acetyl aleuritolic acid : A pentacyclic triterpenoid isolated from the leaves of Garcia parviflora. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Garcia | genus | [no description available] | Euphorbiaceae | The spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 161616 |
| CHEMBL ID | 439422 |
| CHEBI ID | 70418 |
| Synonym |
|---|
| acetyl aleuritolic acid |
| hexadecnoic acid (acetyloxy) dihydroxy- |
| maprounic acid acetate |
| CHEMBL439422 |
| 3-acetylaleuritolic acid |
| chebi:70418 , |
| (4as,6br,8ar,10s,12ar,12br,14as,14bs)-10-(acetyloxy)-2,2,6b,9,9,12a,14a-heptamethyl-1,3,4,5,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-octadecahydropicene-4a(2h)-carboxylic acid |
| (4as,6ar,6br,8ar,10s,12ar,14as,14bs)-10-acetyloxy-2,2,6b,9,9,12a,14a-heptamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a-carboxylic acid |
| aleuritolic acid, acetyl- |
| nsc 266221 |
| hexadecanoic acid, (acetyloxy)dihydroxy-, (r*,s*)-(+-)- |
| d-friedoolean-14-en-28-oic acid, 3-(acetyloxy)-, (3beta)- |
| 3beta-acetoxyfriedoolean-14-ene-28-oic acid |
| bdbm50478510 |
| Q27138756 |
| (4as,6br,8ar,10s,12ar,12br,14as,14bs)-10-acetoxy-2,2,6b,9,9,12a,14a-heptamethyl-1,3,4,5,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-octadecahydropicene-4a(2h)-carboxylic acid |
| AKOS040746500 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| pentacyclic triterpenoid | |
| acetate ester | Any carboxylic ester where the carboxylic acid component is acetic acid. |
| monocarboxylic acid | An oxoacid containing a single carboxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 (µMol) | 136.0000 | 0.0001 | 1.0768 | 10.0000 | AID332420 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID327685 | Cytotoxicity against human NCI-H187 cells at 10 ug/mL | 2008 | Journal of natural products, Feb, Volume: 71, Issue:2 | Seco-terpenoids and other constituents from Elateriospermum tapos. |
| AID1387692 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay | 2018 | Journal of natural products, 10-26, Volume: 81, Issue:10 | Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production. |
| AID549991 | Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Triterpenes from Garcia parviflora. Cytotoxic evaluation of natural and semisynthetic friedelanes. |
| AID549993 | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Triterpenes from Garcia parviflora. Cytotoxic evaluation of natural and semisynthetic friedelanes. |
| AID549994 | Cytotoxicity against human SK-LU-1 cells after 48 hrs by sulforhodamine B assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Triterpenes from Garcia parviflora. Cytotoxic evaluation of natural and semisynthetic friedelanes. |
| AID549995 | Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Triterpenes from Garcia parviflora. Cytotoxic evaluation of natural and semisynthetic friedelanes. |
| AID327686 | Cytotoxicity against human breast cancer cells at 10 ug/mL | 2008 | Journal of natural products, Feb, Volume: 71, Issue:2 | Seco-terpenoids and other constituents from Elateriospermum tapos. |
| AID758304 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in O-positive erythrocytes assessed as parasite growth inhibition after 72 hrs by DNA staining-based assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. |
| AID758300 | Cytotoxicity against human BJ cells after 72 hrs by celltiter-glo assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. |
| AID332421 | Inhibition of HIV2 reverse transcriptase | 1994 | Journal of natural products, Mar, Volume: 57, Issue:3 | Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase. |
| AID1387693 | Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability at 1 to 100 uM after 24 hrs by MTT assay | 2018 | Journal of natural products, 10-26, Volume: 81, Issue:10 | Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production. |
| AID758301 | Cytotoxicity against human HepG2 cells after 72 hrs by celltiter-glo assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. |
| AID758302 | Cytotoxicity against human Raji cells after 72 hrs by celltiter-glo assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. |
| AID758303 | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in O-positive erythrocytes assessed as parasite growth inhibition after 72 hrs by DNA staining-based assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. |
| AID549992 | Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Triterpenes from Garcia parviflora. Cytotoxic evaluation of natural and semisynthetic friedelanes. |
| AID332420 | Inhibition of HIV1 reverse transcriptase | 1994 | Journal of natural products, Mar, Volume: 57, Issue:3 | Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase. |
| AID758299 | Cytotoxicity against HEK293 cells after 72 hrs by celltiter-glo assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.87) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||