adarotene has been researched along with Leukemia--Myeloid--Acute* in 2 studies
1 review(s) available for adarotene and Leukemia--Myeloid--Acute
| Article | Year |
|---|---|
Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926.
ST1926 is a novel related adamantyl retinoid endowed with potent antiproliferative and apoptogenic activity. The drug induced an early G1/S cell cycle arrest which was associated with a typical DNA damage response including modulation of genes involved in cell cycle regulation and DNA repair. The evidence of the drug ability to induce a significant extent of DNA strand breaks after short-term exposure is consistent with the cellular response. ST1926 is active by oral administration both on hematological and on solid tumors. The more marked antitumor effect showed by ST1926 in immuno-competent mice rather than in tumor xenografts suggests a contribution of indirect host-mediated antitumor effects in addition to a direct antiproliferative activity against tumor cells. Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cinnamates; Disease Models, Animal; Humans; Leukemia, Myeloid, Acute; Mice; Neoplasms; Sensitivity and Specificity; Treatment Outcome; Tumor Cells, Cultured | 2004 |
1 other study(ies) available for adarotene and Leukemia--Myeloid--Acute
| Article | Year |
|---|---|
Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.
(E)-4-[3'-(1-Adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell cycle arrest and apoptosis of cancer cells. Because its pharmacologic properties-solubility, bioavailability, and toxicity-required improvement for translation, structural modifications were made by introducing nitrogen atoms into the cinnamyl ring and replacing its E-double bond with XCH(2) (X = O, N, and S) with the objective of enhancing these properties without impacting apoptosis-inducing activity. Analogues having nitrogen atoms in heterocyclic rings corresponding to the cinnamyl phenyl ring displayed equal or higher biological activities. The pyrimidine and pyridine analogues were more soluble in both phosphate-buffered saline and water. While the 2,5-disubstituted pyridine analogue was the most potent inducer of KG-1 acute myeloid leukemia cell apoptosis, on the basis of apoptotic activity in KG-1 cells and solubility, the 2,5-disubstituted pyrimidine proved to be the more promising candidate for treatment of acute myeloid leukemia. Topics: Acrylates; Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cinnamates; Drug Design; Humans; Leukemia, Myeloid, Acute; Ligands; Mice; Orphan Nuclear Receptors | 2011 |