| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID18171 | Bioavailability in rat plasma following iv/po dose | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID10724 | Area under the curve after intravenous administration at a dose of 4 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID49574 | Maximum decrease in sympathetic nerve discharge(SND) observed at 1 mg/kg dose in cat | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID176620 | Ratio of the 5HTP-accumulation decrease in limbic regions after sc to that of po administration at 10 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID197513 | Log concentration to inhibit 5-HTP accumulation was determined in rat brain hemispheres | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID3471 | Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of bovine hippocampus. | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID180730 | The concentration yielding a half maximal decrease of the DOPA was determined in rat brain hemispheres; Inactive at 12.5 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID197515 | Log concentration to inhibit 5-HTP accumulation was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID55590 | Dose to reduce neuronal firing against DA cells in rats (iv) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID179995 | The Compound was tested in vivo for DOPA accumulation in hemispheres (cortex) against reserpine-pretreated rats; I= inactive at the highest dose tested (12.5). | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID229085 | Ratio of the 5-HTP accumulation decrease in limbic regions after oral and subcutaneous administration in rat. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID180739 | The concentration yielding a half maximal decrease of the DOPA was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID25181 | Half life in plasma after administration of 4 umol/kg dose intravenously | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID18624 | Bioavailability in rat (dose 10 uM/kg) | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID113319 | Dose required to obtain hypothermic effect in mice following subcutaneous administration | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID197514 | Log concentration to inhibit 5-HTP accumulation was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID178897 | In vivo for 5-HTP accumulation in limbic system against reserpine-pretreated rats. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID124449 | Maximum obtainable hypothermic effect up to 30 mg/kg dose in mice expressed as temperature decrease in degree Centigrade | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID20965 | tmax in hours at a po dose of 10.0(pmol/g/h). | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID14064 | Maximum concentration in plasma after administration of 4 umol/kg dose intravenously | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID178892 | In vivo for 5-HTP accumulation in hemispheres (cortex) against reserpine-pretreated rats. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID24760 | Time taken to reach maximum concentration after administration of 10 umol/kg dose perorally | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID65911 | Displacement of the radioligand [3H]spiperone from D2 receptor | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID197517 | Log concentration to inhibit DOPA accumulation was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID180716 | The concentration yielding a half maximal decrease of the 5-HTP was determined in rat brain hemispheres. | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID169550 | Motor activity was measured by motility testing on injecting the compound subcutaneously into rats at the dose of 12.5 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID16504 | Cmax in minutes at a po dose of 10.0(pmol/g/h). | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID180725 | The concentration yielding a half maximal decrease of the 5-HTP was determined in rat limbic system. | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID180749 | The concentration yielding a half maximal decrease of the DOPA was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID14062 | Maximum concentration in plasma after administration of 10 umol/kg dose perorally | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID180005 | In vivo for DOPA accumulation in limbic system against reserpine-pretreated rats. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID63410 | Displacement of [3H]U-86170 from human D2-dopamine receptor expressed in CHO K1 cells | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID10939 | Bioavailability in male Sprague-Dawley rats, after the iv administration at a dose of 4.0(pmol/g/h) | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID20962 | tmax in hours at a iv dose of 4.0(pmol/g/h). | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID10942 | Bioavailability in male Sprague-Dawley rats, after the po administration at a dose of 10.0(pmol/g/h) | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID3168 | Dose to reduce neuronal firing against 5-HT cells in rats (iv) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID47961 | Dose required to completely shut off sympathetic nerve discharge in cat following intravenous administration | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID4368 | Displacement of the radioligand [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID232038 | Selectivity between D2 to that of 5-HT1A | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID10722 | Area under the curve after intravenous administration at a dose of 10 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID16501 | Cmax in minutes at a iv dose of 4.0(pmol/g/h). | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID180721 | The concentration yielding a half maximal decrease of the 5-HTP was determined in rat brain striatum. | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID178903 | In vivo for DOPA accumulation in corpus striatum against reserpine-pretreated rats. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID47962 | Dose required to reduce sympathetic nerve discharge in cat following intravenous administration | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. |
| AID178889 | In vivo for 5-HTP accumulation in corpus striatum against reserpine-pretreated rats. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID197518 | Log concentration to inhibit DOPA accumulation was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID24761 | Time taken to reach maximum concentration after administration of 4 umol/kg dose intravenously | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID624210 | Agonists at Human 5-Hydroxytryptamine receptor 5-HT1A | 1994 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 271, Issue:2
| Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. |
| AID1345615 | Human 5-HT1A receptor (5-Hydroxytryptamine receptors) | 1994 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 271, Issue:2
| Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |