adarotene and Melanoma

adarotene has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for adarotene and Melanoma

Article	Year
A novel atypical retinoid endowed with proapoptotic and antitumor activity. Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6 The novel atypical retinoid E-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926, 4) exhibited a potent antiproliferative activity on a large panel of human tumor cells. Despite almost complete loss of ability to activate RARs, the compound was an effective apoptosis inducer and surprisingly produced DNA damage, that likely contributes to the proapoptotic activity. Following oral administration, 4 was well tolerated and caused tumor growth inhibition in the ovarian carcinoma, A2780/DX, and in the human melanoma, MeWo, growing in nude mice, thus supporting the therapeutic interest of the novel agent. Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cinnamates; DNA Damage; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Protein Isoforms; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured	2003

Article

Year

A novel atypical retinoid endowed with proapoptotic and antitumor activity.

Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

The novel atypical retinoid E-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926, 4) exhibited a potent antiproliferative activity on a large panel of human tumor cells. Despite almost complete loss of ability to activate RARs, the compound was an effective apoptosis inducer and surprisingly produced DNA damage, that likely contributes to the proapoptotic activity. Following oral administration, 4 was well tolerated and caused tumor growth inhibition in the ovarian carcinoma, A2780/DX, and in the human melanoma, MeWo, growing in nude mice, thus supporting the therapeutic interest of the novel agent.

Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cinnamates; DNA Damage; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Protein Isoforms; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured

2003