrease in caspase 3/7 level after 3 to 24 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758299Cytotoxicity against HEK293 cells after 72 hrs by celltiter-glo assay2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1538634Induction of mito-phagy in human U2OS cells transfected with mKeima-Red-Mito-7 at 1.25 to 2.5 uM incubated for 8 hrs by confocal scanning microscopic method2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538614Induction of ROS generation in human MCF7 cells at 30 uM incubated for 1 hr by CellROX green reagent based fluorescence assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538574Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538567Antiproliferative activity against human SUP-B15 cells assessed as reduction in cell viability at 0.1 to 250 uM by CellTiter-Glo assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID1538640Upregulation of Trx expression in human MCF7 at 10 uM after 3 to 6 hrs by Western blot analysis2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758310Half life in human liver microsomes2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID758301Cytotoxicity against human HepG2 cells after 72 hrs by celltiter-glo assay2013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
AID1385615Growth inhibition of human RKO cells after 48 hrs by CCK-8 assay2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells.
AID1538616Induction of ROS generation in human U2OS cells at 30 uM incubated for 1 hr by CellROX green reagent based fluorescence assay2019Journal of natural products, 05-24, Volume: 82, Issue:5
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
AID758311Solubility of the compound at pH 3 to 72013European journal of medicinal chemistry, Jul, Volume: 65Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (18.18)18.7374
1990's6 (27.27)18.2507
2000's5 (22.73)29.6817
2010's6 (27.27)24.3611
2020's1 (4.55)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.82 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		2.1110pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
bay-k-8644
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.. Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644. methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.		1.9710(trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester
caffeine
[no description available]		1.9810purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.. carbonyl cyanide p-trifluoromethoxyphenylhydrazone : A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.		2.2110aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.1710nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
1-(5-isoquinolinesulfonyl)-2-methylpiperazine
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.. 1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.		1.9810isoquinolines;
N-sulfonylpiperazine		EC 2.7.11.13 (protein kinase C) inhibitor
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.21101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
potassium chloride
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.		2.6730inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
syringaldehyde
syringaldehyde: isolated from nonfermented fiber fractions of oat hulls and cottonseed hulls. syringaldehyde : A hydroxybenzaldehyde that is 4-hydroxybenzaldehyde substituted by methoxy groups at positions 3 and 5. Isolated from Pisonia aculeata and Panax japonicus var. major, it exhibits hypoglycemic activity.		2.0310dimethoxybenzene;
hydroxybenzaldehyde		hypoglycemic agent;
plant metabolite
oleanolic acid
[no description available]		2.0310hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.3920acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.0310benzenes;
phenyl acetates
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.0310glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
staurosporine
[no description available]		2.2110indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
beta-amyrin
beta-amyrin: alpha-amyrin is also available; a 5 ring triterpene derived from oleanane that differs from alpha-amyrin in having the 29-carbon at the 20 position; RN given refers to (3 beta)-isomer. beta-amyrin : A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.		2.0310pentacyclic triterpenoid;
secondary alcohol		Aspergillus metabolite;
plant metabolite
acetyl aleuritolic acid
acetyl aleuritolic acid : A pentacyclic triterpenoid isolated from the leaves of Garcia parviflora.		2.0810acetate ester;
monocarboxylic acid;
pentacyclic triterpenoid		antineoplastic agent;
plant metabolite
oxytocin
Oxytocin: A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.. oxytocin : A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.		1.9710heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
ferruginol
ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.		7.1710abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols		antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent
naringin
[no description available]		2.0310(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
disaccharide derivative;
neohesperidoside		anti-inflammatory agent;
antineoplastic agent;
metabolite
euscaphic acid
euscaphic acid: isolated from medicinal plant, Euscaphis japonica Pax.; structure; RN given refers to 2alpha,3alpha-isomer. euscaphic acid : A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata.		2.0310hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triol		plant metabolite
drimanial
drimanial: isolated from the bark of Drimys wintery (Winteraceae); structure in first source		2.0310
sesquiterpenes
[no description available]		2.0310
scopoletin
[no description available]		2.0310hydroxycoumarinplant growth regulator;
plant metabolite
genistein
[no description available]		2.03107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
staurosporine
staurosporinium : Conjugate acid of staurosporine.		1.9810ammonium ion derivative
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.2110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.2110
Infections, Respiratory Syncytial Virus
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma.		02.2510
Pneumonia
Infection of the lung often accompanied by inflammation.		02.2510
Respiratory Syncytial Virus Infections
Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.		02.2510
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.1510
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.1510
Acute Confusional Senile Dementia
[description not available]		02.1710
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.1710
Mouth Diseases
Diseases involving the MOUTH.		02.1110
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.3920
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9810