| Assay ID | Title | Year | Journal | Article |
|---|
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID108985 | Ratio between EC50 of compound and glutamate measured against Metabotropic glutamate receptor 2 | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID224980 | Stimulation of [3H]IP (tritiated inositol monophosphate) formation in cross-chopped slices of the neonata rat cerebral cortex. | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID109341 | Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4) | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID221527 | Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor | 1999 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 9, Issue:12
| 1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties. |
| AID92205 | Affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA in selective radioligand binding assay | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID107093 | Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6). | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID246705 | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4. |
| AID144463 | Affinity value against N-methyl-D-aspartate (NMDA) receptor using [3H]-CGS- 19755 in glutamate radioligand binding assay. | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID221665 | Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptor | 1999 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 9, Issue:12
| 1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties. |
| AID108506 | Ratio between EC50 of compound and glutamate measured against metabotropic glutamate receptor 1 | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID108489 | Agonist potency against cloned human metabotropic glutamate receptor 1 | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID108978 | Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2 | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14
| Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. |
| AID75026 | Compound was tested for radioligand using Group II Metabotropic glutamate receptor in the rat brain | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| [3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors. |
| AID93555 | Affinity value against Ionotropic glutamate receptor kainate using [3H]-kainic acid in selective radioligand binding assay. | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID75021 | The effective concentration for 50% glutamate response was measured on Group II Metabotropic glutamate receptor | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity. |
| AID107274 | Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID75015 | The effective concentration for 50% glutamate response was measured on Group I Metabotropic glutamate receptor | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity. |
| AID107261 | Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7). | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID224058 | Augmentation of AMPA-induced excitation after Microelectrophoretic application to intact rat spinal neuron | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID108992 | Inhibitory concentration against Metabotropic glutamate receptor 2; No data | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14
| Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. |
| AID109172 | Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3 | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14
| Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. |
| AID109164 | Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3). | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID107243 | Effective concentration for agonistic activity at Metabotropic glutamate receptor 6; Not active | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14
| Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. |
| AID224976 | Dose dependent blocking of limbic seizures induced by compound 1 by systemically administrating intraperitoneally | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID109310 | Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 3; No data | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14
| Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. |
| AID108830 | Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2). | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID224978 | Inhibition of forskolin-stim cAMP formation in cross-chopped slices of the adult rat cerebral cortex. | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID107059 | Agonist potency against cloned metabotropic glutamate receptor 5 | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Ligands for glutamate receptors: design and therapeutic prospects. |
| AID108348 | In vitro ability to displace [3H]glutamate binding to metabotropic glutamate receptors in rat forebrain membranes | 1996 | Journal of medicinal chemistry, Jul-19, Volume: 39, Issue:15
| Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. |
| AID75025 | Compound was tested for radioligand using Group II Metabotropic glutamate receptor agonist | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| [3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors. |
| AID1346271 | Human mGlu2 receptor (Metabotropic glutamate receptors) | 1999 | Neuropharmacology, Oct, Volume: 38, Issue:10
| [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |