Compounds > u 93385
Page last updated: 2024-12-07

u 93385

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

U 93385: cis-isomer more active than trans-isomer; has good oral availability; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID132792
CHEMBL ID349003
SCHEMBL ID3375158
MeSH IDM0219601

Synonyms (15)

Synonym
(3ar,9bs)-3-propyl-2,3,3a,4,5,9b-hexahydro-1h-benzo[e]indole-9-carboxylic acid amide
bdbm50036470
2,3,3a,4,5,9b-hexahydro-3-propyl-1h-benz(e)indole-9-carboxamide
1h-benz(e)indole-9-carboxamide, 2,3,3a,4,5,9b-hexahydro-3-propyl-, (3ar-cis)-
147145-16-2
u-93385
u 93385
u93385
SCHEMBL3375158
pnu-93385
CHEMBL349003 ,
(3ar,9bs)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indole-9-carboxamide
cis-(3ar)-(-)-2,3,3a,4,5,9b-hexahydro-3-propyl-1h-benz[e]indole-9-carboxamide
3-propyl-2,3,3a,4,5,9b-hexahydro-1h-benzo[e]indole-9-carboximidic acid
DTXSID60933042

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" In contrast, cumulative dosing of U-93385E (0."( Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists.
Clement, ME; Escandon, NA; Harris, LT; McCall, RB, 1994)		0.29
" In contrast, cumulative dosing of U-93385E (0."( Rapid and long duration tolerance to the vagal bradycardic effects of 5-HT1A receptor agonists.
Clement, ME; Escandon, NA; Harris, LT; McCall, RB, 1996)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki0.01500.00010.532610.0000AID3801
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.00190.00010.739610.0000AID4099
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki1.62900.00000.437510.0000AID65714
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
behavioral fear response5-hydroxytryptamine receptor 1AHomo sapiens (human)
G protein-coupled receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
adenylate cyclase-inhibiting serotonin receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
gamma-aminobutyric acid signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
positive regulation of cell population proliferation5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of serotonin secretion5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of vasoconstriction5-hydroxytryptamine receptor 1AHomo sapiens (human)
exploration behavior5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of dopamine metabolic process5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin metabolic process5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of hormone secretion5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of behavior5-hydroxytryptamine receptor 1AHomo sapiens (human)
chemical synaptic transmission5-hydroxytryptamine receptor 1AHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger5-hydroxytryptamine receptor 1AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
G protein-coupled serotonin receptor activity5-hydroxytryptamine receptor 1AHomo sapiens (human)
protein binding5-hydroxytryptamine receptor 1AHomo sapiens (human)
receptor-receptor interaction5-hydroxytryptamine receptor 1AHomo sapiens (human)
neurotransmitter receptor activity5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin binding5-hydroxytryptamine receptor 1AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
plasma membrane5-hydroxytryptamine receptor 1AHomo sapiens (human)
synapse5-hydroxytryptamine receptor 1AHomo sapiens (human)
plasma membrane5-hydroxytryptamine receptor 1AHomo sapiens (human)
dendrite5-hydroxytryptamine receptor 1AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (47)

