Compounds > variabilin
Page last updated: 2024-11-13

variabilin

Description

variabilin: an RGD-containing antagonist of glycoprotein IIb-IIIa from the hard tick, Dermacentor variabilis; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID54682873
CHEMBL ID464276
MeSH IDM0264054

Synonyms (8)

Synonym
variabilin
CHEMBL464276 ,
7e,12e,20z-variabilin
(7e,12e,20z,18s)-variabilin
2(5h)-furanone, 5-(13-(3-furanyl)-2,6,10-trimethyl-6,10-tridecadienylidene)-4-hydroxy-3-methyl-
nsc 227263
5-(13-(3-furanyl)-2,6,10-trimethyl-6,10-tridecadienylidene)-4-hydroxy-3-methyl-2(5h)-furanone
bdbm50232636
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Receptor-type tyrosine-protein phosphatase CHomo sapiens (human)IC50 (µMol)1.20000.30002.757110.0000AID1430419
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)IC50 (µMol)0.80000.70004.58049.4500AID1430418
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)1.50000.00053.49849.7600AID1430417
Dual specificity protein phosphatase 3Homo sapiens (human)IC50 (µMol)6.00004.00005.97508.5000AID1430420
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (122)

Processvia Protein(s)Taxonomy
MAPK cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
natural killer cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of T cell mediated cytotoxicityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of cytokine-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
hematopoietic progenitor cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of immunoglobulin productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of humoral immune response mediated by circulating immunoglobulinReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of protein kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of cell adhesion involved in substrate-bound cell migrationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
leukocyte cell-cell adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell surface receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
response to gamma radiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of gene expressionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
dephosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of B cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of protein autophosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of interleukin-8 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of interleukin-2 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of interleukin-2 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of tumor necrosis factor productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heterotypic cell-cell adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell activationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
gamma-delta T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of MAPK cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell cycle phase transitionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive thymic T cell selectionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative thymic T cell selectionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of gamma-delta T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of protein kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of receptor signaling pathway via JAK-STATReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
alpha-beta T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of alpha-beta T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of isotype switching to IgG isotypesReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
bone marrow developmentReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
stem cell developmentReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of phagocytosisReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of phagocytosisReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of calcium-mediated signalingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of T cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of antigen receptor-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
release of sequestered calcium ion into cytosolReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
defense response to virusReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of cell cycleReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of Fc receptor mediated stimulatory signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of protein tyrosine kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
extrinsic apoptotic signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of microglial cell activationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
response to aldosteroneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
DN2 thymocyte differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of hematopoietic stem cell migrationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of stem cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of transcription by RNA polymerase IITyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of cell population proliferationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of tumor necrosis factor-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of lipid storageTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
B cell differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
T cell differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
erythrocyte differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of tyrosine phosphorylation of STAT proteinTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
glucose homeostasisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of macrophage differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of gluconeogenesisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of inflammatory responseTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of chemotaxisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
regulation of type II interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of type II interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-6-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-2-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-4-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of macrophage colony-stimulating factor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of positive thymic T cell selectionTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
dephosphorylationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of cell migrationDual specificity protein phosphatase 3Homo sapiens (human)
peptidyl-tyrosine dephosphorylationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathwayDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of MAPK cascadeDual specificity protein phosphatase 3Homo sapiens (human)
positive regulation of mitotic cell cycleDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of JNK cascadeDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of T cell activationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of chemotaxisDual specificity protein phosphatase 3Homo sapiens (human)
regulation of focal adhesion assemblyDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeDual specificity protein phosphatase 3Homo sapiens (human)
cellular response to epidermal growth factor stimulusDual specificity protein phosphatase 3Homo sapiens (human)
positive regulation of focal adhesion disassemblyDual specificity protein phosphatase 3Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityDual specificity protein phosphatase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (27)

Processvia Protein(s)Taxonomy
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
signaling receptor bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heparin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein kinase bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
ankyrin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
spectrin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heparan sulfate proteoglycan bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
integrin bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
syntaxin bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
STAT family protein bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein bindingDual specificity protein phosphatase 3Homo sapiens (human)
cytoskeletal protein bindingDual specificity protein phosphatase 3Homo sapiens (human)
protein tyrosine/serine/threonine phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
myosin phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
receptor tyrosine kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
MAP kinase phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein tyrosine kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (26)

Processvia Protein(s)Taxonomy
plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
focal adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
external side of plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cytoplasmic side of plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell surfaceReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
secretory granule membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
blebReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membrane raftReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
synapseReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
extracellular exosomeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membrane microdomainReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
immunological synapseDual specificity protein phosphatase 3Homo sapiens (human)
nucleusDual specificity protein phosphatase 3Homo sapiens (human)
nucleoplasmDual specificity protein phosphatase 3Homo sapiens (human)
cytosolDual specificity protein phosphatase 3Homo sapiens (human)
cytosolDual specificity protein phosphatase 3Homo sapiens (human)
cytoplasmDual specificity protein phosphatase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID474942Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp assay2010Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.
AID1430425Inhibition of PTP1B in human HuH7 cells assessed as reduction in insulin-stimulated Akt phosphorylation at 50 uM preincubated for 2 hrs followed by insulin stimulation for 5 mins by Western blot method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID1430418Inhibition of full length recombinant N-terminal GST-tagged human TCPTP expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID1430424Selectivity ratio of IC50 for human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast to IC50 for recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID474945Agonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp assay2010Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.
AID1430421Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by WST1 assay2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID1430417Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID474949Antagonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx by whole cell patch clamp assay2010Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.
AID474948Antagonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx by whole cell patch clamp assay2010Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.
AID1430422Cytotoxicity against human EJ1 cells assessed as reduction in cell viability after 72 hrs by WST1 assay2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID1430423Selectivity ratio of IC50 for full length recombinant N-terminal GST-tagged human TCPTP expressed in Escherichia coli to IC50 for recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID1430419Inhibition of human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
AID1430420Inhibition of human VHR expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.16 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.17 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		2.0610metal allergen;
nickel group element atom		epitope;
micronutrient
stearic acid
octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.		7.2510long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite
oleanolic acid
[no description available]		2.1510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
3-hydroxyflavone
3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.		2.0610flavonols;
monohydroxyflavone
arginyl-glycyl-aspartic acid
arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system		1.9910oligopeptide
leukotriene b4
Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene B4 : A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.		1.9910dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
WIN 55212-2 : A organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group.		2.0510morpholines;
naphthyl ketone;
organic heterotricyclic compound;
synthetic cannabinoid		analgesic;
apoptosis inhibitor;
neuroprotective agent
hu 210
[no description available]		2.05101-benzopyran
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.2510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.2510
Anasarca
[description not available]		01.9910
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		01.9910
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