Compounds > complestatin
Page last updated: 2024-11-12

complestatin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

complestatin: compound extracted from Streptomyces lavendulae mycelia; on acid hydrolysis yields D-4-hydroxyphenylglycine & D-3,5-dichloro-4-hydroxyphenylglycine & acidic chromophore; inhibits gp120-CD4 binding [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

isocomplestatin : A heterodetic cyclic peptide which is a atropisomer of complestatin. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

chloropeptin II : A heterodetic cyclic peptide consisting of N-acylated trytophan, 3,5-dichloro-4-hydroxyphenylglycine, 4-hydroxyphenylglycine, 3,5-dichloro-4-hydroxyphenylglycyl, tyrosine and 4-hydroxyphenylglycine residues joined in sequence and in which the side-chain of the central 4-hydroxyphenylglycine residue is attached to the side-chain of the tryptophan via a C3-C6 bond and to the side-chain of the tyrosine via an ether bond from C5. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID16134403
CHEMBL ID437996
CHEMBL ID506605
CHEBI ID66093
CHEBI ID65619
MeSH IDM0080789

Synonyms (11)

Synonym
sch-79235
wk-3419a
chloropeptin ii
complestatin
69598-75-0
isocomplestatin
bdbm50123449
chembl437996
chebi:66093 ,
CHEMBL506605
CHEBI:65619
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
anti-HIV-1 agentAn anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus.
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
HIV-1 integrase inhibitorAn inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (7)

ClassDescription
indolesAny compound containing an indole skeleton.
cyclic etherAny ether in which the oxygen atom forms part of a ring.
heterodetic cyclic peptideA heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
peptide antibioticA chemically diverse class of peptides that exhibit antimicrobial properties.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
heterodetic cyclic peptideA heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
cyclic etherAny ether in which the oxygen atom forms part of a ring.
organic heterobicyclic compound
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
T-cell surface glycoprotein CD4Homo sapiens (human)IC50 (µMol)0.13000.13000.13000.1300AID42787
Integrase Human immunodeficiency virus 1IC50 (µMol)1.64000.00051.544310.0000AID356722; AID356723; AID356724; AID356725; AID356726
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (33)

Processvia Protein(s)Taxonomy
maintenance of protein location in cellT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of protein phosphorylationT-cell surface glycoprotein CD4Homo sapiens (human)
adaptive immune responseT-cell surface glycoprotein CD4Homo sapiens (human)
immune responseT-cell surface glycoprotein CD4Homo sapiens (human)
cell adhesionT-cell surface glycoprotein CD4Homo sapiens (human)
signal transductionT-cell surface glycoprotein CD4Homo sapiens (human)
cell surface receptor signaling pathwayT-cell surface glycoprotein CD4Homo sapiens (human)
enzyme-linked receptor protein signaling pathwayT-cell surface glycoprotein CD4Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathwayT-cell surface glycoprotein CD4Homo sapiens (human)
calcium-mediated signalingT-cell surface glycoprotein CD4Homo sapiens (human)
T cell differentiationT-cell surface glycoprotein CD4Homo sapiens (human)
macrophage differentiationT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of interleukin-2 productionT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of kinase activityT-cell surface glycoprotein CD4Homo sapiens (human)
helper T cell enhancement of adaptive immune responseT-cell surface glycoprotein CD4Homo sapiens (human)
interleukin-15-mediated signaling pathwayT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of MAPK cascadeT-cell surface glycoprotein CD4Homo sapiens (human)
T cell selectionT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of monocyte differentiationT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of protein kinase activityT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of DNA-templated transcriptionT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of viral entry into host cellT-cell surface glycoprotein CD4Homo sapiens (human)
symbiont entry into host cellT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationT-cell surface glycoprotein CD4Homo sapiens (human)
defense response to Gram-negative bacteriumT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of calcium-mediated signalingT-cell surface glycoprotein CD4Homo sapiens (human)
regulation of T cell activationT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of T cell activationT-cell surface glycoprotein CD4Homo sapiens (human)
regulation of calcium ion transportT-cell surface glycoprotein CD4Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeT-cell surface glycoprotein CD4Homo sapiens (human)
cellular response to granulocyte macrophage colony-stimulating factor stimulusT-cell surface glycoprotein CD4Homo sapiens (human)
T cell activationT-cell surface glycoprotein CD4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (17)

Processvia Protein(s)Taxonomy
virus receptor activityT-cell surface glycoprotein CD4Homo sapiens (human)
transmembrane signaling receptor activityT-cell surface glycoprotein CD4Homo sapiens (human)
extracellular matrix structural constituentT-cell surface glycoprotein CD4Homo sapiens (human)
protein bindingT-cell surface glycoprotein CD4Homo sapiens (human)
zinc ion bindingT-cell surface glycoprotein CD4Homo sapiens (human)
lipid bindingT-cell surface glycoprotein CD4Homo sapiens (human)
coreceptor activityT-cell surface glycoprotein CD4Homo sapiens (human)
enzyme bindingT-cell surface glycoprotein CD4Homo sapiens (human)
protein kinase bindingT-cell surface glycoprotein CD4Homo sapiens (human)
MHC class II protein complex bindingT-cell surface glycoprotein CD4Homo sapiens (human)
signaling receptor activityT-cell surface glycoprotein CD4Homo sapiens (human)
interleukin-16 bindingT-cell surface glycoprotein CD4Homo sapiens (human)
interleukin-16 receptor activityT-cell surface glycoprotein CD4Homo sapiens (human)
MHC class II protein bindingT-cell surface glycoprotein CD4Homo sapiens (human)
identical protein bindingT-cell surface glycoprotein CD4Homo sapiens (human)
protein homodimerization activityT-cell surface glycoprotein CD4Homo sapiens (human)
protein tyrosine kinase bindingT-cell surface glycoprotein CD4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
early endosomeT-cell surface glycoprotein CD4Homo sapiens (human)
endoplasmic reticulum lumenT-cell surface glycoprotein CD4Homo sapiens (human)
endoplasmic reticulum membraneT-cell surface glycoprotein CD4Homo sapiens (human)
plasma membraneT-cell surface glycoprotein CD4Homo sapiens (human)
external side of plasma membraneT-cell surface glycoprotein CD4Homo sapiens (human)
clathrin-coated endocytic vesicle membraneT-cell surface glycoprotein CD4Homo sapiens (human)
membrane raftT-cell surface glycoprotein CD4Homo sapiens (human)
T cell receptor complexT-cell surface glycoprotein CD4Homo sapiens (human)
membrane raftT-cell surface glycoprotein CD4Homo sapiens (human)
external side of plasma membraneT-cell surface glycoprotein CD4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID356723Inhibition of HIV1 integrase strand transfer activity2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356725Inhibition of disintegration activity of HIV1 integrase catalytic core domain (50 to 212)2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID42787Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uM2003Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3
Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.
AID356724Inhibition of disintegration activity of HIV1 intact integrase2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356730Antiviral activity against HIV PIC2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID44673Inhibition of CD28-CD80 interaction in the presence of fetal bovine serum (FBS)2003Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3
Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.
AID356731Antiviral activity against HIV2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356732Inhibition of HIV1 recombinant gp120/CD4 interaction by ELISA2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356722Inhibition of HIV1 integrase 3' processing/strand transfer coupled activity2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356728Antiviral activity against Simian immunodeficiency virus2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356727Antiviral activity against Feline immunodeficiency virus2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356721Antiviral activity against HIV1 assessed as inhibition of viral spread in infected cells2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID356729Antiviral activity against Avian myeloblastosis virus2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
AID44672Inhibition of CD28-CD80 interaction in the absence of fetal bovine serum (FBS)2003Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3
Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.
AID356726Inhibition of integration activity of HIV1 intact integrase2001Journal of natural products, Jul, Volume: 64, Issue:7
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (8.57)18.7374
1990's7 (20.00)18.2507
2000's14 (40.00)29.6817
2010's9 (25.71)24.3611
2020's2 (5.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.55 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.55)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.86%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other34 (97.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		2.0710aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
aminocaproic acid
