| Assay ID | Title | Year | Journal | Article |
|---|
| AID204462 | Binding affinity for sigma receptor of guinea pig whole brain using [3H]-SKF- 100047 radioligand | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3
| Piperidinyltetralin sigma ligands. |
| AID1845725 | Selectivity ratio of Ki for rat liver Sigma2 receptor to Ki for Guinea pig brain Sigma1 receptor | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Spirocyclic Scaffolds in Medicinal Chemistry. |
| AID225350 | Antimescaline activity in the mouse (administered po) | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3
| Piperidinyltetralin sigma ligands. |
| AID1393295 | Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. |
| AID225346 | Ability to block the aggressive behavior caused by prolonged isolation in mouse (administered po) | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3
| Piperidinyltetralin sigma ligands. |
| AID204762 | Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. |
| AID1845723 | Binding affinity to Guinea pig brain Sigma1 receptor assessed as inhibition constant | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Spirocyclic Scaffolds in Medicinal Chemistry. |
| AID204772 | Binding affinity towards sigma receptor binding site 2 using [3H]DTG of whole rat brain homogenates except cerebellum | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID204771 | Binding affinity towards Sigma receptor type 2 in whole rat brain homogenates except cerebellum using radioligand ([3H]DTG) binding assay. | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. |
| AID64613 | Binding affinity towards Dopamine receptor D2 binding site using [3H]spiroperidol. | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID176971 | In vivo antagonism of compound determined by the ability to inhibit 5-HTP-induced head twitch in rat (administered po) | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3
| Piperidinyltetralin sigma ligands. |
| AID62740 | Binding affinity for dopamine D2 receptor using [3H]spiperone in guinea pig striatum | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3
| Piperidinyltetralin sigma ligands. |
| AID204764 | Ratio of the binding affinities against Sigma receptor type 1 and Sigma receptor type 2 | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. |
| AID5011 | Binding affinity for serotonin 5-hydroxytryptamine 2 receptor using [3H]ketanserin in guinea pig frontal cortex | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3
| Piperidinyltetralin sigma ligands. |
| AID4136 | Binding affinity towards 5-hydroxytryptamine 1A receptor binding site using [3H]8-OH-DPAT. | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID204763 | Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID1845724 | Binding affinity to rat liver Sigma2 receptor assessed as inhibition constant | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Spirocyclic Scaffolds in Medicinal Chemistry. |
| AID1393294 | Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. |
| AID230925 | Binding affinities for sigma-1 and sigma 2 receptors, ratio of IC50 | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID37007 | Binding affinity towards Alpha-1 adrenergic receptor binding site using [3H]prazosin. | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID5491 | Binding affinity towards 5-hydroxytryptamine 2A receptor binding site using [3H]ketanserin. | 1995 | Journal of medicinal chemistry, May-26, Volume: 38, Issue:11
| Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |