Dual specificity protein phosphatase 22

A dual specificity protein phosphatase 22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRW4]

Synonyms

EC 3.1.3.16;
EC 3.1.3.48;
JNK-stimulatory phosphatase-1;
JSP-1;
Low molecular weight dual specificity phosphatase 2;
LMW-DSP2;
Mitogen-activated protein kinase phosphatase x;
MAP kinase phosphatase x;
MKP-x

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
illudalic acid	Homo sapiens (human)	IC50	100.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
non-membrane spanning protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48]
protein tyrosine/serine/threonine phosphatase activity	molecular function	Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]
myosin phosphatase activity	molecular function	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]
protein tyrosine kinase binding	molecular function	Binding to protein tyrosine kinase. [PMID:25499537]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
leading edge of lamellipodium	cellular component	That part of the lamellipodium which represents the distal part of the structure. [PMID:22339865]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
filamentous actin	cellular component	A two-stranded helical polymer of the protein actin. [GOC:mah]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
negative regulation of T cell mediated immunity	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. [GOC:add]
transforming growth factor beta receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]
negative regulation of cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
peptidyl-tyrosine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]
regulation of cell population proliferation	biological process	Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
positive regulation of JNK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
negative regulation of T cell receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]
negative regulation of T cell activation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. [GOC:ai]
negative regulation of focal adhesion assembly	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai]
cellular response to epidermal growth factor stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:mah]
negative regulation of non-membrane spanning protein tyrosine kinase activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
dephosphorylation	biological process	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]