Assay IDTitleYearJournalArticle
AID3801Binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID177865Inhibition of 5-HT1A cell firing in rats1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773985-HTP accumulation in limbic system of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID197251In vitro stability in rat hepatocytes relative to that of PNU-93385.2001Journal of medicinal chemistry, Dec-20, Volume: 44, Issue:26
Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans.
AID47980Inhibition of sympathetic nerve discharge (SND) in anesthetized cat1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID187074In vitro metabolic stability of the test compound was evaluated after incubation in the presence of freshly isolated rat hepatocytes1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID1773875-HTP accumulation in corpus striatum of reserpinized rats following peroral administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID176530DOPA accumulation in hemispheres of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID124314Swimming activity of the treated mice/control mice at 1.2 umol/kg, sc1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID184743DOPA accumulation in corpus striatum of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID65714Displacement of [3H]U-86170 from Dopamine receptor D21995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID1773935-HTP accumulation in hemispheres of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID124319Swimming activity of the treated mice/control mice at 39 umol/kg, sc1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID176528DOPA accumulation in corpus striatum of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID4099In vitro displacement of radioactively labeled ligand [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor site in CHO cells1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID184882DOPA accumulation in limbic system of reserpinized rats following peroral administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID177648Effect on hypothermia in rats following peroral administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773945-HTP accumulation in hemispheres of reserpinized rats following subcutaneous administration.1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773975-HTP accumulation in limbic system of reserpinized rats following subcutaneous administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773915-HTP accumulation in hemispheres of reserpinized rats following peroral administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID194002postsynaptic effects was assessed by the increase in the locomotor activity (reversal of reserpine induced hypokinesia) during a 30 min period after subcutaneous administration using photocell motility meters at dose of 12.5 (uM /kg)1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID177171In vivo effects on DA (dopamine) synthesis in corps striatum was reported after subcutaneous administration to reserpinized rats; inactive at a dose of 501995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID184883DOPA accumulation in limbic system of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID184881DOPA accumulation in hemispheres of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID190912Compound was tested for gross behavioral response in rats; full-blown 5-HT syndrome1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID181256in vivo effects on DA (dopamine) synthesis in cortex was reported after subcutaneous administration to reserpinized rats; inactive at a dose of 501995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID1773995-HTP accumulation in limbic system was determined in vivo1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
AID189827In vivo motor activity at 12.5 umol/kg (po) in male rats expressed as accumulated counts/30 min (p < 0.001)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID49590Maximum decrease in sympathetic nerve discharge in anesthetized cat.1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID184742DOPA accumulation in corpus striatum of reserpinized rats following peroral administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID50207Percent arterial blood pressure at sympathetic nerve discharge in anesthetized cat1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773895-HTP accumulation in corpus striatum of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID176533DOPA accumulation in limbic system of reserpinized rats following subcutaneous administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID189828In vivo motor activity at 12.5 umol/kg (sc) in male rats expressed as accumulated counts/30 min (p < 0.001)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773905-HTP accumulation in corpus striatum of reserpinized rats following subcutaneous administration.1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID49588Maximum decrease in blood pressure observed following 1 mg/kg dose in anesthetized cat1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID184880DOPA accumulation in hemispheres of reserpinized rats following peroral administration at highest dose tested (50 umol/kg); Inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID124316Swimming activity of the treated mice/control mice at 12 umol/kg, sc (p < 0.001)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID24364Half-life time in rats1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID190914Compound was tested for gross behavioral response in rats; partial 5-HT syndrome1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID124445Swimming activity of the treated mice/control mice at 39 umol/kg, sc (p < 0.05)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID189831In vivo motor activity at 50 umol/kg (sc) in male rats expressed as accumulated counts/30 min1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID124315Swimming activity of the treated mice/control mice at 12 umol/kg, sc1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID177649Effect on hypothermia in rats following subcutaneous administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID196144Oral availability obtained from blood plasma levels of the parent compound following 5 umol /kg intravenous and 40 umol /kg peroral administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID124318Swimming activity of the treated mice/control mice at 3.9 umol/kg, sc (p < 0.001)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
AID1773965-HTP accumulation in limbic system of reserpinized rats following peroral administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
8-hydroxy-2-(di-n-propylamino)tetralin
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.. 8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively		2.6730phenols;
tertiary amino compound;
tetralins		serotonergic antagonist
buspirone
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.. buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.		1.9810azaspiro compound;
N-alkylpiperazine;
N-arylpiperazine;
organic heteropolycyclic compound;
piperidones;
pyrimidines		anxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist
u 99194
[no description available]		210indanes
gepirone
gepirone: RN given refers to parent cpd; structure given in first source		1.9810N-arylpiperazine
flesinoxan
[no description available]		1.9910
4-hydroxy-2-(di-n-propylamino)indan
4-hydroxy-2-(di-n-propylamino)indan: RN & structure given in first source; RN refers to (R)-isomer		210
ConditionIndicatedRelationship StrengthStudiesTrials