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.. 6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.		2.0210amino acid zwitterion;
epsilon-amino acid;
omega-amino fatty acid		antifibrinolytic drug;
hematologic agent;
metabolite
indole
[no description available]		7.4620indole;
polycyclic heteroarene		Escherichia coli metabolite
naphthalene
[no description available]		2.0710naphthalenes;
ortho-fused bicyclic arene		apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.2510monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
phenol
[no description available]		2.0710phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.		2.0110non-proteinogenic alpha-amino acid
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		1.9910aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
2,3,4,6-tetrachlorophenol
2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.		6.01350tetrachlorophenolxenobiotic metabolite
quinoxalines
quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.		2.0110mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
kainic acid
Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.		2.4120dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		210glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
streptomycin
[no description available]		1.9810antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.4520metal allergen;
nickel group element atom;
platinum group metal atom
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		2.0510diatomic bromine
alkenes
[no description available]		2.0510
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		1.9910azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
phorbol 12,13-dibutyrate
Phorbol 12,13-Dibutyrate: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.		2.0110butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone
glycidyl nitrate
glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.		2.2510
combretastatin
combretastatin: cytotoxic principle from South African tree COMBRETUM caffrum; structure given in first source; acts at COLCHICINE site of TUBULIN		2.0510
erianin
Erianin: from Dendrobium chrysotoxum; structure in first source		2.0710
fibrin
Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.		7.420peptide
chalcone
trans-chalcone : The trans-isomer of chalcone.		2.1110chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.0510stilbene
fg 9041
FG 9041: structure given in first source		2.0110quinoxaline derivative
alpha-chymotrypsin
Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.		1.9710
fosbretabulin
fosbretabulin: a microtubule destabilizing agent isolated from Combretum caffrum; structure in first source		2.0510
staurosporine
staurosporinium : Conjugate acid of staurosporine.		2.0110ammonium ion derivative
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0210
neuroprotectin a
neuroprotectin A: Isolated from Streptomyces sp. Q27107; structure in first source. complestatin A : A heterodetic cyclic peptide that is chloropeptin II in which the indole moiety is oxidised to the corresponding 2-oxindole. It is a HIV-1 integrase inhibitor isolated from Streptomyces.		2.4420cyclic ether;
heterodetic cyclic peptide;
indoles;
organochlorine compound;
polyphenol		HIV-1 integrase inhibitor;
metabolite
chloroeremomycin
chloroeremomycin: structure given in first source. chloroeremomycin : A complex glycopeptide antibiotic that is isolated from Amycolatopsis orientalis.. chloroeremomycin(2+) : An organic cation obtained by deprotonation of the carboxy group and protonation of the three amino functions of chloroeremomycin; major species at pH 7.3.		210organic cation
chloropeptin i
chloropeptin I: inhibitor of gp120-CD4 binding; isolated from Streptomyces; structure in first source. chloropeptin I : A heterodetic cyclic peptide consisting of N-acylated trytophan, 3,5-dichloro-4-hydroxyphenylglycine, 4-hydroxyphenylglycine, 3,5-dichloro-4-hydroxyphenylglycyl, tyrosine and 4-hydroxyphenylglycine residues joined in sequence and in which the side-chain of the central 4-hydroxyphenylglycine residue is attached to the side-chain of the tryptophan via a C3-C7 bond and to the side-chain of the tyrosine via an ether bond from C5. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity.		3.72100
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Infections, Staphylococcal
[description not available]		02.5720
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.5720
Extravascular Hemolysis
[description not available]		02.3720
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.3720
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		01.9810
Cerebral Ischemia
[description not available]		0210
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.		0210
Anaphylactic Reaction
[description not available]		01.9710
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		01.9710